Towards achieving the optimal SNR efficiency for 3D multi-shot diffusion-weighted echo-planar imaging

Abstract

Due to the assumption of 2D phase variations, the feasible maximum slab thickness is relatively thin (e.g. < 25 mm) for 3D multi-shot diffusion-weighted echo-planar imaging. We have thus proposed a new method in another study to correct for 3D inter-shot phase variations, thereby significantly increasing the feasible maximum slab thickness. In this study, we have demonstrated by simulations and experiments that slab thickness can be significantly increased to allow whole brain coverage with a TR that achieves optimal SNR efficiency.