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Article: Psychiatric symptoms mediate the effects of neurological soft signs on functional outcomes in patients with chronic schizophrenia: A longitudinal path-analytic study

TitlePsychiatric symptoms mediate the effects of neurological soft signs on functional outcomes in patients with chronic schizophrenia: A longitudinal path-analytic study
Authors
Issue Date2017
PublisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychres
Citation
Psychiatry Research, 2017, v. 249, p. 152-158 How to Cite?
AbstractNeurological soft signs (NSS) in motor coordination and sequencing occur in schizophrenia patients and are an intrinsic sign of the underlying neural dysfunctions. The present longitudinal study explored the relationships among NSS, psychiatric symptoms, and functional outcomes in 151 Chinese patients with chronic schizophrenia across a 6-month period. The participants completed neurological assessments at baseline (Time 1), psychiatric interviews at Time 1 and 3-month follow-up (Time 2), and self-report measures on daily functioning at 6-month follow-up (Time 3). Two possible (combined and cascading) path models were examined on predicting the functional outcomes. Direct and indirect effects of Time 1 NSS on Time 3 functional outcomes via Time 2 psychiatric symptoms were evaluated using path analysis under bootstrapping. Motor coordination and sequencing NSS did not have significant direct effects on functional outcomes. Motor coordination NSS exerted significant and negative indirect effects on functional outcomes via psychiatric symptoms. These results contribute to a better understanding of the determinants of functional outcomes by showing significant indirect pathways from motor coordination NSS to functional outcomes via psychiatric symptoms. That motor sequencing NSS did not affect functional outcomes either directly or indirectly may be explained by their trait marking features.
Persistent Identifierhttp://hdl.handle.net/10722/247570
ISSN
2017 Impact Factor: 2.223
2015 SCImago Journal Rankings: 1.235
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorFong, TCT-
dc.contributor.authorHo, RTH-
dc.contributor.authorWan, HYA-
dc.contributor.authorAu-Yeung, FSW-
dc.date.accessioned2017-10-18T08:29:18Z-
dc.date.available2017-10-18T08:29:18Z-
dc.date.issued2017-
dc.identifier.citationPsychiatry Research, 2017, v. 249, p. 152-158-
dc.identifier.issn0165-1781-
dc.identifier.urihttp://hdl.handle.net/10722/247570-
dc.description.abstractNeurological soft signs (NSS) in motor coordination and sequencing occur in schizophrenia patients and are an intrinsic sign of the underlying neural dysfunctions. The present longitudinal study explored the relationships among NSS, psychiatric symptoms, and functional outcomes in 151 Chinese patients with chronic schizophrenia across a 6-month period. The participants completed neurological assessments at baseline (Time 1), psychiatric interviews at Time 1 and 3-month follow-up (Time 2), and self-report measures on daily functioning at 6-month follow-up (Time 3). Two possible (combined and cascading) path models were examined on predicting the functional outcomes. Direct and indirect effects of Time 1 NSS on Time 3 functional outcomes via Time 2 psychiatric symptoms were evaluated using path analysis under bootstrapping. Motor coordination and sequencing NSS did not have significant direct effects on functional outcomes. Motor coordination NSS exerted significant and negative indirect effects on functional outcomes via psychiatric symptoms. These results contribute to a better understanding of the determinants of functional outcomes by showing significant indirect pathways from motor coordination NSS to functional outcomes via psychiatric symptoms. That motor sequencing NSS did not affect functional outcomes either directly or indirectly may be explained by their trait marking features.-
dc.languageeng-
dc.publisherElsevier Ireland Ltd. The Journal's web site is located at http://www.elsevier.com/locate/psychres-
dc.relation.ispartofPsychiatry Research-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titlePsychiatric symptoms mediate the effects of neurological soft signs on functional outcomes in patients with chronic schizophrenia: A longitudinal path-analytic study-
dc.typeArticle-
dc.identifier.emailFong, TCT: ttaatt@hku.hk-
dc.identifier.emailHo, RTH: tinho@hku.hk-
dc.identifier.emailWan, HYA: awan@hku.hk-
dc.identifier.authorityHo, RTH=rp00497-
dc.description.naturepostprint-
dc.identifier.doi10.1016/j.psychres.2017.01.023-
dc.identifier.hkuros280126-
dc.identifier.volume249-
dc.identifier.spage152-
dc.identifier.epage158-
dc.identifier.isiWOS:000397377600023-
dc.publisher.placeIreland-

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