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- Publisher Website: 10.1136/jclinpath-2011-200638
- Scopus: eid_2-s2.0-84861826960
- PMID: 22447920
- WOS: WOS:000304609900010
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Article: The prognostic value of Ki-67 expression in penile squamous cell carcinoma
Title | The prognostic value of Ki-67 expression in penile squamous cell carcinoma |
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Authors | |
Issue Date | 2012 |
Citation | Journal of Clinical Pathology, 2012, v. 65, n. 6, p. 534-537 How to Cite? |
Abstract | Aims: To determine whether Ki-67 immunoexpression in penile squamous cell carcinoma (PSCC) has a prognostic value and correlates with lymph node metastasis, human papillomavirus (HPV) infection and patient survival. Methods: 148 formalin-fixed paraffin-embedded PSCC samples were tissue-microarrayed, including 97 usual-type SCCs, 17 basaloid, 15 pure verrucous carcinomas, 2 warty and 17 mixed-type tumours. All samples were immunostained for Ki-67 protein. HPV DNA was detected with INNO-LiPA assay. Follow-up data were available for 134 patients. Results: Ki-67 was strongly expressed in 57/148 (38.5%) of PSCCs. Different cancer subtypes showed significant difference in Ki-67 expression (p < 0.0001) with highest positivity in basaloid, 16/17 (94%), followed by usual type, 38/97 (39%) and lack of Ki-67 positive cases within verrucous tumours, 0/15. Ki-67 positively correlated with high-risk HPV (p < 0.0001) and showed good specificity (84%) but low sensitivity (61%) for high-risk HPV detection. Ki-67 protein strongly positively correlated with tumour grade (p < 0.0001) but not with stage (p=0.2193), or lymph node status (p=0.7366). Ki-67 showed no prognostic value for cancer-specific survival (HR=1.00, 95%, CI 0.99 to 1.02, p=0.54) or overall survival (HR=1.00, 95%, CI 0.99 to 1.02, p=0.45). High tumour stage, lymph node metastasis, high tumour grade and age at diagnosis were all independent prognostic factors for cancer-specific survival and overall survival. Conclusions: Ki-67 is only a moderate surrogate marker for HPV infection in PSCC. It does not show prognostic value for cancer-specific survival and overall survival in PSCC. |
Persistent Identifier | http://hdl.handle.net/10722/244131 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.934 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Stankiewicz, Elzbieta | - |
dc.contributor.author | Ng, Mansum | - |
dc.contributor.author | Cuzick, Jack | - |
dc.contributor.author | Mesher, David | - |
dc.contributor.author | Watkin, Nick | - |
dc.contributor.author | Lam, Wayne | - |
dc.contributor.author | Corbishley, Cathy | - |
dc.contributor.author | Berney, Daniel M. | - |
dc.date.accessioned | 2017-08-31T08:56:08Z | - |
dc.date.available | 2017-08-31T08:56:08Z | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Journal of Clinical Pathology, 2012, v. 65, n. 6, p. 534-537 | - |
dc.identifier.issn | 0021-9746 | - |
dc.identifier.uri | http://hdl.handle.net/10722/244131 | - |
dc.description.abstract | Aims: To determine whether Ki-67 immunoexpression in penile squamous cell carcinoma (PSCC) has a prognostic value and correlates with lymph node metastasis, human papillomavirus (HPV) infection and patient survival. Methods: 148 formalin-fixed paraffin-embedded PSCC samples were tissue-microarrayed, including 97 usual-type SCCs, 17 basaloid, 15 pure verrucous carcinomas, 2 warty and 17 mixed-type tumours. All samples were immunostained for Ki-67 protein. HPV DNA was detected with INNO-LiPA assay. Follow-up data were available for 134 patients. Results: Ki-67 was strongly expressed in 57/148 (38.5%) of PSCCs. Different cancer subtypes showed significant difference in Ki-67 expression (p < 0.0001) with highest positivity in basaloid, 16/17 (94%), followed by usual type, 38/97 (39%) and lack of Ki-67 positive cases within verrucous tumours, 0/15. Ki-67 positively correlated with high-risk HPV (p < 0.0001) and showed good specificity (84%) but low sensitivity (61%) for high-risk HPV detection. Ki-67 protein strongly positively correlated with tumour grade (p < 0.0001) but not with stage (p=0.2193), or lymph node status (p=0.7366). Ki-67 showed no prognostic value for cancer-specific survival (HR=1.00, 95%, CI 0.99 to 1.02, p=0.54) or overall survival (HR=1.00, 95%, CI 0.99 to 1.02, p=0.45). High tumour stage, lymph node metastasis, high tumour grade and age at diagnosis were all independent prognostic factors for cancer-specific survival and overall survival. Conclusions: Ki-67 is only a moderate surrogate marker for HPV infection in PSCC. It does not show prognostic value for cancer-specific survival and overall survival in PSCC. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Clinical Pathology | - |
dc.title | The prognostic value of Ki-67 expression in penile squamous cell carcinoma | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1136/jclinpath-2011-200638 | - |
dc.identifier.pmid | 22447920 | - |
dc.identifier.scopus | eid_2-s2.0-84861826960 | - |
dc.identifier.volume | 65 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 534 | - |
dc.identifier.epage | 537 | - |
dc.identifier.eissn | 1472-4146 | - |
dc.identifier.isi | WOS:000304609900010 | - |
dc.identifier.issnl | 0021-9746 | - |