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Article: Identification of the long noncoding RNA NEAT1 as a novel inflammatory regulator acting through MAPK pathway in human lupus

TitleIdentification of the long noncoding RNA NEAT1 as a novel inflammatory regulator acting through MAPK pathway in human lupus
Authors
Issue Date2016
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yjaut
Citation
Journal of Autoimmunity, 2016, v. 75, p. 96-104 How to Cite?
AbstractLong noncoding RNAs (lncRNAs) have recently been identified to be tightly linked to diverse human diseases. However, our knowledge of Systemic Lupus Erythematosus (SLE)-related lncRNAs remains limited. In the present study we investigated the contribution of the lncRNA NEAT1 to the pathogenesis of SLE. Here, we found NEAT1 expression was abnormally increased in SLE patients and predominantly expressed in human monocytes. Additionally, NEAT1 expression was induced by LPS via p38 activation. Silencing NEAT1 significantly reduced the expression of a group of chemokines and cytokines, including IL-6, CXCL10, etc., which were induced by LPS continuously and in late stages. Furthermore, it was identified the involvement of NEAT1 in TLR4-mediated inflammatory process was through affecting the activation of the late MAPK signaling pathway. Importantly, there was a positive correlation between NEAT1 and clinical disease activity in SLE patients. In conclusion, the increased NEAT1 expression may be a potential contributor to the elevated production of a number of cytokines and chemokines in SLE patients. Our findings suggest lncRNA contributes to the pathogenesis of lupus and provides potentially novel target for therapeutic intervention.
Persistent Identifierhttp://hdl.handle.net/10722/248489
ISSN
2017 Impact Factor: 7.607
2015 SCImago Journal Rankings: 1.971
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorZhang, F-
dc.contributor.authorWu, L-
dc.contributor.authorQian, J-
dc.contributor.authorQu, B-
dc.contributor.authorXia, S-
dc.contributor.authorLa, T-
dc.contributor.authorWu, Y-
dc.contributor.authorMa, J-
dc.contributor.authorZeng, J-
dc.contributor.authorGuo, Q-
dc.contributor.authorCui, Y-
dc.contributor.authorYang, W-
dc.contributor.authorHuang, J-
dc.contributor.authorZhu, W-
dc.contributor.authorYao, Y-
dc.contributor.authorShen, N-
dc.contributor.authorTang, Y-
dc.date.accessioned2017-10-18T08:44:00Z-
dc.date.available2017-10-18T08:44:00Z-
dc.date.issued2016-
dc.identifier.citationJournal of Autoimmunity, 2016, v. 75, p. 96-104-
dc.identifier.issn0896-8411-
dc.identifier.urihttp://hdl.handle.net/10722/248489-
dc.description.abstractLong noncoding RNAs (lncRNAs) have recently been identified to be tightly linked to diverse human diseases. However, our knowledge of Systemic Lupus Erythematosus (SLE)-related lncRNAs remains limited. In the present study we investigated the contribution of the lncRNA NEAT1 to the pathogenesis of SLE. Here, we found NEAT1 expression was abnormally increased in SLE patients and predominantly expressed in human monocytes. Additionally, NEAT1 expression was induced by LPS via p38 activation. Silencing NEAT1 significantly reduced the expression of a group of chemokines and cytokines, including IL-6, CXCL10, etc., which were induced by LPS continuously and in late stages. Furthermore, it was identified the involvement of NEAT1 in TLR4-mediated inflammatory process was through affecting the activation of the late MAPK signaling pathway. Importantly, there was a positive correlation between NEAT1 and clinical disease activity in SLE patients. In conclusion, the increased NEAT1 expression may be a potential contributor to the elevated production of a number of cytokines and chemokines in SLE patients. Our findings suggest lncRNA contributes to the pathogenesis of lupus and provides potentially novel target for therapeutic intervention.-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/yjaut-
dc.relation.ispartofJournal of Autoimmunity-
dc.rightsPosting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.titleIdentification of the long noncoding RNA NEAT1 as a novel inflammatory regulator acting through MAPK pathway in human lupus-
dc.typeArticle-
dc.identifier.emailYang, W: yangwl@hkucc.hku.hk-
dc.identifier.authorityYang, W=rp00524-
dc.identifier.doi10.1016/j.jaut.2016.07.012-
dc.identifier.hkuros280954-
dc.identifier.volume75-
dc.identifier.spage96-
dc.identifier.epage104-
dc.identifier.isiWOS:000389731200010-
dc.publisher.placeUnited Kingdom-

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