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Conference Paper: Patients with Pre-Operative Hepatorenal Syndrome (HRS) Have Poorer Long-Term Survival Outcome after Living Donor Liver Transplantation (LDLT)

TitlePatients with Pre-Operative Hepatorenal Syndrome (HRS) Have Poorer Long-Term Survival Outcome after Living Donor Liver Transplantation (LDLT)
Authors
Issue Date2010
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021
Citation
International Liver Transplantation Society (ILTS) 16th Annual International Congress, Hong Kong, 16-19 June 2010. In Liver Transplantation, v. 16 n. Suppl. 1, p. S146, abstract no. P-94 How to Cite?
AbstractBackground: The aim of this retrospective review is to investigate whether patients with and without pre-operative hepatorenal syndrome (HRS) have comparable long-term survival outcome after live donor liver transplantation (LDLT). Methods: Patients who had LDLT done from July 1994 to December 2007 were included in the analysis. The median follow-up period was 55 months. First 50 cases and patients with HCC were excluded from analysis. Results: Total of 177 patients was included in which 34 of them (19.2%) had pre-operative HRS. Signifi cantly more patients with pre-operative HRS, compared to those without, had worse pre-operative liver function test, more pre-operative ICU admission (p<0.001) and early post-operative complications (p<0.001). Signifi cantly more patients with pre-operative type I HRS died during hospital stay (5 vs. 2; p=0.001). Intra-operative blood transfusion was signifi cantly higher (9 units vs. 4 units; p<0.001) and median day of stay in Intensive Care Unit (ICU) was signifi cantly longer in patients with type I HRS (8.5 days vs. 4 days, p=<0.001). The renal function test was signifi cantly worse in patients with pre-operative type I HRS at postoperative one year (Cr 108umol/L vs. Cr 100umol/L; p=0.004) but was comparable at postoperative fi ve year (Cr 101umol/L vs. Cr 88umol/L; p=0.145). There was signifi cantly worse overall survival in patients with pre-operative HRS (log-rank test, p= 0.000). Conclusion: Patients with type I HRS had more early post-operative complications and hospital mortality. They also had poorer long-term overall survival when compared to those without preoperative HRS.
DescriptionPoster Session I - Outcomes
Persistent Identifierhttp://hdl.handle.net/10722/241097
ISSN
2017 Impact Factor: 3.756
2015 SCImago Journal Rankings: 1.763

 

DC FieldValueLanguage
dc.contributor.authorChok, KSH-
dc.contributor.authorLo, CM-
dc.contributor.authorNg, KKC-
dc.contributor.authorChan, SC-
dc.contributor.authorSharr, WW-
dc.contributor.authorChan, ACY-
dc.contributor.authorFan, ST-
dc.date.accessioned2017-05-24T07:05:28Z-
dc.date.available2017-05-24T07:05:28Z-
dc.date.issued2010-
dc.identifier.citationInternational Liver Transplantation Society (ILTS) 16th Annual International Congress, Hong Kong, 16-19 June 2010. In Liver Transplantation, v. 16 n. Suppl. 1, p. S146, abstract no. P-94-
dc.identifier.issn1527-6465-
dc.identifier.urihttp://hdl.handle.net/10722/241097-
dc.descriptionPoster Session I - Outcomes-
dc.description.abstractBackground: The aim of this retrospective review is to investigate whether patients with and without pre-operative hepatorenal syndrome (HRS) have comparable long-term survival outcome after live donor liver transplantation (LDLT). Methods: Patients who had LDLT done from July 1994 to December 2007 were included in the analysis. The median follow-up period was 55 months. First 50 cases and patients with HCC were excluded from analysis. Results: Total of 177 patients was included in which 34 of them (19.2%) had pre-operative HRS. Signifi cantly more patients with pre-operative HRS, compared to those without, had worse pre-operative liver function test, more pre-operative ICU admission (p<0.001) and early post-operative complications (p<0.001). Signifi cantly more patients with pre-operative type I HRS died during hospital stay (5 vs. 2; p=0.001). Intra-operative blood transfusion was signifi cantly higher (9 units vs. 4 units; p<0.001) and median day of stay in Intensive Care Unit (ICU) was signifi cantly longer in patients with type I HRS (8.5 days vs. 4 days, p=<0.001). The renal function test was signifi cantly worse in patients with pre-operative type I HRS at postoperative one year (Cr 108umol/L vs. Cr 100umol/L; p=0.004) but was comparable at postoperative fi ve year (Cr 101umol/L vs. Cr 88umol/L; p=0.145). There was signifi cantly worse overall survival in patients with pre-operative HRS (log-rank test, p= 0.000). Conclusion: Patients with type I HRS had more early post-operative complications and hospital mortality. They also had poorer long-term overall survival when compared to those without preoperative HRS.-
dc.languageeng-
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jtoc/106570021-
dc.relation.ispartofLiver Transplantation-
dc.rightsLiver Transplantation. Copyright © John Wiley & Sons, Inc.-
dc.titlePatients with Pre-Operative Hepatorenal Syndrome (HRS) Have Poorer Long-Term Survival Outcome after Living Donor Liver Transplantation (LDLT)-
dc.typeConference_Paper-
dc.identifier.emailChok, KSH: chok6275@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.emailChan, SC: chanlsc@hku.hk-
dc.identifier.emailSharr, WW: wwsharr@hku.hk-
dc.identifier.emailChan, ACY: acchan@hku.hk-
dc.identifier.emailFan, ST: stfan@hku.hk-
dc.identifier.authorityChok, KSH=rp02110-
dc.identifier.authorityLo, CM=rp00412-
dc.identifier.authorityChan, SC=rp01568-
dc.identifier.authorityChan, ACY=rp00310-
dc.identifier.authorityFan, ST=rp00355-
dc.identifier.doi10.1002/lt.22086-
dc.identifier.volume16-
dc.identifier.issueSuppl. 1-
dc.identifier.spageS146-
dc.identifier.epageS146-
dc.publisher.placeUnited States-

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