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- Publisher Website: 10.1080/02656736.2017.1318456
- Scopus: eid_2-s2.0-85018827797
- PMID: 28540804
- WOS: WOS:000418118000003
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Article: High-intensity focused ablation (HIFU) of single benign thyroid nodule rarely alters underlying thyroid function
Title | High-intensity focused ablation (HIFU) of single benign thyroid nodule rarely alters underlying thyroid function |
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Authors | |
Keywords | focused ultrasound hypothyroidism thermal ablation thyroid dysfunction thyroid nodule |
Issue Date | 2017 |
Publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/02656736.asp |
Citation | International Journal of Hyperthermia, 2017, v. 33 n. 7, p. 875-881 How to Cite? |
Abstract | Background: High intensity focused ultrasound (HIFU) is a promising ablation technique for benign thyroid nodules. However, its effect on underlying thyroid function remains unknown. We aimed to evaluate the 6 months changes in serum thyroid stimulating hormone (TSH) and free thyroxine (FT4) after HIFU treatment. Methods: Eighty-three consecutive patients who underwent single HIFU ablation for symptomatic benign thyroid nodule were analysed. Eligible patients had serum TSH and FT4 checked before treatment (baseline), 1 week, 3 and 6 months following HIFU treatment. Primary endpoints were hypothyroidism (FT4 < 12 pmol/L) and hyperthyroidism (FT4 > 23 pmol/L) in the 6 months following treatment. To express extent of nodule ablation relative to the total gland volume, an ablation volume ratio was calculated by [(Ablated nodule volume/total thyroid volume)/(total thyroid volume)] × 100. Results: Relative to baseline, 1-week serum TSH significantly dropped (from 1.16 to 0.76 mIU/L, p < 0.001) while 1-week serum FT4 significantly rose (from 16.0 to 17.8 pmol/L, p < 0.001). However, 3- and 6-months TSH and FT4 did not changed significantly from baseline (p > 0.05). No patients developed hyperthyroidism while one (1.4%) developed hypothyroidism (FT4 = 11 pmol/L) at 3 months and 6 months. Interestingly, this patient had a previous lobectomy and an ablation volume ratio of 64.00%. Conclusions: Hypothyroidism following single HIFU ablation occurred rarely (1.4%) and resulted in little clinical relevance. Given that only one patient developed hypothyroidism following single HIFU ablation, it remains unclear how patients with different amount of parenchyma and relative extent of ablation may affect subsequent thyroid function. © 2017 Informa UK Limited, trading as Taylor & Francis Group. |
Persistent Identifier | http://hdl.handle.net/10722/240914 |
ISSN | 2023 Impact Factor: 3.0 2023 SCImago Journal Rankings: 0.827 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lang, HHB | - |
dc.contributor.author | Woo, YC | - |
dc.contributor.author | Chiu, WHK | - |
dc.date.accessioned | 2017-05-22T09:19:23Z | - |
dc.date.available | 2017-05-22T09:19:23Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | International Journal of Hyperthermia, 2017, v. 33 n. 7, p. 875-881 | - |
dc.identifier.issn | 0265-6736 | - |
dc.identifier.uri | http://hdl.handle.net/10722/240914 | - |
dc.description.abstract | Background: High intensity focused ultrasound (HIFU) is a promising ablation technique for benign thyroid nodules. However, its effect on underlying thyroid function remains unknown. We aimed to evaluate the 6 months changes in serum thyroid stimulating hormone (TSH) and free thyroxine (FT4) after HIFU treatment. Methods: Eighty-three consecutive patients who underwent single HIFU ablation for symptomatic benign thyroid nodule were analysed. Eligible patients had serum TSH and FT4 checked before treatment (baseline), 1 week, 3 and 6 months following HIFU treatment. Primary endpoints were hypothyroidism (FT4 < 12 pmol/L) and hyperthyroidism (FT4 > 23 pmol/L) in the 6 months following treatment. To express extent of nodule ablation relative to the total gland volume, an ablation volume ratio was calculated by [(Ablated nodule volume/total thyroid volume)/(total thyroid volume)] × 100. Results: Relative to baseline, 1-week serum TSH significantly dropped (from 1.16 to 0.76 mIU/L, p < 0.001) while 1-week serum FT4 significantly rose (from 16.0 to 17.8 pmol/L, p < 0.001). However, 3- and 6-months TSH and FT4 did not changed significantly from baseline (p > 0.05). No patients developed hyperthyroidism while one (1.4%) developed hypothyroidism (FT4 = 11 pmol/L) at 3 months and 6 months. Interestingly, this patient had a previous lobectomy and an ablation volume ratio of 64.00%. Conclusions: Hypothyroidism following single HIFU ablation occurred rarely (1.4%) and resulted in little clinical relevance. Given that only one patient developed hypothyroidism following single HIFU ablation, it remains unclear how patients with different amount of parenchyma and relative extent of ablation may affect subsequent thyroid function. © 2017 Informa UK Limited, trading as Taylor & Francis Group. | - |
dc.language | eng | - |
dc.publisher | Informa Healthcare. The Journal's web site is located at http://www.tandf.co.uk/journals/titles/02656736.asp | - |
dc.relation.ispartof | International Journal of Hyperthermia | - |
dc.rights | International Journal of Hyperthermia. Copyright © Informa Healthcare. | - |
dc.subject | focused ultrasound | - |
dc.subject | hypothyroidism | - |
dc.subject | thermal ablation | - |
dc.subject | thyroid dysfunction | - |
dc.subject | thyroid nodule | - |
dc.title | High-intensity focused ablation (HIFU) of single benign thyroid nodule rarely alters underlying thyroid function | - |
dc.type | Article | - |
dc.identifier.email | Lang, HHB: Blang@hku.hk | - |
dc.identifier.email | Woo, YC: wooyucho@hku.hk | - |
dc.identifier.email | Chiu, WHK: kwhchiu@hku.hk | - |
dc.identifier.authority | Lang, HHB=rp01828 | - |
dc.identifier.authority | Chiu, WHK=rp02074 | - |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.doi | 10.1080/02656736.2017.1318456 | - |
dc.identifier.pmid | 28540804 | - |
dc.identifier.scopus | eid_2-s2.0-85018827797 | - |
dc.identifier.hkuros | 272159 | - |
dc.identifier.volume | 33 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 875 | - |
dc.identifier.epage | 881 | - |
dc.identifier.isi | WOS:000418118000003 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0265-6736 | - |