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Conference Paper: Anti-spike IgG exacerbates lung injury by skewing monocyte-macrophage responses during SARS-CoV infection

TitleAnti-spike IgG exacerbates lung injury by skewing monocyte-macrophage responses during SARS-CoV infection
Authors
Issue Date2017
PublisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org
Citation
Annual Meeting of the American Association of Immunologists, IMMUNOLOGY 2017, Washington, DC, 12-16 May 2017. In Journal of Immunology, 2017, v. 195 n. 1, Suppl., abstract no. 122.6 How to Cite?
AbstractDeceased SARS patients displayed severe acute lung injury (ALI) with exuberant inflammatory responses yet faster neutralizing IgG development. The mechanism underlying this discrepancy remains elusive. Here, we combine vaccination and passive immunization strategies to determine whether anti-spike (S) IgG modulates SARS-CoV-mediated lung injury in Chinese rhesus macaques. We found that macaques pre-vaccinated with MVA-S displayed more severe lung injury compared with MVA-vaccinated controls after SARS-CoV challenge. Moreover, passive immunization of purified anti-spike IgG but not control IgG resulted dose-dependently in enhanced lung infection and severer lung injury, associated with prolonged responses of pro-inflammatory alveolar MAC387+ and CD163+TGF-b- macrophages, IL-6 production and delayed wound-healing CD163+TGF-b+ macrophages response. Consistently, accumulated pro-inflammatory CD163+TGF-b- macrophages were found in lungs of deceased SARS patients. Our results demonstrated that anti-spike IgG exacerbates lung injury likely by enhancing infection and skewed alveolar monocyte-macrophage responses, which may have significant implications to CoV-mediated pathogenesis and immunotherapy.
DescriptionSession B Cells, Antibodies, and the Adaptive Immune Response to Viruses - poster abstract no. 122.6
Persistent Identifierhttp://hdl.handle.net/10722/247896
ISSN
2017 Impact Factor: 4.539
2015 SCImago Journal Rankings: 3.549

 

DC FieldValueLanguage
dc.contributor.authorLiu, L-
dc.contributor.authorWang, H-
dc.contributor.authorWei, Q-
dc.contributor.authorTang, H-
dc.contributor.authorNishiura, K-
dc.contributor.authorKwok, H-
dc.contributor.authorPeng, J-
dc.contributor.authorAlvarez, X-
dc.contributor.authorLackner, A-
dc.contributor.authorChen, Z-
dc.date.accessioned2017-10-18T08:34:25Z-
dc.date.available2017-10-18T08:34:25Z-
dc.date.issued2017-
dc.identifier.citationAnnual Meeting of the American Association of Immunologists, IMMUNOLOGY 2017, Washington, DC, 12-16 May 2017. In Journal of Immunology, 2017, v. 195 n. 1, Suppl., abstract no. 122.6-
dc.identifier.issn0022-1767-
dc.identifier.urihttp://hdl.handle.net/10722/247896-
dc.descriptionSession B Cells, Antibodies, and the Adaptive Immune Response to Viruses - poster abstract no. 122.6-
dc.description.abstractDeceased SARS patients displayed severe acute lung injury (ALI) with exuberant inflammatory responses yet faster neutralizing IgG development. The mechanism underlying this discrepancy remains elusive. Here, we combine vaccination and passive immunization strategies to determine whether anti-spike (S) IgG modulates SARS-CoV-mediated lung injury in Chinese rhesus macaques. We found that macaques pre-vaccinated with MVA-S displayed more severe lung injury compared with MVA-vaccinated controls after SARS-CoV challenge. Moreover, passive immunization of purified anti-spike IgG but not control IgG resulted dose-dependently in enhanced lung infection and severer lung injury, associated with prolonged responses of pro-inflammatory alveolar MAC387+ and CD163+TGF-b- macrophages, IL-6 production and delayed wound-healing CD163+TGF-b+ macrophages response. Consistently, accumulated pro-inflammatory CD163+TGF-b- macrophages were found in lungs of deceased SARS patients. Our results demonstrated that anti-spike IgG exacerbates lung injury likely by enhancing infection and skewed alveolar monocyte-macrophage responses, which may have significant implications to CoV-mediated pathogenesis and immunotherapy.-
dc.languageeng-
dc.publisherAmerican Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org-
dc.relation.ispartofJournal of Immunology-
dc.titleAnti-spike IgG exacerbates lung injury by skewing monocyte-macrophage responses during SARS-CoV infection-
dc.typeConference_Paper-
dc.identifier.emailLiu, L: liuli71@hkucc.hku.hk-
dc.identifier.emailChen, Z: zchenai@hku.hk-
dc.identifier.authorityLiu, L=rp00268-
dc.identifier.authorityChen, Z=rp00243-
dc.identifier.hkuros279798-
dc.identifier.volume195-
dc.identifier.issue1, Suppl.-
dc.identifier.spageabstract no. 122.6-
dc.identifier.epageabstract no. 122.6-
dc.publisher.placeUnited States-

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