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Article: The prognostic value of Ki-67 expression in penile squamous cell carcinoma

TitleThe prognostic value of Ki-67 expression in penile squamous cell carcinoma
Authors
Issue Date2012
Citation
Journal of Clinical Pathology, 2012, v. 65, n. 6, p. 534-537 How to Cite?
AbstractAims: To determine whether Ki-67 immunoexpression in penile squamous cell carcinoma (PSCC) has a prognostic value and correlates with lymph node metastasis, human papillomavirus (HPV) infection and patient survival. Methods: 148 formalin-fixed paraffin-embedded PSCC samples were tissue-microarrayed, including 97 usual-type SCCs, 17 basaloid, 15 pure verrucous carcinomas, 2 warty and 17 mixed-type tumours. All samples were immunostained for Ki-67 protein. HPV DNA was detected with INNO-LiPA assay. Follow-up data were available for 134 patients. Results: Ki-67 was strongly expressed in 57/148 (38.5%) of PSCCs. Different cancer subtypes showed significant difference in Ki-67 expression (p < 0.0001) with highest positivity in basaloid, 16/17 (94%), followed by usual type, 38/97 (39%) and lack of Ki-67 positive cases within verrucous tumours, 0/15. Ki-67 positively correlated with high-risk HPV (p < 0.0001) and showed good specificity (84%) but low sensitivity (61%) for high-risk HPV detection. Ki-67 protein strongly positively correlated with tumour grade (p < 0.0001) but not with stage (p=0.2193), or lymph node status (p=0.7366). Ki-67 showed no prognostic value for cancer-specific survival (HR=1.00, 95%, CI 0.99 to 1.02, p=0.54) or overall survival (HR=1.00, 95%, CI 0.99 to 1.02, p=0.45). High tumour stage, lymph node metastasis, high tumour grade and age at diagnosis were all independent prognostic factors for cancer-specific survival and overall survival. Conclusions: Ki-67 is only a moderate surrogate marker for HPV infection in PSCC. It does not show prognostic value for cancer-specific survival and overall survival in PSCC.
Persistent Identifierhttp://hdl.handle.net/10722/244131
ISSN
2015 Impact Factor: 2.912
2015 SCImago Journal Rankings: 1.260

 

DC FieldValueLanguage
dc.contributor.authorStankiewicz, Elzbieta-
dc.contributor.authorNg, Mansum-
dc.contributor.authorCuzick, Jack-
dc.contributor.authorMesher, David-
dc.contributor.authorWatkin, Nick-
dc.contributor.authorLam, Wayne-
dc.contributor.authorCorbishley, Cathy-
dc.contributor.authorBerney, Daniel M.-
dc.date.accessioned2017-08-31T08:56:08Z-
dc.date.available2017-08-31T08:56:08Z-
dc.date.issued2012-
dc.identifier.citationJournal of Clinical Pathology, 2012, v. 65, n. 6, p. 534-537-
dc.identifier.issn0021-9746-
dc.identifier.urihttp://hdl.handle.net/10722/244131-
dc.description.abstractAims: To determine whether Ki-67 immunoexpression in penile squamous cell carcinoma (PSCC) has a prognostic value and correlates with lymph node metastasis, human papillomavirus (HPV) infection and patient survival. Methods: 148 formalin-fixed paraffin-embedded PSCC samples were tissue-microarrayed, including 97 usual-type SCCs, 17 basaloid, 15 pure verrucous carcinomas, 2 warty and 17 mixed-type tumours. All samples were immunostained for Ki-67 protein. HPV DNA was detected with INNO-LiPA assay. Follow-up data were available for 134 patients. Results: Ki-67 was strongly expressed in 57/148 (38.5%) of PSCCs. Different cancer subtypes showed significant difference in Ki-67 expression (p < 0.0001) with highest positivity in basaloid, 16/17 (94%), followed by usual type, 38/97 (39%) and lack of Ki-67 positive cases within verrucous tumours, 0/15. Ki-67 positively correlated with high-risk HPV (p < 0.0001) and showed good specificity (84%) but low sensitivity (61%) for high-risk HPV detection. Ki-67 protein strongly positively correlated with tumour grade (p < 0.0001) but not with stage (p=0.2193), or lymph node status (p=0.7366). Ki-67 showed no prognostic value for cancer-specific survival (HR=1.00, 95%, CI 0.99 to 1.02, p=0.54) or overall survival (HR=1.00, 95%, CI 0.99 to 1.02, p=0.45). High tumour stage, lymph node metastasis, high tumour grade and age at diagnosis were all independent prognostic factors for cancer-specific survival and overall survival. Conclusions: Ki-67 is only a moderate surrogate marker for HPV infection in PSCC. It does not show prognostic value for cancer-specific survival and overall survival in PSCC.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Pathology-
dc.titleThe prognostic value of Ki-67 expression in penile squamous cell carcinoma-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1136/jclinpath-2011-200638-
dc.identifier.pmid22447920-
dc.identifier.scopuseid_2-s2.0-84861826960-
dc.identifier.volume65-
dc.identifier.issue6-
dc.identifier.spage534-
dc.identifier.epage537-
dc.identifier.eissn1472-4146-

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