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Conference Paper: Identification and characterization of ITGA7 as cancer stem cell marker in esophageal squamous cell carcinoma (ESCC)

TitleIdentification and characterization of ITGA7 as cancer stem cell marker in esophageal squamous cell carcinoma (ESCC)
Authors
Issue Date2014
PublisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/
Citation
Proceedings of 105th American Association for Cancer Research (AACR) Annual Meeting 2014, San Diego, CA, USA, 5-9 April 2014. In Cancer Research, 2014, v. 74 n. 19, Suppl., p. Abstract no. 3872 How to Cite?
AbstractCancer stem cells (CSCs) are widely accepted as a specific subpopulation of cells responsible for cancer initiation and progression. CSCs have yet to be identified in ESCC that have an increasing incidence in developed countries. Our recent study in esophageal squamous cell carcinoma (ESCC) has led to the identification of ITGA7 as a functional CSCs marker. ITGA7+ cell population is endowed with stem cell-like properties and high tumorigenic and metastatic potential. ITGA7+ CSCs isolated from ESCC cell lines possessed higher self-renewal activity and were sufficient for tumor initiation, differentiation, and metastasis compared to ITGA7- ESCC cells. Functional studies using lentiviral-based overexpression and suppression systems demonstrated that ITGA7 can promote tumor initiation and metastasis through a deregulated FAK-Raf-MEK1/2-ERK signaling pathway and epithelial-mesenchymal transition. Further characterization of ITGA7+ population may provide a prognostic biomarker for ESCC outcome prediction and a potential therapeutic target.
Persistent Identifierhttp://hdl.handle.net/10722/246159
ISSN
2015 Impact Factor: 8.556
2015 SCImago Journal Rankings: 5.372

 

DC FieldValueLanguage
dc.contributor.authorMing, X-
dc.contributor.authorFu, L-
dc.contributor.authorZhang, L-
dc.contributor.authorGuan, X-
dc.date.accessioned2017-09-18T02:23:28Z-
dc.date.available2017-09-18T02:23:28Z-
dc.date.issued2014-
dc.identifier.citationProceedings of 105th American Association for Cancer Research (AACR) Annual Meeting 2014, San Diego, CA, USA, 5-9 April 2014. In Cancer Research, 2014, v. 74 n. 19, Suppl., p. Abstract no. 3872-
dc.identifier.issn0008-5472-
dc.identifier.urihttp://hdl.handle.net/10722/246159-
dc.description.abstractCancer stem cells (CSCs) are widely accepted as a specific subpopulation of cells responsible for cancer initiation and progression. CSCs have yet to be identified in ESCC that have an increasing incidence in developed countries. Our recent study in esophageal squamous cell carcinoma (ESCC) has led to the identification of ITGA7 as a functional CSCs marker. ITGA7+ cell population is endowed with stem cell-like properties and high tumorigenic and metastatic potential. ITGA7+ CSCs isolated from ESCC cell lines possessed higher self-renewal activity and were sufficient for tumor initiation, differentiation, and metastasis compared to ITGA7- ESCC cells. Functional studies using lentiviral-based overexpression and suppression systems demonstrated that ITGA7 can promote tumor initiation and metastasis through a deregulated FAK-Raf-MEK1/2-ERK signaling pathway and epithelial-mesenchymal transition. Further characterization of ITGA7+ population may provide a prognostic biomarker for ESCC outcome prediction and a potential therapeutic target.-
dc.languageeng-
dc.publisherAmerican Association for Cancer Research. The Journal's web site is located at http://cancerres.aacrjournals.org/-
dc.relation.ispartofCancer Research-
dc.titleIdentification and characterization of ITGA7 as cancer stem cell marker in esophageal squamous cell carcinoma (ESCC)-
dc.typeConference_Paper-
dc.identifier.emailGuan, X: xyguan@hkucc.hku.hk-
dc.identifier.authorityFu, L=rp01435-
dc.identifier.authorityGuan, X=rp00454-
dc.identifier.doi10.1158/1538-7445.AM2014-3872-
dc.identifier.hkuros276959-
dc.identifier.volume74-
dc.identifier.issue19, Suppl.-
dc.identifier.spageAbstract no. 3872-
dc.identifier.epageAbstract no. 3872-
dc.publisher.placeUnited States-

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