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Article: Fluorescent Probes for HOCl Imaging

TitleFluorescent Probes for HOCl Imaging
Authors
KeywordsFluorescent probes
Fluorophores
Hypochlorous acid
Imaging agents
Reactive oxygen species
Issue Date2017
PublisherWiley-VCH Verlag. The Journal's web site is located at http://www.wiley-vch.de/en/shop/journals/388
Citation
Israel Journal of Chemistry, 2017, v. 57 n. 3-4, p. 251-258 How to Cite?
AbstractSmall‐molecule fluorescent probes for hypochlorous acid (HOCl), one of the poorly understood reactive oxygen species (ROS), help to unveil HOCl functions in health and disease. Numerous small‐molecule HOCl fluorescent probes have been developed in the past decade. Nevertheless, only a portion of them demonstrated their practical applications in biomedical research because of common problems in selectivity, sensitivity, chemostability, and photostability, etc. The problems could be addressed by a combination of rational probe design and careful selection of fluorophore templates. In this review, we describe several classes of representative HOCl fluorescent probes based on their fluorophore templates, and we discuss their design strategies, photophysical properties, and biological applications. A comprehension of their strengths, weaknesses, and common uses will facilitate the development of ideal HOCl assays and the discovery of novel biological processes.
Persistent Identifierhttp://hdl.handle.net/10722/247277
ISSN
2023 Impact Factor: 2.3
2023 SCImago Journal Rankings: 0.987
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHu, JJ-
dc.contributor.authorYe, S-
dc.contributor.authorYang, D-
dc.date.accessioned2017-10-18T08:24:56Z-
dc.date.available2017-10-18T08:24:56Z-
dc.date.issued2017-
dc.identifier.citationIsrael Journal of Chemistry, 2017, v. 57 n. 3-4, p. 251-258-
dc.identifier.issn0021-2148-
dc.identifier.urihttp://hdl.handle.net/10722/247277-
dc.description.abstractSmall‐molecule fluorescent probes for hypochlorous acid (HOCl), one of the poorly understood reactive oxygen species (ROS), help to unveil HOCl functions in health and disease. Numerous small‐molecule HOCl fluorescent probes have been developed in the past decade. Nevertheless, only a portion of them demonstrated their practical applications in biomedical research because of common problems in selectivity, sensitivity, chemostability, and photostability, etc. The problems could be addressed by a combination of rational probe design and careful selection of fluorophore templates. In this review, we describe several classes of representative HOCl fluorescent probes based on their fluorophore templates, and we discuss their design strategies, photophysical properties, and biological applications. A comprehension of their strengths, weaknesses, and common uses will facilitate the development of ideal HOCl assays and the discovery of novel biological processes.-
dc.languageeng-
dc.publisherWiley-VCH Verlag. The Journal's web site is located at http://www.wiley-vch.de/en/shop/journals/388-
dc.relation.ispartofIsrael Journal of Chemistry-
dc.subjectFluorescent probes-
dc.subjectFluorophores-
dc.subjectHypochlorous acid-
dc.subjectImaging agents-
dc.subjectReactive oxygen species-
dc.titleFluorescent Probes for HOCl Imaging-
dc.typeArticle-
dc.identifier.emailYe, S: yesen@hku.hk-
dc.identifier.emailYang, D: yangdan@hku.hk-
dc.identifier.authorityYe, S=rp02805-
dc.identifier.authorityYang, D=rp00825-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ijch.201600113-
dc.identifier.scopuseid_2-s2.0-85010749142-
dc.identifier.hkuros281525-
dc.identifier.volume57-
dc.identifier.issue3-4-
dc.identifier.spage251-
dc.identifier.epage258-
dc.identifier.isiWOS:000398822700009-
dc.publisher.placeGermany-

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