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Article: Preliminary epidemiologic assessment of human infections with highly pathogenic avian influenza A(H5N6) virus, China

TitlePreliminary epidemiologic assessment of human infections with highly pathogenic avian influenza A(H5N6) virus, China
Authors
KeywordsH5N6
H5N1
H7N9
Epidemiology
Issue Date2017
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/
Citation
Clinical Infectious Diseases, 2017, v. 65 n. 3, p. 383-388 How to Cite?
AbstractBackground. Since 2014, 17 human cases of infection with the newly emerged highly pathogenic avian influenza A(H5N6) virus have been identified in China to date. The epidemiologic characteristics of laboratory-confirmed A(H5N6) cases were compared to A(H5N1) and A(H7N9) cases in mainland China. Methods. Data on laboratory-confirmed H5N6, H5N1, and H7N9 cases identified in mainland China were analyzed to compare epidemiologic characteristics and clinical severity. Severity of confirmed H5N6, H5N1 and H7N9 cases was estimated based on the risk of severe outcomes in hospitalized cases. Results. H5N6 cases were older than H5N1 cases with a higher prevalence of underlying medical conditions but younger than H7N9 cases. Epidemiological time-to-event distributions were similar among cases infected with the 3 viruses. In comparison to a fatality risk of 70% (30/43) for hospitalized H5N1 cases and 41% (319/782) for hospitalized H7N9 cases, 12 (75%) out of the 16 hospitalized H5N6 cases were fatal, and 15 (94%) required mechanical ventilation. Conclusion. Similar epidemiologic characteristics and high severity were observed in cases of H5N6 and H5N1 virus infection, whereas severity of H7N9 virus infections appeared lower. Continued surveillance of human infections with avian influenza A viruses remains an essential component of pandemic influenza preparedness.
Persistent Identifierhttp://hdl.handle.net/10722/242864
ISSN
2017 Impact Factor: 9.117
2015 SCImago Journal Rankings: 4.742
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJiang, H-
dc.contributor.authorWu, P-
dc.contributor.authorUyeki, TM-
dc.contributor.authorHe, J-
dc.contributor.authorDeng, Z-
dc.contributor.authorXu, W-
dc.contributor.authorLv, Q-
dc.contributor.authorZhang, J-
dc.contributor.authorWu, Y-
dc.contributor.authorTsang, TK-
dc.contributor.authorKang, M-
dc.contributor.authorZheng, J-
dc.contributor.authorWang, L-
dc.contributor.authorYang, B-
dc.contributor.authorQin, Y-
dc.contributor.authorFeng, L-
dc.contributor.authorFang, VJ-
dc.contributor.authorGao, GF-
dc.contributor.authorLeung, GM-
dc.contributor.authorYu, H-
dc.contributor.authorCowling, BJ-
dc.date.accessioned2017-08-25T02:46:27Z-
dc.date.available2017-08-25T02:46:27Z-
dc.date.issued2017-
dc.identifier.citationClinical Infectious Diseases, 2017, v. 65 n. 3, p. 383-388-
dc.identifier.issn1058-4838-
dc.identifier.urihttp://hdl.handle.net/10722/242864-
dc.description.abstractBackground. Since 2014, 17 human cases of infection with the newly emerged highly pathogenic avian influenza A(H5N6) virus have been identified in China to date. The epidemiologic characteristics of laboratory-confirmed A(H5N6) cases were compared to A(H5N1) and A(H7N9) cases in mainland China. Methods. Data on laboratory-confirmed H5N6, H5N1, and H7N9 cases identified in mainland China were analyzed to compare epidemiologic characteristics and clinical severity. Severity of confirmed H5N6, H5N1 and H7N9 cases was estimated based on the risk of severe outcomes in hospitalized cases. Results. H5N6 cases were older than H5N1 cases with a higher prevalence of underlying medical conditions but younger than H7N9 cases. Epidemiological time-to-event distributions were similar among cases infected with the 3 viruses. In comparison to a fatality risk of 70% (30/43) for hospitalized H5N1 cases and 41% (319/782) for hospitalized H7N9 cases, 12 (75%) out of the 16 hospitalized H5N6 cases were fatal, and 15 (94%) required mechanical ventilation. Conclusion. Similar epidemiologic characteristics and high severity were observed in cases of H5N6 and H5N1 virus infection, whereas severity of H7N9 virus infections appeared lower. Continued surveillance of human infections with avian influenza A viruses remains an essential component of pandemic influenza preparedness.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/cid/-
dc.relation.ispartofClinical Infectious Diseases-
dc.rightsThis is a pre-copy-editing, author-produced PDF of an article accepted for publication in Clinical Infectious Diseases following peer review. The definitive publisher-authenticated version Clinical Infectious Diseases, 2017, v. 65 n. 3, p. 383-388 is available online at: https://doi.org/10.1093/cid/cix334-
dc.subjectH5N6-
dc.subjectH5N1-
dc.subjectH7N9-
dc.subjectEpidemiology-
dc.titlePreliminary epidemiologic assessment of human infections with highly pathogenic avian influenza A(H5N6) virus, China-
dc.typeArticle-
dc.identifier.emailWu, P: pengwu@hku.hk-
dc.identifier.emailTsang, TK: matklab@hku.hk-
dc.identifier.emailFang, VJ: vickyf@hku.hk-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.authorityWu, P=rp02025-
dc.identifier.authorityTsang, TK=rp02571-
dc.identifier.authorityLeung, GM=rp00460-
dc.identifier.authorityCowling, BJ=rp01326-
dc.description.naturepostprint-
dc.identifier.doi10.1093/cid/cix334-
dc.identifier.pmid28407105-
dc.identifier.pmcidPMC5848334-
dc.identifier.scopuseid_2-s2.0-85019639706-
dc.identifier.hkuros274072-
dc.identifier.volume65-
dc.identifier.issue3-
dc.identifier.spage383-
dc.identifier.epage388-
dc.identifier.isiWOS:000405501300004-
dc.publisher.placeUnited States-

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