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postgraduate thesis: The effect of sevoflurane on cognitive and synaptic function

TitleThe effect of sevoflurane on cognitive and synaptic function
Authors
Issue Date2016
PublisherThe University of Hong Kong (Pokfulam, Hong Kong)
Citation
Leung, W. Y. [梁詠恩]. (2016). The effect of sevoflurane on cognitive and synaptic function. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR.
AbstractAdvances in surgical and anaesthetic care have improved long term survival after surgery but in doing so have uncovered incidentally the phenomenon of postoperative cognitive dysfunction (POCD). The mechanisms underlying the development of POCD is still not fully elucidated but is currently thought to involve systemic inflammation induced surgical trauma, leading to neuroinflammation. As surgery almost always requires to be performed under anaesthesia, it is of great interest to evaluate any effects and/or interaction, if any, between anaesthesia and surgically induced systemic inflammation has on cognitive and synaptic function. This in turn might provide insights into the development and progression of POCD. Young adult C57BL/6N male mice were exposed to sevoflurane, with or without concomitant lipopolysaccharide injection. Sevoflurane was chosen for anaesthesia as it is widely used in clinical practice and lipopolysaccharide was chosen to mimic surgically induced systemic inflammation in order to avoid postoperative pain associated motor impairment that might interference with motor based cognitive testing. The results show that sevoflurane anaesthesia at clinically relevant concentrations is associated with short-term impairment of working memory and changes in synaptic function in the enriched synaptosomal fraction of the frontal cortex. There was an additive effect of the two treatments on systemic inflammation and neuroinflammation but these were not translated into significant changes in cognitive and synaptic function. Overall, there was a lack of strong evidence to support an important contribution of sevoflurane towards the development of POCD using this animal model.
DegreeMaster of Philosophy
SubjectAnesthetics - Complications
Dept/ProgramAnaesthesiology
Persistent Identifierhttp://hdl.handle.net/10722/240666
HKU Library Item IDb5855002

 

DC FieldValueLanguage
dc.contributor.authorLeung, Wing-yan, Yonna-
dc.contributor.author梁詠恩-
dc.date.accessioned2017-05-09T23:14:53Z-
dc.date.available2017-05-09T23:14:53Z-
dc.date.issued2016-
dc.identifier.citationLeung, W. Y. [梁詠恩]. (2016). The effect of sevoflurane on cognitive and synaptic function. (Thesis). University of Hong Kong, Pokfulam, Hong Kong SAR.-
dc.identifier.urihttp://hdl.handle.net/10722/240666-
dc.description.abstractAdvances in surgical and anaesthetic care have improved long term survival after surgery but in doing so have uncovered incidentally the phenomenon of postoperative cognitive dysfunction (POCD). The mechanisms underlying the development of POCD is still not fully elucidated but is currently thought to involve systemic inflammation induced surgical trauma, leading to neuroinflammation. As surgery almost always requires to be performed under anaesthesia, it is of great interest to evaluate any effects and/or interaction, if any, between anaesthesia and surgically induced systemic inflammation has on cognitive and synaptic function. This in turn might provide insights into the development and progression of POCD. Young adult C57BL/6N male mice were exposed to sevoflurane, with or without concomitant lipopolysaccharide injection. Sevoflurane was chosen for anaesthesia as it is widely used in clinical practice and lipopolysaccharide was chosen to mimic surgically induced systemic inflammation in order to avoid postoperative pain associated motor impairment that might interference with motor based cognitive testing. The results show that sevoflurane anaesthesia at clinically relevant concentrations is associated with short-term impairment of working memory and changes in synaptic function in the enriched synaptosomal fraction of the frontal cortex. There was an additive effect of the two treatments on systemic inflammation and neuroinflammation but these were not translated into significant changes in cognitive and synaptic function. Overall, there was a lack of strong evidence to support an important contribution of sevoflurane towards the development of POCD using this animal model.-
dc.languageeng-
dc.publisherThe University of Hong Kong (Pokfulam, Hong Kong)-
dc.relation.ispartofHKU Theses Online (HKUTO)-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.rightsThe author retains all proprietary rights, (such as patent rights) and the right to use in future works.-
dc.subject.lcshAnesthetics - Complications-
dc.titleThe effect of sevoflurane on cognitive and synaptic function-
dc.typePG_Thesis-
dc.identifier.hkulb5855002-
dc.description.thesisnameMaster of Philosophy-
dc.description.thesislevelMaster-
dc.description.thesisdisciplineAnaesthesiology-
dc.description.naturepublished_or_final_version-

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