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Article: The DCDC2 deletion is not a risk factor for dyslexia

TitleThe DCDC2 deletion is not a risk factor for dyslexia
Authors
Issue Date2017
PublisherNature Publishing Group: Open Access Journals - Option B. The Journal's web site is located at http://www.nature.com/tp/index.html
Citation
Translational Psychiatry, 2017, v. 7, p. e1182 How to Cite?
AbstractDyslexia is a specific impairment in learning to read and has strong heritability. An intronic deletion within the DCDC2 gene, with ~8% frequency in European populations, is increasingly used as a marker for dyslexia in neuroimaging and behavioral studies. At a mechanistic level, this deletion has been proposed to influence sensory processing capacity, and in particular sensitivity to visual coherent motion. Our re-assessment of the literature, however, did not reveal strong support for a role of this specific deletion in dyslexia. We also analyzed data from five distinct cohorts, enriched for individuals with dyslexia, and did not identify any signal indicative of associations for the DCDC2 deletion with reading-related measures, including in a combined sample analysis (N=526). We believe we conducted the first replication analysis for a proposed deletion effect on visual motion perception and found no association (N=445 siblings). We also report that the DCDC2 deletion has a frequency of 37.6% in a cohort representative of the general population recruited in Hong Kong (N=220). This figure, together with a lack of association between the deletion and reading abilities in this cohort, indicates the low likelihood of a direct deletion effect on reading skills. Therefore, on the basis of multiple strands of evidence, we conclude that the DCDC2 deletion is not a strong risk factor for dyslexia. Our analyses and literature re-evaluation are important for interpreting current developments within multidisciplinary studies of dyslexia and, more generally, contribute to current discussions about the importance of reproducibility in science.
Persistent Identifierhttp://hdl.handle.net/10722/244726
ISSN
2017 Impact Factor: 4.691
2015 SCImago Journal Rankings: 3.057
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorScerri, TS-
dc.contributor.authorMacpherson, E-
dc.contributor.authorMartinelli, A-
dc.contributor.authorWa, WC-
dc.contributor.authorMonaco, AP-
dc.contributor.authorStein, J-
dc.contributor.authorZheng, M-
dc.contributor.authorHo, CSH-
dc.contributor.authorMcBride, C-
dc.contributor.authorSnowling, M-
dc.contributor.authorHulme, C-
dc.contributor.authorHayiou-Thomas, ME-
dc.contributor.authorWaye, MMY-
dc.contributor.authorTalcott, JB-
dc.contributor.authorParacchini, S-
dc.date.accessioned2017-09-18T01:57:54Z-
dc.date.available2017-09-18T01:57:54Z-
dc.date.issued2017-
dc.identifier.citationTranslational Psychiatry, 2017, v. 7, p. e1182-
dc.identifier.issn2158-3188-
dc.identifier.urihttp://hdl.handle.net/10722/244726-
dc.description.abstractDyslexia is a specific impairment in learning to read and has strong heritability. An intronic deletion within the DCDC2 gene, with ~8% frequency in European populations, is increasingly used as a marker for dyslexia in neuroimaging and behavioral studies. At a mechanistic level, this deletion has been proposed to influence sensory processing capacity, and in particular sensitivity to visual coherent motion. Our re-assessment of the literature, however, did not reveal strong support for a role of this specific deletion in dyslexia. We also analyzed data from five distinct cohorts, enriched for individuals with dyslexia, and did not identify any signal indicative of associations for the DCDC2 deletion with reading-related measures, including in a combined sample analysis (N=526). We believe we conducted the first replication analysis for a proposed deletion effect on visual motion perception and found no association (N=445 siblings). We also report that the DCDC2 deletion has a frequency of 37.6% in a cohort representative of the general population recruited in Hong Kong (N=220). This figure, together with a lack of association between the deletion and reading abilities in this cohort, indicates the low likelihood of a direct deletion effect on reading skills. Therefore, on the basis of multiple strands of evidence, we conclude that the DCDC2 deletion is not a strong risk factor for dyslexia. Our analyses and literature re-evaluation are important for interpreting current developments within multidisciplinary studies of dyslexia and, more generally, contribute to current discussions about the importance of reproducibility in science.-
dc.languageeng-
dc.publisherNature Publishing Group: Open Access Journals - Option B. The Journal's web site is located at http://www.nature.com/tp/index.html-
dc.relation.ispartofTranslational Psychiatry-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleThe DCDC2 deletion is not a risk factor for dyslexia-
dc.typeArticle-
dc.identifier.emailZheng, M: zhengmo@hku.hk-
dc.identifier.emailHo, CSH: shhoc@hkucc.hku.hk-
dc.identifier.authorityHo, CSH=rp00631-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1038/tp.2017.151-
dc.identifier.pmcidPMC5538127-
dc.identifier.hkuros276272-
dc.identifier.volume7-
dc.identifier.spagee1182-
dc.identifier.epagee1182-
dc.identifier.isiWOS:000406715200008-
dc.publisher.placeUnited Kingdom-

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