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Article: Sensitivity of diffusion MRI to perilesional reactive astrogliosis in focal ischemia
Title | Sensitivity of diffusion MRI to perilesional reactive astrogliosis in focal ischemia |
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Authors | |
Keywords | astrogliosis diffusion GFAP imaging ischemia MRI perilesional stereology |
Issue Date | 2017 |
Publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291099-1492 |
Citation | NMR in Biomedicine, 2017, v. 30 n. 7, p. e3717:1-8 How to Cite? |
Abstract | Reactive astrogliosis is a response to injury in the central nervous system that plays an essential role in inflammation and tissue repair. It is characterized by hypertrophy of astrocytes, alterations in astrocyte gene expression and astrocyte proliferation. Reactive astrogliosis occurs in multiple neuropathologies, including stroke, traumatic brain injury and Alzheimer's disease, and it has been proposed as a possible source of the changes in diffusion magnetic resonance imaging (dMRI) metrics observed with these diseases. In this study, the sensitivity of dMRI to reactive astrogliosis was tested in an animal model of focal acute and subacute ischemia induced by the vasoconstricting peptide, endothelin-1. Reactive astrogliosis in perilesional cortex was quantified by calculating the astrocyte surface density as determined with a glial fibrillary acidic protein (GFAP) antibody, whereas perilesional diffusion changes were measured in vivo with diffusional kurtosis imaging. We found substantial changes in the surface density of GFAP-positive astrocyte processes and modest changes in dMRI metrics in the perilesional motor cortex following stroke. Although there are time point-specific correlations between dMRI and histological measures, there is no definitive evidence for a causal relationship. |
Persistent Identifier | http://hdl.handle.net/10722/239543 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 0.949 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Weber, RA | - |
dc.contributor.author | Chan, CH | - |
dc.contributor.author | Nie, X | - |
dc.contributor.author | Maggioncalda, E | - |
dc.contributor.author | Valiulis, G | - |
dc.contributor.author | Lauer, A | - |
dc.contributor.author | Hui, SK | - |
dc.contributor.author | Jensen, JH | - |
dc.contributor.author | Adkins, DL | - |
dc.date.accessioned | 2017-03-21T09:15:35Z | - |
dc.date.available | 2017-03-21T09:15:35Z | - |
dc.date.issued | 2017 | - |
dc.identifier.citation | NMR in Biomedicine, 2017, v. 30 n. 7, p. e3717:1-8 | - |
dc.identifier.issn | 0952-3480 | - |
dc.identifier.uri | http://hdl.handle.net/10722/239543 | - |
dc.description.abstract | Reactive astrogliosis is a response to injury in the central nervous system that plays an essential role in inflammation and tissue repair. It is characterized by hypertrophy of astrocytes, alterations in astrocyte gene expression and astrocyte proliferation. Reactive astrogliosis occurs in multiple neuropathologies, including stroke, traumatic brain injury and Alzheimer's disease, and it has been proposed as a possible source of the changes in diffusion magnetic resonance imaging (dMRI) metrics observed with these diseases. In this study, the sensitivity of dMRI to reactive astrogliosis was tested in an animal model of focal acute and subacute ischemia induced by the vasoconstricting peptide, endothelin-1. Reactive astrogliosis in perilesional cortex was quantified by calculating the astrocyte surface density as determined with a glial fibrillary acidic protein (GFAP) antibody, whereas perilesional diffusion changes were measured in vivo with diffusional kurtosis imaging. We found substantial changes in the surface density of GFAP-positive astrocyte processes and modest changes in dMRI metrics in the perilesional motor cortex following stroke. Although there are time point-specific correlations between dMRI and histological measures, there is no definitive evidence for a causal relationship. | - |
dc.language | eng | - |
dc.publisher | John Wiley & Sons Ltd. The Journal's web site is located at http://onlinelibrary.wiley.com/journal/10.1002/%28ISSN%291099-1492 | - |
dc.relation.ispartof | NMR in Biomedicine | - |
dc.rights | NMR in Biomedicine. Copyright © John Wiley & Sons Ltd. | - |
dc.rights | This is the peer reviewed version of the following article: NMR in Biomedicine, 2017, v. 30 n. 7, p. e3717:1-8, which has been published in final form at https://doi.org/10.1002/nbm.3717. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving. | - |
dc.subject | astrogliosis | - |
dc.subject | diffusion | - |
dc.subject | GFAP | - |
dc.subject | imaging | - |
dc.subject | ischemia | - |
dc.subject | MRI | - |
dc.subject | perilesional | - |
dc.subject | stereology | - |
dc.title | Sensitivity of diffusion MRI to perilesional reactive astrogliosis in focal ischemia | - |
dc.type | Article | - |
dc.identifier.email | Hui, SK: edshui@hku.hk | - |
dc.identifier.authority | Hui, SK=rp01832 | - |
dc.description.nature | postprint | - |
dc.identifier.doi | 10.1002/nbm.3717 | - |
dc.identifier.scopus | eid_2-s2.0-85014652613 | - |
dc.identifier.hkuros | 271669 | - |
dc.identifier.volume | 30 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | e3717 | - |
dc.identifier.epage | e3717 | - |
dc.identifier.isi | WOS:000405325100006 | - |
dc.publisher.place | United Kingdom | - |
dc.identifier.issnl | 0952-3480 | - |