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Article: Long-range projections coordinate distributed brain-wide neural activity with a specific spatiotemporal profile

TitleLong-range projections coordinate distributed brain-wide neural activity with a specific spatiotemporal profile
Authors
Issue Date2016
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings of the National Academy of Sciences, 2016, v. 113 n. 51, p. E8306-E8315 How to Cite?
AbstractOne challenge in contemporary neuroscience is to achieve an integrated understanding of the large-scale brain-wide interactions, particularly the spatiotemporal patterns of neural activity that give rise to functions and behavior. At present, little is known about the spatiotemporal properties of long-range neuronal networks. We examined brain-wide neural activity patterns elicited by stimulating ventral posteromedial (VPM) thalamo-cortical excitatory neurons through combined optogenetic stimulation and functional MRI (fMRI). We detected robust optogenetically evoked fMRI activation bilaterally in primary visual, somatosensory, and auditory cortices at low (1 Hz) but not high frequencies (5–40 Hz). Subsequent electrophysiological recordings indicated interactions over long temporal windows across thalamo-cortical, cortico-cortical, and interhemispheric callosal projections at low frequencies. We further observed enhanced visually evoked fMRI activation during and after VPM stimulation in the superior colliculus, indicating that visual processing was subcortically modulated by low-frequency activity originating from VPM. Stimulating posteromedial complex thalamo-cortical excitatory neurons also evoked brain-wide blood-oxygenation-level–dependent activation, although with a distinct spatiotemporal profile. Our results directly demonstrate that low-frequency activity governs large-scale, brain-wide connectivity and interactions through long-range excitatory projections to coordinate the functional integration of remote brain regions. This low-frequency phenomenon contributes to the neural basis of long-range functional connectivity as measured by resting-state fMRI.
Persistent Identifierhttp://hdl.handle.net/10722/242940
ISSN
2017 Impact Factor: 9.504
2015 SCImago Journal Rankings: 6.883
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorLeong, TL-
dc.contributor.authorChan, RW-
dc.contributor.authorGao, P-
dc.contributor.authorChan, YS-
dc.contributor.authorTsia, KKM-
dc.contributor.authorYung, WH-
dc.contributor.authorWu, EX-
dc.date.accessioned2017-08-25T02:47:37Z-
dc.date.available2017-08-25T02:47:37Z-
dc.date.issued2016-
dc.identifier.citationProceedings of the National Academy of Sciences, 2016, v. 113 n. 51, p. E8306-E8315-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10722/242940-
dc.description.abstractOne challenge in contemporary neuroscience is to achieve an integrated understanding of the large-scale brain-wide interactions, particularly the spatiotemporal patterns of neural activity that give rise to functions and behavior. At present, little is known about the spatiotemporal properties of long-range neuronal networks. We examined brain-wide neural activity patterns elicited by stimulating ventral posteromedial (VPM) thalamo-cortical excitatory neurons through combined optogenetic stimulation and functional MRI (fMRI). We detected robust optogenetically evoked fMRI activation bilaterally in primary visual, somatosensory, and auditory cortices at low (1 Hz) but not high frequencies (5–40 Hz). Subsequent electrophysiological recordings indicated interactions over long temporal windows across thalamo-cortical, cortico-cortical, and interhemispheric callosal projections at low frequencies. We further observed enhanced visually evoked fMRI activation during and after VPM stimulation in the superior colliculus, indicating that visual processing was subcortically modulated by low-frequency activity originating from VPM. Stimulating posteromedial complex thalamo-cortical excitatory neurons also evoked brain-wide blood-oxygenation-level–dependent activation, although with a distinct spatiotemporal profile. Our results directly demonstrate that low-frequency activity governs large-scale, brain-wide connectivity and interactions through long-range excitatory projections to coordinate the functional integration of remote brain regions. This low-frequency phenomenon contributes to the neural basis of long-range functional connectivity as measured by resting-state fMRI.-
dc.languageeng-
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org-
dc.relation.ispartofProceedings of the National Academy of Sciences-
dc.rightsProceedings of the National Academy of Sciences. Copyright © National Academy of Sciences.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleLong-range projections coordinate distributed brain-wide neural activity with a specific spatiotemporal profile-
dc.typeArticle-
dc.identifier.emailChan, RW: russchan@connect.hku.hk-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.emailTsia, KKM: tsia@hku.hk-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.identifier.authorityChan, YS=rp00318-
dc.identifier.authorityTsia, KKM=rp01389-
dc.identifier.authorityWu, EX=rp00193-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1073/pnas.1616361113-
dc.identifier.pmcidPMC5187697-
dc.identifier.scopuseid_2-s2.0-85006511836-
dc.identifier.hkuros275526-
dc.identifier.hkuros278061-
dc.identifier.hkuros280466-
dc.identifier.volume113-
dc.identifier.issue51-
dc.identifier.spageE8306-
dc.identifier.epageE8315-
dc.identifier.isiWOS:000390044900011-
dc.publisher.placeUnited States-

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