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Article: Human Infection with Highly Pathogenic Avian Influenza A(H7N9) Virus, China

TitleHuman Infection with Highly Pathogenic Avian Influenza A(H7N9) Virus, China
Authors
Issue Date2017
PublisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm
Citation
Emerging Infectious Diseases, 2017, v. 23 n. 8, p. 1332-1340 How to Cite?
AbstractThe recent increase in zoonotic avian influenza A(H7N9) disease in China is a cause of public health concern. Most of the A(H7N9) viruses previously reported have been of low pathogenicity. We report the fatal case of a patient in China who was infected with an A(H7N9) virus having a polybasic amino acid sequence at its hemagglutinin cleavage site (PEVPKRKRTAR/GL), a sequence suggestive of high pathogenicity in birds. Its neuraminidase also had R292K, an amino acid change known to be associated with neuraminidase inhibitor resistance. Both of these molecular features might have contributed to the patient's adverse clinical outcome. The patient had a history of exposure to sick and dying poultry, and his close contacts had no evidence of A(H7N9) disease, suggesting human-to-human transmission did not occur. Enhanced surveillance is needed to determine whether this highly pathogenic avian influenza A(H7N9) virus will continue to spread.
Persistent Identifierhttp://hdl.handle.net/10722/243736
ISSN
2017 Impact Factor: 7.422
2015 SCImago Journal Rankings: 3.023
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorKe, C-
dc.contributor.authorMok, KP-
dc.contributor.authorZhu, W-
dc.contributor.authorZhou, H-
dc.contributor.authorHe, J-
dc.contributor.authorGuan, W-
dc.contributor.authorWu, J-
dc.contributor.authorSong, W-
dc.contributor.authorWang, D-
dc.contributor.authorLiu, J-
dc.contributor.authorLin, Q-
dc.contributor.authorChu, KW-
dc.contributor.authorYang, L-
dc.contributor.authorZhong, N-
dc.contributor.authorYang, Z-
dc.contributor.authorShu, Y-
dc.contributor.authorPeiris, JSM-
dc.date.accessioned2017-08-25T02:58:51Z-
dc.date.available2017-08-25T02:58:51Z-
dc.date.issued2017-
dc.identifier.citationEmerging Infectious Diseases, 2017, v. 23 n. 8, p. 1332-1340-
dc.identifier.issn1080-6040-
dc.identifier.urihttp://hdl.handle.net/10722/243736-
dc.description.abstractThe recent increase in zoonotic avian influenza A(H7N9) disease in China is a cause of public health concern. Most of the A(H7N9) viruses previously reported have been of low pathogenicity. We report the fatal case of a patient in China who was infected with an A(H7N9) virus having a polybasic amino acid sequence at its hemagglutinin cleavage site (PEVPKRKRTAR/GL), a sequence suggestive of high pathogenicity in birds. Its neuraminidase also had R292K, an amino acid change known to be associated with neuraminidase inhibitor resistance. Both of these molecular features might have contributed to the patient's adverse clinical outcome. The patient had a history of exposure to sick and dying poultry, and his close contacts had no evidence of A(H7N9) disease, suggesting human-to-human transmission did not occur. Enhanced surveillance is needed to determine whether this highly pathogenic avian influenza A(H7N9) virus will continue to spread.-
dc.languageeng-
dc.publisherUS Department of Health and Human Services, Centers for Disease Control and Prevention. The Journal's web site is located at http://www.cdc.gov/ncidod/EID/index.htm-
dc.relation.ispartofEmerging Infectious Diseases-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleHuman Infection with Highly Pathogenic Avian Influenza A(H7N9) Virus, China-
dc.typeArticle-
dc.identifier.emailMok, KP: ch02mkp@hkucc.hku.hk-
dc.identifier.emailChu, KW: dkwchu@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.authorityMok, KP=rp01805-
dc.identifier.authorityChu, KW=rp02512-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3201/eid2308.170600-
dc.identifier.pmid28580899-
dc.identifier.scopuseid_2-s2.0-85025107232-
dc.identifier.hkuros274160-
dc.identifier.volume23-
dc.identifier.issue8-
dc.identifier.spage1332-
dc.identifier.epage1340-
dc.identifier.isiWOS:000405673200013-
dc.publisher.placeUnited States-

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