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Article: Coexistence of Ductal Carcinoma Within Mammary Phyllodes Tumor: A Review of 557 Cases From a 20-year Region-wide Database in Hong Kong and Southern China

TitleCoexistence of Ductal Carcinoma Within Mammary Phyllodes Tumor: A Review of 557 Cases From a 20-year Region-wide Database in Hong Kong and Southern China
Authors
KeywordsBreast neoplasms
Carcinoma
Incidence
Intraductal
Noninfiltrating
Issue Date2017
PublisherElsevier Inc. The Journal's web site is located at http://www.clinical-breast-cancer.com
Citation
Clinical Breast Cancer, 2017, v. 18 n. 3, p. e421-e425 How to Cite?
AbstractIntroduction Phyllodes tumor (PT) is an uncommon fibroepithelial tumor of the breast showing predominately proliferation of the stromal component. The presence of ductal carcinoma in situ (DCIS) or invasive ductal carcinoma is rare, with only a few cases reported in the literature. Methods A retrospective review of a prospectively maintained database was performed. Patients who were treated for PT in 5 hospitals in Hong Kong and Shenzhen, China over a period of 20 years (1997-2016) were evaluated. All pathology slides were reported by specialist pathologists. Patients with coexisting ductal carcinoma were identified. Results A total of 557 patients were included in this cohort; 363 (65.2%) patients had benign PT, 130 (23.3%) had borderline PT, and 64 (11.5%) had malignant PT. There were 6 (1.1%) patients with coexisting ductal carcinoma in the PT; 5 were DCIS and 1 was invasive ductal carcinoma. The median age was 46.5 years (range, 25-54 years). Ductal carcinoma occurred more frequently in malignant PT than in benign or borderline PT (4.7% vs. 0.6%; P = .02). However, malignant PT was not associated with higher DCIS grade (P = .1). All patients underwent surgery with clear resection margins. After a median follow-up interval of 70 months (range, 2-101 months), all patients remained disease- and recurrence-free. Conclusion We report 6 additional uncommon cases of ductal carcinoma complicating PT. The presence of ductal carcinoma was not adverse prognosticator as these are usually incidental and situated within the harboring PT.
Persistent Identifierhttp://hdl.handle.net/10722/243882
ISSN
2019 Impact Factor: 2.647
2015 SCImago Journal Rankings: 1.030
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorCo, THM-
dc.contributor.authorTse, GM-
dc.contributor.authorChen, C-
dc.contributor.authorWei, J-
dc.contributor.authorKwong, A-
dc.date.accessioned2017-08-25T03:00:45Z-
dc.date.available2017-08-25T03:00:45Z-
dc.date.issued2017-
dc.identifier.citationClinical Breast Cancer, 2017, v. 18 n. 3, p. e421-e425-
dc.identifier.issn1526-8209-
dc.identifier.urihttp://hdl.handle.net/10722/243882-
dc.description.abstractIntroduction Phyllodes tumor (PT) is an uncommon fibroepithelial tumor of the breast showing predominately proliferation of the stromal component. The presence of ductal carcinoma in situ (DCIS) or invasive ductal carcinoma is rare, with only a few cases reported in the literature. Methods A retrospective review of a prospectively maintained database was performed. Patients who were treated for PT in 5 hospitals in Hong Kong and Shenzhen, China over a period of 20 years (1997-2016) were evaluated. All pathology slides were reported by specialist pathologists. Patients with coexisting ductal carcinoma were identified. Results A total of 557 patients were included in this cohort; 363 (65.2%) patients had benign PT, 130 (23.3%) had borderline PT, and 64 (11.5%) had malignant PT. There were 6 (1.1%) patients with coexisting ductal carcinoma in the PT; 5 were DCIS and 1 was invasive ductal carcinoma. The median age was 46.5 years (range, 25-54 years). Ductal carcinoma occurred more frequently in malignant PT than in benign or borderline PT (4.7% vs. 0.6%; P = .02). However, malignant PT was not associated with higher DCIS grade (P = .1). All patients underwent surgery with clear resection margins. After a median follow-up interval of 70 months (range, 2-101 months), all patients remained disease- and recurrence-free. Conclusion We report 6 additional uncommon cases of ductal carcinoma complicating PT. The presence of ductal carcinoma was not adverse prognosticator as these are usually incidental and situated within the harboring PT.-
dc.languageeng-
dc.publisherElsevier Inc. The Journal's web site is located at http://www.clinical-breast-cancer.com-
dc.relation.ispartofClinical Breast Cancer-
dc.rightsPosting accepted manuscript (postprint): © <year>. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/-
dc.subjectBreast neoplasms-
dc.subjectCarcinoma-
dc.subjectIncidence-
dc.subjectIntraductal-
dc.subjectNoninfiltrating-
dc.titleCoexistence of Ductal Carcinoma Within Mammary Phyllodes Tumor: A Review of 557 Cases From a 20-year Region-wide Database in Hong Kong and Southern China-
dc.typeArticle-
dc.identifier.emailCo, THM: mcth@hku.hk-
dc.identifier.emailKwong, A: avakwong@hku.hk-
dc.identifier.authorityCo, THM=rp02101-
dc.identifier.authorityKwong, A=rp01734-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.clbc.2017.06.001-
dc.identifier.pmid28689011-
dc.identifier.scopuseid_2-s2.0-85021812020-
dc.identifier.hkuros275581-
dc.identifier.volume18-
dc.identifier.issue3-
dc.identifier.spagee421-
dc.identifier.epagee425-
dc.identifier.isiWOS:000432986200023-
dc.publisher.placeUnited States-
dc.identifier.issnl1526-8209-

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