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- Publisher Website: 10.1021/acs.nanolett.6b01730
- Scopus: eid_2-s2.0-84978708876
- WOS: WOS:000379794200079
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Article: Enhanced precision of nanoparticle phototargeting in vivo at a safe irradiance
Title | Enhanced precision of nanoparticle phototargeting in vivo at a safe irradiance |
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Authors | |
Keywords | phototargeted nanoparticles photoresponsive binding photon upconversion photocleavage Caged ligands |
Issue Date | 2016 |
Citation | Nano Letters, 2016, v. 16, n. 7, p. 4516-4520 How to Cite? |
Abstract | © 2016 American Chemical Society.A large proportion of the payload delivered by nanoparticulate therapies is deposited not in the desired target destination but in off-target locations such as the liver and spleen. Here, we demonstrate that phototargeting can improve the specific targeting of nanoparticles to tumors. The combination of efficient triplet-triplet annihilation upconversion (TTA-UC) and Förster resonance energy transfer (FRET) processes allowed in vivo phototargeting at a safe irradiance (200 mW/cm2) over a short period (5 min) using green light. |
Persistent Identifier | http://hdl.handle.net/10722/236727 |
ISSN | 2023 Impact Factor: 9.6 2023 SCImago Journal Rankings: 3.411 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Liu, Qian | - |
dc.contributor.author | Wang, Weiping | - |
dc.contributor.author | Zhan, Changyou | - |
dc.contributor.author | Yang, Tianshe | - |
dc.contributor.author | Kohane, Daniel S. | - |
dc.date.accessioned | 2016-12-02T03:07:29Z | - |
dc.date.available | 2016-12-02T03:07:29Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | Nano Letters, 2016, v. 16, n. 7, p. 4516-4520 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.uri | http://hdl.handle.net/10722/236727 | - |
dc.description.abstract | © 2016 American Chemical Society.A large proportion of the payload delivered by nanoparticulate therapies is deposited not in the desired target destination but in off-target locations such as the liver and spleen. Here, we demonstrate that phototargeting can improve the specific targeting of nanoparticles to tumors. The combination of efficient triplet-triplet annihilation upconversion (TTA-UC) and Förster resonance energy transfer (FRET) processes allowed in vivo phototargeting at a safe irradiance (200 mW/cm2) over a short period (5 min) using green light. | - |
dc.language | eng | - |
dc.relation.ispartof | Nano Letters | - |
dc.subject | phototargeted nanoparticles | - |
dc.subject | photoresponsive binding | - |
dc.subject | photon upconversion | - |
dc.subject | photocleavage | - |
dc.subject | Caged ligands | - |
dc.title | Enhanced precision of nanoparticle phototargeting in vivo at a safe irradiance | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/acs.nanolett.6b01730 | - |
dc.identifier.scopus | eid_2-s2.0-84978708876 | - |
dc.identifier.volume | 16 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 4516 | - |
dc.identifier.epage | 4520 | - |
dc.identifier.eissn | 1530-6992 | - |
dc.identifier.isi | WOS:000379794200079 | - |
dc.identifier.issnl | 1530-6984 | - |