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Article: Aflibercept-induced Nephrotic Syndrome
Title | Aflibercept-induced Nephrotic Syndrome 阿普西柏誘發的腎病綜合症 |
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Authors | |
Keywords | Aflibercept Colorectal neoplasms Nephrotic syndrome Proteinuria |
Issue Date | 2017 |
Publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkjr.org |
Citation | Hong Kong Journal of Radiology, 2017, v. 20, p. 146-148 How to Cite? |
Abstract | Aflibercept is a high-affinity ligand trap for vascular endothelial growth factor (VEGF) and is used as secondline therapy against metastatic colorectal cancer. It has a similar but potentially less favourable toxicity profile compared with other anti-angiogenic agents. We report a Chinese woman with metastatic colorectal cancer who developed nephrotic syndrome after a single dose of aflibercept (4 mg/kg) with FOLFIRI (leucovorin, fluorouracil, and irinotecan). On days 11 and 18, 24-hour urine collection showed urine protein of 6.07 and 8.72 g/day, respectively. Renal biopsy revealed chronic interstitial nephritis due to underlying obstructive uropathy. The nephrotic syndrome resolved after stopping aflibercept. This illustrates the reversible nature of aflibercept-induced proteinuria, especially when detected and treated early. It is important to monitor the urine protein level in patients prescribed aflibercept, even in those who tolerate other anti-VEGF therapies without significant proteinuria. |
Persistent Identifier | http://hdl.handle.net/10722/244874 |
ISSN | 2023 Impact Factor: 0.2 2023 SCImago Journal Rankings: 0.127 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | So, TH | - |
dc.contributor.author | Lee, VHF | - |
dc.contributor.author | Lam, KO | - |
dc.date.accessioned | 2017-09-18T02:00:36Z | - |
dc.date.available | 2017-09-18T02:00:36Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | Hong Kong Journal of Radiology, 2017, v. 20, p. 146-148 | - |
dc.identifier.issn | 2223-6619 | - |
dc.identifier.uri | http://hdl.handle.net/10722/244874 | - |
dc.description.abstract | Aflibercept is a high-affinity ligand trap for vascular endothelial growth factor (VEGF) and is used as secondline therapy against metastatic colorectal cancer. It has a similar but potentially less favourable toxicity profile compared with other anti-angiogenic agents. We report a Chinese woman with metastatic colorectal cancer who developed nephrotic syndrome after a single dose of aflibercept (4 mg/kg) with FOLFIRI (leucovorin, fluorouracil, and irinotecan). On days 11 and 18, 24-hour urine collection showed urine protein of 6.07 and 8.72 g/day, respectively. Renal biopsy revealed chronic interstitial nephritis due to underlying obstructive uropathy. The nephrotic syndrome resolved after stopping aflibercept. This illustrates the reversible nature of aflibercept-induced proteinuria, especially when detected and treated early. It is important to monitor the urine protein level in patients prescribed aflibercept, even in those who tolerate other anti-VEGF therapies without significant proteinuria. | - |
dc.language | eng | - |
dc.publisher | Hong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkjr.org | - |
dc.relation.ispartof | Hong Kong Journal of Radiology | - |
dc.rights | Hong Kong Journal of Radiology. Copyright © Hong Kong Academy of Medicine Press. | - |
dc.subject | Aflibercept | - |
dc.subject | Colorectal neoplasms | - |
dc.subject | Nephrotic syndrome | - |
dc.subject | Proteinuria | - |
dc.title | Aflibercept-induced Nephrotic Syndrome | - |
dc.title | 阿普西柏誘發的腎病綜合症 | - |
dc.type | Article | - |
dc.identifier.email | So, TH: sth495@hku.hk | - |
dc.identifier.email | Lee, VHF: vhflee@hku.hk | - |
dc.identifier.email | Lam, KO: lamkaon@hku.hk | - |
dc.identifier.authority | So, TH=rp01981 | - |
dc.identifier.authority | Lee, VHF=rp00264 | - |
dc.identifier.authority | Lam, KO=rp01501 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.12809/hkjr1716809 | - |
dc.identifier.scopus | eid_2-s2.0-85026227418 | - |
dc.identifier.hkuros | 276376 | - |
dc.identifier.volume | 20 | - |
dc.identifier.spage | 146 | - |
dc.identifier.epage | 148 | - |
dc.identifier.isi | WOS:000417028700012 | - |
dc.publisher.place | Hong Kong | - |
dc.identifier.issnl | 2223-6619 | - |