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Conference Paper: Qigong exercise improved quality of sleep and reduced interleukin-1 beta and interleukin-6 among persons with depressive symptoms and sleep disturbances: a randomized controlled trial

TitleQigong exercise improved quality of sleep and reduced interleukin-1 beta and interleukin-6 among persons with depressive symptoms and sleep disturbances: a randomized controlled trial
Authors
Issue Date2017
PublisherThe American Academy of Sleep Medicine. The Journal's web site is located at http://www.journalsleep.org
Citation
The 31st Annual Meeting of the Associated Professional Sleep Societies, LLC (APSS), Boston, MA, 3-7 June 2017. Sleep, 2017, v. 40 n. Suppl 1, p. A405 How to Cite?
AbstractIntroduction: Growing evidence has shown that Qigong exercise improves sleep quality and alleviates depressive symptoms. However, the mechanisms underlying the effects of Qigong exercise remain unclear. Methods: A randomized waitlist-controlled trial was conducted to assess efficacy of Qigong exercise and investigate relationship between pro-inflammatory cytokines and self-reported symptoms among depressed persons with sleep disturbance. 173 participants were screened and recruited from the community. Intervention was eight 3-hour weekly sessions of Qigong training plus 30-minute self-practice at least 3 times per week. Self-reported questionnaires, including Pittsburgh Sleep Quality Index (PSQI), Center for Epidemiologic Studies Depression Scale (CES-D) and perceived stress scale (PSS) and measurement of pro-inflammatory cytokines interleukin (IL)-1β and IL-6 were assessed at baseline (T0), immediate post-intervention (T1) and 3-month post-intervention (T2). Results: Compared with waitlist control group, independent t-tests showed that Qigong exercise significantly improved sleep quality and reduced depressive symptoms and perceived stress as measured by PSQI (-1.7 vs -0.7, p =.014), CES-D and PSS and lowered IL-6 (-0.21 vs 0.70, P = <.001) and IL-1β (-0.08 vs 0.00, P = .002) at T1. Significant association was found between PSQI change score and reduction in IL-1β level at both T1 and T2 following Qigong exercise, but not with IL-6 level; while reduction in IL-6 was significantly associated with changes in CES-D and PSS scores. Conclusion: Qigong exercise alleviated sleep disturbance and depressive symptoms, and also reduced the levels of IL-1β and IL-6. Significant associations between reduction in IL-1β and sleep improvement were found following Qigong exercise. This study sheds light on possible underlying mechanism of regulating sleep by lowering the level of IL-1β. Further studies using polysomnography for recording NREM and REM sleep are warranted to confirm our preliminary findings. Support (If Any): The Centre on Behavioral Health Research Fund of the University of Hong Kong
Persistent Identifierhttp://hdl.handle.net/10722/248282
ISSN
2015 Impact Factor: 4.793
2015 SCImago Journal Rankings: 2.606

 

DC FieldValueLanguage
dc.contributor.authorChan, JSM-
dc.contributor.authorLi, A-
dc.contributor.authorChan, CLW-
dc.contributor.authorSo, KF-
dc.contributor.authorChen, J-
dc.contributor.authorJi, X-
dc.contributor.authorYuen, LP-
dc.contributor.authorChung, KF-
dc.contributor.authorNg, SM-
dc.date.accessioned2017-10-18T08:40:45Z-
dc.date.available2017-10-18T08:40:45Z-
dc.date.issued2017-
dc.identifier.citationThe 31st Annual Meeting of the Associated Professional Sleep Societies, LLC (APSS), Boston, MA, 3-7 June 2017. Sleep, 2017, v. 40 n. Suppl 1, p. A405-
dc.identifier.issn0161-8105-
dc.identifier.urihttp://hdl.handle.net/10722/248282-
dc.description.abstractIntroduction: Growing evidence has shown that Qigong exercise improves sleep quality and alleviates depressive symptoms. However, the mechanisms underlying the effects of Qigong exercise remain unclear. Methods: A randomized waitlist-controlled trial was conducted to assess efficacy of Qigong exercise and investigate relationship between pro-inflammatory cytokines and self-reported symptoms among depressed persons with sleep disturbance. 173 participants were screened and recruited from the community. Intervention was eight 3-hour weekly sessions of Qigong training plus 30-minute self-practice at least 3 times per week. Self-reported questionnaires, including Pittsburgh Sleep Quality Index (PSQI), Center for Epidemiologic Studies Depression Scale (CES-D) and perceived stress scale (PSS) and measurement of pro-inflammatory cytokines interleukin (IL)-1β and IL-6 were assessed at baseline (T0), immediate post-intervention (T1) and 3-month post-intervention (T2). Results: Compared with waitlist control group, independent t-tests showed that Qigong exercise significantly improved sleep quality and reduced depressive symptoms and perceived stress as measured by PSQI (-1.7 vs -0.7, p =.014), CES-D and PSS and lowered IL-6 (-0.21 vs 0.70, P = <.001) and IL-1β (-0.08 vs 0.00, P = .002) at T1. Significant association was found between PSQI change score and reduction in IL-1β level at both T1 and T2 following Qigong exercise, but not with IL-6 level; while reduction in IL-6 was significantly associated with changes in CES-D and PSS scores. Conclusion: Qigong exercise alleviated sleep disturbance and depressive symptoms, and also reduced the levels of IL-1β and IL-6. Significant associations between reduction in IL-1β and sleep improvement were found following Qigong exercise. This study sheds light on possible underlying mechanism of regulating sleep by lowering the level of IL-1β. Further studies using polysomnography for recording NREM and REM sleep are warranted to confirm our preliminary findings. Support (If Any): The Centre on Behavioral Health Research Fund of the University of Hong Kong-
dc.languageeng-
dc.publisherThe American Academy of Sleep Medicine. The Journal's web site is located at http://www.journalsleep.org-
dc.relation.ispartofSleep-
dc.titleQigong exercise improved quality of sleep and reduced interleukin-1 beta and interleukin-6 among persons with depressive symptoms and sleep disturbances: a randomized controlled trial-
dc.typeConference_Paper-
dc.identifier.emailChan, JSM: chansm5@hkucc.hku.hk-
dc.identifier.emailLi, A: anglihk@hku.hk-
dc.identifier.emailChan, CLW: cecichan@hku.hk-
dc.identifier.emailSo, KF: hrmaskf@hku.hk-
dc.identifier.emailChen, J: abchen@hkucc.hku.hk-
dc.identifier.emailChung, KF: kfchung@hku.hk-
dc.identifier.emailNg, SM: ngsiuman@hku.hk-
dc.identifier.authorityChan, CLW=rp00579-
dc.identifier.authoritySo, KF=rp00329-
dc.identifier.authorityChen, J=rp01316-
dc.identifier.authorityChung, KF=rp00377-
dc.identifier.authorityNg, SM=rp00611-
dc.identifier.hkuros281435-
dc.identifier.volume40-
dc.identifier.issueSuppl 1-
dc.identifier.spageA405-
dc.identifier.epageA405-
dc.publisher.placeUnited States-

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