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Article: Importance of surgical margin in the outcomes of hepatocholangiocarcinoma
Title | Importance of surgical margin in the outcomes of hepatocholangiocarcinoma |
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Authors | |
Keywords | Hepatocholangiocarcinoma Hepatocellular cholangiocarcinoma Survival Hepatectomy Resection margin |
Issue Date | 2017 |
Publisher | Baishideng Publishing Group Co., Ltd. The Journal's web site is located at http://www.wjgnet.com/1948-5182/index.htm |
Citation | World Journal of Hepatology, 2017, v. 9 n. 13, p. 635-641 How to Cite? |
Abstract | Aim: To evaluate the significance of resection margin width in the management of hepatocholangiocarcinoma (HCC-CC).
Methods: Data of consecutive patients who underwent hepatectomy for hepatic malignancies in the period from 1995 to 2014 were reviewed. Patients with pathologically confirmed HCC-CC were included for analysis. Demographic, biochemical, operative and pathological data were analyzed against survival outcomes.
Results: Forty-two patients were included for analysis. The median age was 53.5 years. There were 29 males. Hepatitis B virus was identified in 73.8% of the patients. Most patients had preserved liver function. The median preoperative indocyanine green retention rate at 15 min was 10.2%. The median tumor size was 6.5 cm. Major hepatectomy was required in over 70% of the patients. Hepaticojejunostomy was performed in 6 patients. No hospital death occurred. The median hospital stay was 13 d. The median follow-up period was 32 mo. The 5-year disease-free survival and overall survival were 23.6% and 35.4% respectively. Multifocality was the only independent factor associated with disease-free survival [P < 0.001, odds ratio 4, 95% confidence interval (CI): 1.9-8.0]. In patients with multifocal tumor (n = 20), resection margin of ≥ 1 cm was associated with improved 1-year disease-free survival (40% vs 0%; log-rank, P = 0.012).
Conclusion: HCC-CC is a rare disease with poor prognosis. Resection margin of 1 cm or above was associated with improved survival outcome in patients with multifocal HCC-CC. |
Persistent Identifier | http://hdl.handle.net/10722/243858 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.673 |
PubMed Central ID | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ma, KW | - |
dc.contributor.author | Chok, KSH | - |
dc.date.accessioned | 2017-08-25T03:00:26Z | - |
dc.date.available | 2017-08-25T03:00:26Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | World Journal of Hepatology, 2017, v. 9 n. 13, p. 635-641 | - |
dc.identifier.issn | 1948-5182 | - |
dc.identifier.uri | http://hdl.handle.net/10722/243858 | - |
dc.description.abstract | Aim: To evaluate the significance of resection margin width in the management of hepatocholangiocarcinoma (HCC-CC). Methods: Data of consecutive patients who underwent hepatectomy for hepatic malignancies in the period from 1995 to 2014 were reviewed. Patients with pathologically confirmed HCC-CC were included for analysis. Demographic, biochemical, operative and pathological data were analyzed against survival outcomes. Results: Forty-two patients were included for analysis. The median age was 53.5 years. There were 29 males. Hepatitis B virus was identified in 73.8% of the patients. Most patients had preserved liver function. The median preoperative indocyanine green retention rate at 15 min was 10.2%. The median tumor size was 6.5 cm. Major hepatectomy was required in over 70% of the patients. Hepaticojejunostomy was performed in 6 patients. No hospital death occurred. The median hospital stay was 13 d. The median follow-up period was 32 mo. The 5-year disease-free survival and overall survival were 23.6% and 35.4% respectively. Multifocality was the only independent factor associated with disease-free survival [P < 0.001, odds ratio 4, 95% confidence interval (CI): 1.9-8.0]. In patients with multifocal tumor (n = 20), resection margin of ≥ 1 cm was associated with improved 1-year disease-free survival (40% vs 0%; log-rank, P = 0.012). Conclusion: HCC-CC is a rare disease with poor prognosis. Resection margin of 1 cm or above was associated with improved survival outcome in patients with multifocal HCC-CC. | - |
dc.language | eng | - |
dc.publisher | Baishideng Publishing Group Co., Ltd. The Journal's web site is located at http://www.wjgnet.com/1948-5182/index.htm | - |
dc.relation.ispartof | World Journal of Hepatology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Hepatocholangiocarcinoma | - |
dc.subject | Hepatocellular cholangiocarcinoma | - |
dc.subject | Survival | - |
dc.subject | Hepatectomy | - |
dc.subject | Resection margin | - |
dc.title | Importance of surgical margin in the outcomes of hepatocholangiocarcinoma | - |
dc.type | Article | - |
dc.identifier.email | Chok, KSH: chok6275@hku.hk | - |
dc.identifier.authority | Chok, KSH=rp02110 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.4254/wjh.v9.i13.635 | - |
dc.identifier.pmid | 28539991 | - |
dc.identifier.pmcid | PMC5424293 | - |
dc.identifier.scopus | eid_2-s2.0-85019034257 | - |
dc.identifier.hkuros | 274783 | - |
dc.identifier.volume | 9 | - |
dc.identifier.issue | 13 | - |
dc.identifier.spage | 635 | - |
dc.identifier.epage | 641 | - |
dc.identifier.isi | WOS:000403895000003 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1948-5182 | - |