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Conference Paper: Differential expression of stromal cell-related genes between primary nasopharyngeal carcinoma and distant metastasis

TitleDifferential expression of stromal cell-related genes between primary nasopharyngeal carcinoma and distant metastasis
Authors
Issue Date2015
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Proceedings of the 106th Annual Meeting of the American Association for Cancer Research (AACR 2015), Philadelphia, PA., 18-22 April 2015. In Cancer Research, 2015, v. 75 n. 15, Suppl., p. abstract no. 2177 How to Cite?
AbstractStromal cells in the tumor microenviroment play an important role in development and progression of nasopharyngeal carcinoma (NPC). Aim of this study is to identify the stromal cell related genes which may promote distant metastasis in NPC. Materials and methods: Differently expressed genes were accessed by comparing nasopharyngeal carcinoma and distant metastasis by microarray. Then stromal cells related genes were analyzed by using statistics tools. Five selected genes were validated in 112 nasopharyngeal carcinoma specimens. Results: We have identified 3360 genes up-regulated (P < .05)and 2327 genes down-regulated(P < .05) in distant metastasis versus primary nasopharyngeal carcinoma, among the differently expressed genes,111 stromal cells related genes were picked up according to previous researches for cluster analysis and pathway analysis. Upon validating 5 selected genes (BIRC3,FRAS1,NPNT,POSTN,PCSK6) in 112 additional NPC cases, the authors found that expression of POSTN was negative correlated significantly with lymph node involvement (p = 0.006)and clinical stage(p = 0.035) at the moment of diagnosis and FRAS1 was negative correlated with disease-free survival (p = 0.002) and distant metastasis survival (p = 0.02).Conclusion: Increasing knowledge of metastasis promotion of stromal cells related genes may provide feasible explanations underlying NPC progression and metastasis along with the development of biomarkers for screening high-risk populations.
Persistent Identifierhttp://hdl.handle.net/10722/246162
ISSN
2017 Impact Factor: 9.13
2015 SCImago Journal Rankings: 5.372
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKe, L-
dc.contributor.authorChen, J-
dc.contributor.authorWang, L-
dc.contributor.authorYu, Y-
dc.contributor.authorYe, Y-
dc.contributor.authorXia, W-
dc.contributor.authorLv, X-
dc.contributor.authorYang, J-
dc.contributor.authorGuo, X-
dc.contributor.authorXiang, Y-
dc.contributor.authorGuan, X-
dc.date.accessioned2017-09-18T02:23:31Z-
dc.date.available2017-09-18T02:23:31Z-
dc.date.issued2015-
dc.identifier.citationProceedings of the 106th Annual Meeting of the American Association for Cancer Research (AACR 2015), Philadelphia, PA., 18-22 April 2015. In Cancer Research, 2015, v. 75 n. 15, Suppl., p. abstract no. 2177-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/246162-
dc.description.abstractStromal cells in the tumor microenviroment play an important role in development and progression of nasopharyngeal carcinoma (NPC). Aim of this study is to identify the stromal cell related genes which may promote distant metastasis in NPC. Materials and methods: Differently expressed genes were accessed by comparing nasopharyngeal carcinoma and distant metastasis by microarray. Then stromal cells related genes were analyzed by using statistics tools. Five selected genes were validated in 112 nasopharyngeal carcinoma specimens. Results: We have identified 3360 genes up-regulated (P < .05)and 2327 genes down-regulated(P < .05) in distant metastasis versus primary nasopharyngeal carcinoma, among the differently expressed genes,111 stromal cells related genes were picked up according to previous researches for cluster analysis and pathway analysis. Upon validating 5 selected genes (BIRC3,FRAS1,NPNT,POSTN,PCSK6) in 112 additional NPC cases, the authors found that expression of POSTN was negative correlated significantly with lymph node involvement (p = 0.006)and clinical stage(p = 0.035) at the moment of diagnosis and FRAS1 was negative correlated with disease-free survival (p = 0.002) and distant metastasis survival (p = 0.02).Conclusion: Increasing knowledge of metastasis promotion of stromal cells related genes may provide feasible explanations underlying NPC progression and metastasis along with the development of biomarkers for screening high-risk populations.-
dc.languageeng-
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/-
dc.relation.ispartofCancer Research-
dc.titleDifferential expression of stromal cell-related genes between primary nasopharyngeal carcinoma and distant metastasis-
dc.typeConference_Paper-
dc.identifier.emailGuan, X: xyguan@hkucc.hku.hk-
dc.identifier.authorityGuan, X=rp00454-
dc.identifier.doi10.1158/1538-7445.AM2015-2177-
dc.identifier.hkuros276967-
dc.identifier.volume75-
dc.identifier.issue15, Suppl.-
dc.identifier.spageabstract no. 2177-
dc.identifier.epageabstract no. 2177-
dc.identifier.isiWOS:000371578504282-
dc.publisher.placeUnited States-

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