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Article: Molecular regulation of apoptosis in fast plantaris muscles of aged rats

TitleMolecular regulation of apoptosis in fast plantaris muscles of aged rats
Authors
Issue Date2006
Citation
Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 2006, v. 61, n. 3, p. 245-255 How to Cite?
AbstractThis study tested the hypothesis that aging exacerbates apoptotic signaling in rat fast plantaris muscle during muscle unloading. Plantaris muscle mass was 22% lower in aged animals and the apoptotic index was 600% higher, when compared to those in young adult animals. Following 14 days of hind-limb unloading, absolute plantaris muscle mass was 20% lower in young adult animals with a corresponding 200% higher elevation of the apoptotic index. Unloading had no affect on muscle weight or apoptotic index of aged plantaris muscles. The changes in proapoptotic messenger RNA (mRNA) for apoptotic protease activating factor-1 (Apaf-1), Bax, and inhibitor of differentiation protein-2 (Id2) were exacerbated with aging. Bax and Bcl-2 protein levels were also altered differently in aged muscle, compared to young. Significant positive correlations were observed between the changes in Id2 and Bax mRNA, and Id2 and caspase-9 mRNA. These data suggest that a pro-apoptotic environment may contribute to aging-associated atrophy in fast skeletal muscle, but apoptotic signaling differs by age. Copyright 2006 by The Gerontological Society of America.
Persistent Identifierhttp://hdl.handle.net/10722/244082
ISSN
2015 Impact Factor: 5.476
2015 SCImago Journal Rankings: 2.675

 

DC FieldValueLanguage
dc.contributor.authorPistilli, Emidio E.-
dc.contributor.authorSiu, Parco M.-
dc.contributor.authorAlway, Stephen E.-
dc.date.accessioned2017-08-31T08:55:59Z-
dc.date.available2017-08-31T08:55:59Z-
dc.date.issued2006-
dc.identifier.citationJournals of Gerontology - Series A Biological Sciences and Medical Sciences, 2006, v. 61, n. 3, p. 245-255-
dc.identifier.issn1079-5006-
dc.identifier.urihttp://hdl.handle.net/10722/244082-
dc.description.abstractThis study tested the hypothesis that aging exacerbates apoptotic signaling in rat fast plantaris muscle during muscle unloading. Plantaris muscle mass was 22% lower in aged animals and the apoptotic index was 600% higher, when compared to those in young adult animals. Following 14 days of hind-limb unloading, absolute plantaris muscle mass was 20% lower in young adult animals with a corresponding 200% higher elevation of the apoptotic index. Unloading had no affect on muscle weight or apoptotic index of aged plantaris muscles. The changes in proapoptotic messenger RNA (mRNA) for apoptotic protease activating factor-1 (Apaf-1), Bax, and inhibitor of differentiation protein-2 (Id2) were exacerbated with aging. Bax and Bcl-2 protein levels were also altered differently in aged muscle, compared to young. Significant positive correlations were observed between the changes in Id2 and Bax mRNA, and Id2 and caspase-9 mRNA. These data suggest that a pro-apoptotic environment may contribute to aging-associated atrophy in fast skeletal muscle, but apoptotic signaling differs by age. Copyright 2006 by The Gerontological Society of America.-
dc.languageeng-
dc.relation.ispartofJournals of Gerontology - Series A Biological Sciences and Medical Sciences-
dc.titleMolecular regulation of apoptosis in fast plantaris muscles of aged rats-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.pmid16567372-
dc.identifier.scopuseid_2-s2.0-33645972267-
dc.identifier.volume61-
dc.identifier.issue3-
dc.identifier.spage245-
dc.identifier.epage255-

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