File Download
  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Sensitivity of diffusion MRI to perilesional reactive astrogliosis in focal ischemia

TitleSensitivity of diffusion MRI to perilesional reactive astrogliosis in focal ischemia
Authors
Issue Date2017
PublisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291099-1492
Citation
NMR in Biomedicine, 2017, v. 30 n. 7, p. e3717:1-8 How to Cite?
AbstractReactive astrogliosis is a response to injury in the central nervous system that plays an essential role in inflammation and tissue repair. It is characterized by hypertrophy of astrocytes, alterations in astrocyte gene expression and astrocyte proliferation. Reactive astrogliosis occurs in multiple neuropathologies, including stroke, traumatic brain injury and Alzheimer's disease, and it has been proposed as a possible source of the changes in diffusion magnetic resonance imaging (dMRI) metrics observed with these diseases. In this study, the sensitivity of dMRI to reactive astrogliosis was tested in an animal model of focal acute and subacute ischemia induced by the vasoconstricting peptide, endothelin-1. Reactive astrogliosis in perilesional cortex was quantified by calculating the astrocyte surface density as determined with a glial fibrillary acidic protein (GFAP) antibody, whereas perilesional diffusion changes were measured in vivo with diffusional kurtosis imaging. We found substantial changes in the surface density of GFAP-positive astrocyte processes and modest changes in dMRI metrics in the perilesional motor cortex following stroke. Although there are time point-specific correlations between dMRI and histological measures, there is no definitive evidence for a causal relationship.
Persistent Identifierhttp://hdl.handle.net/10722/239543
ISSN
2017 Impact Factor: 3.031
2015 SCImago Journal Rankings: 1.533
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWeber, RA-
dc.contributor.authorChan, CH-
dc.contributor.authorNie, X-
dc.contributor.authorMaggioncalda, E-
dc.contributor.authorValiulis, G-
dc.contributor.authorLauer, A-
dc.contributor.authorHui, SK-
dc.contributor.authorJensen, JH-
dc.contributor.authorAdkins, DL-
dc.date.accessioned2017-03-21T09:15:35Z-
dc.date.available2017-03-21T09:15:35Z-
dc.date.issued2017-
dc.identifier.citationNMR in Biomedicine, 2017, v. 30 n. 7, p. e3717:1-8-
dc.identifier.issn0952-3480-
dc.identifier.urihttp://hdl.handle.net/10722/239543-
dc.description.abstractReactive astrogliosis is a response to injury in the central nervous system that plays an essential role in inflammation and tissue repair. It is characterized by hypertrophy of astrocytes, alterations in astrocyte gene expression and astrocyte proliferation. Reactive astrogliosis occurs in multiple neuropathologies, including stroke, traumatic brain injury and Alzheimer's disease, and it has been proposed as a possible source of the changes in diffusion magnetic resonance imaging (dMRI) metrics observed with these diseases. In this study, the sensitivity of dMRI to reactive astrogliosis was tested in an animal model of focal acute and subacute ischemia induced by the vasoconstricting peptide, endothelin-1. Reactive astrogliosis in perilesional cortex was quantified by calculating the astrocyte surface density as determined with a glial fibrillary acidic protein (GFAP) antibody, whereas perilesional diffusion changes were measured in vivo with diffusional kurtosis imaging. We found substantial changes in the surface density of GFAP-positive astrocyte processes and modest changes in dMRI metrics in the perilesional motor cortex following stroke. Although there are time point-specific correlations between dMRI and histological measures, there is no definitive evidence for a causal relationship.-
dc.languageeng-
dc.publisherJohn Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291099-1492-
dc.relation.ispartofNMR in Biomedicine-
dc.rightsNMR in Biomedicine. Copyright © John Wiley & Sons Ltd.-
dc.rightsThis is the peer reviewed version of the following article: NMR in Biomedicine, 2017, v. 30 n. 7, p. e3717:1-8, which has been published in final form at https://doi.org/10.1002/nbm.3717. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.-
dc.titleSensitivity of diffusion MRI to perilesional reactive astrogliosis in focal ischemia-
dc.typeArticle-
dc.identifier.emailHui, SK: edshui@hku.hk-
dc.identifier.authorityHui, SK=rp01832-
dc.description.naturepostprint-
dc.identifier.doi10.1002/nbm.3717-
dc.identifier.hkuros271669-
dc.identifier.volume30-
dc.identifier.issue7-
dc.identifier.spagee3717-
dc.identifier.epagee3717-
dc.identifier.isiWOS:000405325100006-
dc.publisher.placeUnited Kingdom-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats