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Article: A randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children

TitleA randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children
Authors
KeywordsChloral hydrate
Dexmedetomidine
Intranasal
Paediatric
Sedation
Tomography
Issue Date2017
PublisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2044
Citation
Anaesthesia, 2017, v. 72 n. 10, p. 1191-1195 How to Cite?
AbstractChloral hydrate is commonly used to sedate children for painless procedures. Children may recover more quickly after sedation with dexmedetomidine, which has a shorter half‐life. We randomly allocated 196 children to chloral hydrate syrup 50 mg.kg−1 and intranasal saline spray, or placebo syrup and intranasal dexmedetomidine spray 3 μg.kg−1, 30 min before computerised tomography studies. More children resisted or cried after drinking chloral hydrate syrup than placebo syrup, 72 of 107 (67%) vs. 42 of 87 (48%), p = 0.009, but there was no difference after intranasal saline vs. dexmedetomidine, 49 of 107 (46%) vs. 40 of 87 (46%), p = 0.98. Sedation was satisfactory in 81 of 107 (76%) children after chloral hydrate and 64 of 87 (74%) children after dexmedetomidine, p = 0.74. Of the 173 children followed up for at least 4 h after discharge, 38 of 97 (39%) had recovered normal function after chloral hydrate and 32 of 76 (42%) after dexmedetomidine, p = 0.76. Six children vomited after chloral hydrate syrup and placebo spray vs. none after placebo syrup and dexmedetomidine spray, p = 0.03.
Persistent Identifierhttp://hdl.handle.net/10722/244805
ISSN
2019 Impact Factor: 5.739
2015 SCImago Journal Rankings: 1.404
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorYuen, VM-
dc.contributor.authorLi, BL-
dc.contributor.authorCheuk, DK-
dc.contributor.authorLeung, MKM-
dc.contributor.authorHui, TWC-
dc.contributor.authorWong, IC-
dc.contributor.authorLam, WW-
dc.contributor.authorChoi, SW-
dc.contributor.authorIrwin, MG-
dc.date.accessioned2017-09-18T01:59:22Z-
dc.date.available2017-09-18T01:59:22Z-
dc.date.issued2017-
dc.identifier.citationAnaesthesia, 2017, v. 72 n. 10, p. 1191-1195-
dc.identifier.issn0003-2409-
dc.identifier.urihttp://hdl.handle.net/10722/244805-
dc.description.abstractChloral hydrate is commonly used to sedate children for painless procedures. Children may recover more quickly after sedation with dexmedetomidine, which has a shorter half‐life. We randomly allocated 196 children to chloral hydrate syrup 50 mg.kg−1 and intranasal saline spray, or placebo syrup and intranasal dexmedetomidine spray 3 μg.kg−1, 30 min before computerised tomography studies. More children resisted or cried after drinking chloral hydrate syrup than placebo syrup, 72 of 107 (67%) vs. 42 of 87 (48%), p = 0.009, but there was no difference after intranasal saline vs. dexmedetomidine, 49 of 107 (46%) vs. 40 of 87 (46%), p = 0.98. Sedation was satisfactory in 81 of 107 (76%) children after chloral hydrate and 64 of 87 (74%) children after dexmedetomidine, p = 0.74. Of the 173 children followed up for at least 4 h after discharge, 38 of 97 (39%) had recovered normal function after chloral hydrate and 32 of 76 (42%) after dexmedetomidine, p = 0.76. Six children vomited after chloral hydrate syrup and placebo spray vs. none after placebo syrup and dexmedetomidine spray, p = 0.03.-
dc.languageeng-
dc.publisherWiley-Blackwell Publishing Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1365-2044-
dc.relation.ispartofAnaesthesia-
dc.subjectChloral hydrate-
dc.subjectDexmedetomidine-
dc.subjectIntranasal-
dc.subjectPaediatric-
dc.subjectSedation-
dc.subjectTomography-
dc.titleA randomised controlled trial of oral chloral hydrate vs. intranasal dexmedetomidine before computerised tomography in children-
dc.typeArticle-
dc.identifier.emailYuen, VM: vtang131@hku.hk-
dc.identifier.emailLeung, MKM: meil@hku.hk-
dc.identifier.emailHui, TWC: huitwc@hkucc.hku.hk-
dc.identifier.emailChoi, SW: htswchoi@hku.hk-
dc.identifier.emailIrwin, MG: mgirwin@hku.hk-
dc.identifier.authorityChoi, SW=rp02552-
dc.identifier.authorityIrwin, MG=rp00390-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1111/anae.13981-
dc.identifier.pmid28741653-
dc.identifier.scopuseid_2-s2.0-85026347799-
dc.identifier.hkuros278255-
dc.identifier.volume72-
dc.identifier.issue10-
dc.identifier.spage1191-
dc.identifier.epage1195-
dc.identifier.isiWOS:000410105000006-
dc.publisher.placeUnited Kingdom-

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