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Article: Low frequency hippocampal-cortical activity drives brain-wide resting-state functional MRI connectivity

TitleLow frequency hippocampal-cortical activity drives brain-wide resting-state functional MRI connectivity
Authors
KeywordsFMRI
Hippocampus
Low frequency
Optogenetic
Resting-state functional connectivity
Issue Date2017
PublisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org
Citation
Proceedings of the National Academy of Sciences, 2017, v. 114 n. 33, p. E6972-E6981 How to Cite?
AbstractThe hippocampus, including the dorsal dentate gyrus (dDG), and cortex engage in bidirectional communication. We propose that low-frequency activity in hippocampal–cortical pathways contributes to brain-wide resting-state connectivity to integrate sensory information. Using optogenetic stimulation and brain-wide fMRI and resting-state fMRI (rsfMRI), we determined the large-scale effects of spatiotemporal-specific downstream propagation of hippocampal activity. Low-frequency (1 Hz), but not high-frequency (40 Hz), stimulation of dDG excitatory neurons evoked robust cortical and subcortical brain-wide fMRI responses. More importantly, it enhanced interhemispheric rsfMRI connectivity in various cortices and hippocampus. Subsequent local field potential recordings revealed an increase in slow oscillations in dorsal hippocampus and visual cortex, interhemispheric visual cortical connectivity, and hippocampal–cortical connectivity. Meanwhile, pharmacological inactivation of dDG neurons decreased interhemispheric rsfMRI connectivity. Functionally, visually evoked fMRI responses in visual regions also increased during and after low-frequency dDG stimulation. Together, our results indicate that low-frequency activity robustly propagates in the dorsal hippocampal–cortical pathway, drives interhemispheric cortical rsfMRI connectivity, and mediates visual processing.
Persistent Identifierhttp://hdl.handle.net/10722/242939
ISSN
2017 Impact Factor: 9.504
2015 SCImago Journal Rankings: 6.883
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChan, RW-
dc.contributor.authorLeong, TL-
dc.contributor.authorHo, CC-
dc.contributor.authorGao, P-
dc.contributor.authorWong, CS-
dc.contributor.authorDong, M-
dc.contributor.authorWang, X-
dc.contributor.authorHe, J-
dc.contributor.authorChan, YS-
dc.contributor.authorLim, LW-
dc.contributor.authorWu, EX-
dc.date.accessioned2017-08-25T02:47:36Z-
dc.date.available2017-08-25T02:47:36Z-
dc.date.issued2017-
dc.identifier.citationProceedings of the National Academy of Sciences, 2017, v. 114 n. 33, p. E6972-E6981-
dc.identifier.issn0027-8424-
dc.identifier.urihttp://hdl.handle.net/10722/242939-
dc.description.abstractThe hippocampus, including the dorsal dentate gyrus (dDG), and cortex engage in bidirectional communication. We propose that low-frequency activity in hippocampal–cortical pathways contributes to brain-wide resting-state connectivity to integrate sensory information. Using optogenetic stimulation and brain-wide fMRI and resting-state fMRI (rsfMRI), we determined the large-scale effects of spatiotemporal-specific downstream propagation of hippocampal activity. Low-frequency (1 Hz), but not high-frequency (40 Hz), stimulation of dDG excitatory neurons evoked robust cortical and subcortical brain-wide fMRI responses. More importantly, it enhanced interhemispheric rsfMRI connectivity in various cortices and hippocampus. Subsequent local field potential recordings revealed an increase in slow oscillations in dorsal hippocampus and visual cortex, interhemispheric visual cortical connectivity, and hippocampal–cortical connectivity. Meanwhile, pharmacological inactivation of dDG neurons decreased interhemispheric rsfMRI connectivity. Functionally, visually evoked fMRI responses in visual regions also increased during and after low-frequency dDG stimulation. Together, our results indicate that low-frequency activity robustly propagates in the dorsal hippocampal–cortical pathway, drives interhemispheric cortical rsfMRI connectivity, and mediates visual processing.-
dc.languageeng-
dc.publisherNational Academy of Sciences. The Journal's web site is located at http://www.pnas.org-
dc.relation.ispartofProceedings of the National Academy of Sciences-
dc.rightsProceedings of the National Academy of Sciences. Copyright © National Academy of Sciences.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectFMRI-
dc.subjectHippocampus-
dc.subjectLow frequency-
dc.subjectOptogenetic-
dc.subjectResting-state functional connectivity-
dc.titleLow frequency hippocampal-cortical activity drives brain-wide resting-state functional MRI connectivity-
dc.typeArticle-
dc.identifier.emailChan, RW: russchan@connect.hku.hk-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.emailLim, LW: limlw@hku.hk-
dc.identifier.emailWu, EX: ewu@eee.hku.hk-
dc.identifier.authorityChan, YS=rp00318-
dc.identifier.authorityLim, LW=rp02088-
dc.identifier.authorityWu, EX=rp00193-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.1073/pnas.1703309114-
dc.identifier.pmcidPMC5565425-
dc.identifier.scopuseid_2-s2.0-85027405086-
dc.identifier.hkuros275524-
dc.identifier.hkuros291128-
dc.identifier.hkuros291110-
dc.identifier.volume114-
dc.identifier.issue33-
dc.identifier.spageE6972-
dc.identifier.epageE6981-
dc.identifier.isiWOS:000407610400030-
dc.publisher.placeUnited States-

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