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Article: The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome Activity
Title | The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome Activity |
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Authors | |
Issue Date | 2016 |
Publisher | Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/oximed/ |
Citation | Oxidative Medicine and Cellular Longevity, 2016, v. 2016, p. 4693703:1-16 How to Cite? |
Abstract | Excessive reactive oxygen species/reactive nitrogen species (ROS/RNS) produced as a result of ageing causes damage to macromolecules and organelles or leads to interference of cell signalling pathways, which in turn results in oxidative stress. Oxidative stress occurs in many neurodegenerative diseases (e.g., Parkinson’s disease) and contributes to progressive neuronal loss. In this study, we show that cell apoptosis is induced by oxidative stress and that lysosomes play an important role in cell survival under oxidative stress. As a compensatory response to this stress, lysosomal genes were upregulated via induction of transcription factor EB (TFEB). In addition, localization of TFEB to the nucleus was increased by oxidative stress. We also confirmed that TFEB protects cells from oxidative stress both in vitro and in vivo. Finally, we found that C-ETS2 senses oxidative stress, activates TFEB transcription, and mediates the upregulation of lysosomal genes. Our results demonstrate a mechanistic pathway for inducing lysosomal activity during ageing and neurodegeneration. |
Persistent Identifier | http://hdl.handle.net/10722/243567 |
ISSN | 2021 Impact Factor: 7.310 2023 SCImago Journal Rankings: 1.477 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Ma, S | - |
dc.contributor.author | Fang, Z | - |
dc.contributor.author | Luo, W | - |
dc.contributor.author | Yang, Y | - |
dc.contributor.author | Wang, C | - |
dc.contributor.author | Zhang, Q | - |
dc.contributor.author | Wang, H | - |
dc.contributor.author | Chen, H | - |
dc.contributor.author | Chan, CB | - |
dc.contributor.author | Liu, Z | - |
dc.date.accessioned | 2017-08-25T02:56:34Z | - |
dc.date.available | 2017-08-25T02:56:34Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Oxidative Medicine and Cellular Longevity, 2016, v. 2016, p. 4693703:1-16 | - |
dc.identifier.issn | 1942-0900 | - |
dc.identifier.uri | http://hdl.handle.net/10722/243567 | - |
dc.description.abstract | Excessive reactive oxygen species/reactive nitrogen species (ROS/RNS) produced as a result of ageing causes damage to macromolecules and organelles or leads to interference of cell signalling pathways, which in turn results in oxidative stress. Oxidative stress occurs in many neurodegenerative diseases (e.g., Parkinson’s disease) and contributes to progressive neuronal loss. In this study, we show that cell apoptosis is induced by oxidative stress and that lysosomes play an important role in cell survival under oxidative stress. As a compensatory response to this stress, lysosomal genes were upregulated via induction of transcription factor EB (TFEB). In addition, localization of TFEB to the nucleus was increased by oxidative stress. We also confirmed that TFEB protects cells from oxidative stress both in vitro and in vivo. Finally, we found that C-ETS2 senses oxidative stress, activates TFEB transcription, and mediates the upregulation of lysosomal genes. Our results demonstrate a mechanistic pathway for inducing lysosomal activity during ageing and neurodegeneration. | - |
dc.language | eng | - |
dc.publisher | Hindawi Publishing Corporation. The Journal's web site is located at http://www.hindawi.com/journals/oximed/ | - |
dc.relation.ispartof | Oxidative Medicine and Cellular Longevity | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.title | The C-ETS2-TFEB Axis Promotes Neuron Survival under Oxidative Stress by Regulating Lysosome Activity | - |
dc.type | Article | - |
dc.identifier.email | Chan, CB: chancb@hku.hk | - |
dc.identifier.authority | Chan, CB=rp02140 | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.1155/2016/4693703 | - |
dc.identifier.scopus | eid_2-s2.0-84971433440 | - |
dc.identifier.hkuros | 274299 | - |
dc.identifier.volume | 2016 | - |
dc.identifier.spage | 4693703:1 | - |
dc.identifier.epage | 16 | - |
dc.identifier.isi | WOS:000377047300001 | - |
dc.publisher.place | United States | - |
dc.identifier.issnl | 1942-0994 | - |