File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.ejpb.2015.06.022
- Scopus: eid_2-s2.0-84936863437
- PMID: 26143368
- WOS: WOS:000359171300044
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Development of highly stabilized curcumin nanoparticles by flash nanoprecipitation and lyophilization
Title | Development of highly stabilized curcumin nanoparticles by flash nanoprecipitation and lyophilization |
---|---|
Authors | |
Keywords | Stability Atomic force microscopy Co-stabilizer Confined impinging jets-with-dilution mixer Curcumin nanoparticles Flash nanoprecipitation Lyophilization X-ray photoelectron spectroscopy |
Issue Date | 2015 |
Citation | European Journal of Pharmaceutics and Biopharmaceutics, 2015, v. 94, p. 436-449 How to Cite? |
Abstract | © 2015 Elsevier B.V. All rights reserved. The influence of critical operating parameters on the Flash Nanoprecipitation (FNP) and resulting material properties of curcumin (CUR) nanoparticles has been evaluated using a confined impinging jets-with-dilution mixer (CIJ-D-M). It has been shown that the mixing rate, molecular weight of polymeric stabilizer (i.e., polyethylene glycol-b-poly(dl-lactide) di-block copolymer; PEG-PLA) and drug-to-copolymer mass ratio all exert a significant impact on the particle size and stability of the generated nanosuspensions. The attainable mean particle size and span of the nanoparticles through optimization of these process parameters were approximately 70 nm and 0.85 respectively. However, the optimized nanosuspension was only stable for about two hours after preparation. Co-formulation with polyvinylpyrrolidone (PVP) substantially extended the product lifespan to 5 days at ambient conditions and two weeks at 4 °C. Results from zeta potential measurement and X-ray photoelectron spectroscopy (XPS) suggested that the enhanced stability is probably due to the formation of an additional protective barrier by PVP around the particle surface, thereby suppressing the dissociation of PEG-PLA from the particles and preventing CUR leakage from inside. Long-term storage stability ( > 1 year) could be achieved by lyophilization of the optimized nanosuspension with Kleptose (hydroxypropyl-β-cyclodextrin), which was shown to be the only effective lyoprotectant among all the ones tested for the CUR nanoparticles. At an optimal concentration of Kleptose (1.25% w/v), the redispersibility (S < inf > f < /inf > /S < inf > i < /inf > ; ratio of the final and initial particle sizes) and encapsulation efficiency of lyophilized CUR nanoparticles were about 1.22% and 94%, respectively. |
Persistent Identifier | http://hdl.handle.net/10722/244051 |
ISSN | 2023 Impact Factor: 4.4 2023 SCImago Journal Rankings: 0.835 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chow, Shing Fung | - |
dc.contributor.author | Wan, Ka Yee | - |
dc.contributor.author | Cheng, Kwok Kin | - |
dc.contributor.author | Wong, Ka Wai | - |
dc.contributor.author | Sun, Changquan Calvin | - |
dc.contributor.author | Baum, Larry | - |
dc.contributor.author | Chow, Albert Hee Lum | - |
dc.date.accessioned | 2017-08-31T08:55:54Z | - |
dc.date.available | 2017-08-31T08:55:54Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | European Journal of Pharmaceutics and Biopharmaceutics, 2015, v. 94, p. 436-449 | - |
dc.identifier.issn | 0939-6411 | - |
dc.identifier.uri | http://hdl.handle.net/10722/244051 | - |
dc.description.abstract | © 2015 Elsevier B.V. All rights reserved. The influence of critical operating parameters on the Flash Nanoprecipitation (FNP) and resulting material properties of curcumin (CUR) nanoparticles has been evaluated using a confined impinging jets-with-dilution mixer (CIJ-D-M). It has been shown that the mixing rate, molecular weight of polymeric stabilizer (i.e., polyethylene glycol-b-poly(dl-lactide) di-block copolymer; PEG-PLA) and drug-to-copolymer mass ratio all exert a significant impact on the particle size and stability of the generated nanosuspensions. The attainable mean particle size and span of the nanoparticles through optimization of these process parameters were approximately 70 nm and 0.85 respectively. However, the optimized nanosuspension was only stable for about two hours after preparation. Co-formulation with polyvinylpyrrolidone (PVP) substantially extended the product lifespan to 5 days at ambient conditions and two weeks at 4 °C. Results from zeta potential measurement and X-ray photoelectron spectroscopy (XPS) suggested that the enhanced stability is probably due to the formation of an additional protective barrier by PVP around the particle surface, thereby suppressing the dissociation of PEG-PLA from the particles and preventing CUR leakage from inside. Long-term storage stability ( > 1 year) could be achieved by lyophilization of the optimized nanosuspension with Kleptose (hydroxypropyl-β-cyclodextrin), which was shown to be the only effective lyoprotectant among all the ones tested for the CUR nanoparticles. At an optimal concentration of Kleptose (1.25% w/v), the redispersibility (S < inf > f < /inf > /S < inf > i < /inf > ; ratio of the final and initial particle sizes) and encapsulation efficiency of lyophilized CUR nanoparticles were about 1.22% and 94%, respectively. | - |
dc.language | eng | - |
dc.relation.ispartof | European Journal of Pharmaceutics and Biopharmaceutics | - |
dc.subject | Stability | - |
dc.subject | Atomic force microscopy | - |
dc.subject | Co-stabilizer | - |
dc.subject | Confined impinging jets-with-dilution mixer | - |
dc.subject | Curcumin nanoparticles | - |
dc.subject | Flash nanoprecipitation | - |
dc.subject | Lyophilization | - |
dc.subject | X-ray photoelectron spectroscopy | - |
dc.title | Development of highly stabilized curcumin nanoparticles by flash nanoprecipitation and lyophilization | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.ejpb.2015.06.022 | - |
dc.identifier.pmid | 26143368 | - |
dc.identifier.scopus | eid_2-s2.0-84936863437 | - |
dc.identifier.volume | 94 | - |
dc.identifier.spage | 436 | - |
dc.identifier.epage | 449 | - |
dc.identifier.eissn | 1873-3441 | - |
dc.identifier.isi | WOS:000359171300044 | - |
dc.identifier.issnl | 0939-6411 | - |