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- Publisher Website: 10.1021/nl403733z
- Scopus: eid_2-s2.0-84903975574
- PMID: 24884872
- WOS: WOS:000338979700001
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Article: Photothermally targeted thermosensitive polymer-masked nanoparticles
Title | Photothermally targeted thermosensitive polymer-masked nanoparticles |
---|---|
Authors | |
Keywords | temperature-responsive YIGSR pNIPAAm Au nanoshells phototargeting shielding |
Issue Date | 2014 |
Citation | Nano Letters, 2014, v. 14, n. 7, p. 3697-3701 How to Cite? |
Abstract | The targeted delivery of therapeutic cargos using noninvasive stimuli has the potential to improve efficacy and reduce off-target effects (toxicity). Here, we demonstrate a targeting mechanism that uses a thermoresponsive copolymer to mask a peptide ligand that binds a widely distributed receptor (integrin β1) on the surface of silica core-gold shell nanoparticles. The nanoparticles convert NIR light into heat, which causes the copolymer to collapse, exposing the ligand peptide, allowing cell binding. The use of NIR light could allow targeting of plasmonic nanoparticles deep within tissues. This approach could be extended to a variety of applications including photothermal therapy and drug delivery. © 2014 American Chemical Society. |
Persistent Identifier | http://hdl.handle.net/10722/236722 |
ISSN | 2023 Impact Factor: 9.6 2023 SCImago Journal Rankings: 3.411 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Barhoumi, Aoune | - |
dc.contributor.author | Wang, Weiping | - |
dc.contributor.author | Zurakowski, David | - |
dc.contributor.author | Langer, Robert S. | - |
dc.contributor.author | Kohane, Daniel S. | - |
dc.date.accessioned | 2016-12-02T03:07:29Z | - |
dc.date.available | 2016-12-02T03:07:29Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Nano Letters, 2014, v. 14, n. 7, p. 3697-3701 | - |
dc.identifier.issn | 1530-6984 | - |
dc.identifier.uri | http://hdl.handle.net/10722/236722 | - |
dc.description.abstract | The targeted delivery of therapeutic cargos using noninvasive stimuli has the potential to improve efficacy and reduce off-target effects (toxicity). Here, we demonstrate a targeting mechanism that uses a thermoresponsive copolymer to mask a peptide ligand that binds a widely distributed receptor (integrin β1) on the surface of silica core-gold shell nanoparticles. The nanoparticles convert NIR light into heat, which causes the copolymer to collapse, exposing the ligand peptide, allowing cell binding. The use of NIR light could allow targeting of plasmonic nanoparticles deep within tissues. This approach could be extended to a variety of applications including photothermal therapy and drug delivery. © 2014 American Chemical Society. | - |
dc.language | eng | - |
dc.relation.ispartof | Nano Letters | - |
dc.subject | temperature-responsive | - |
dc.subject | YIGSR | - |
dc.subject | pNIPAAm | - |
dc.subject | Au nanoshells | - |
dc.subject | phototargeting | - |
dc.subject | shielding | - |
dc.title | Photothermally targeted thermosensitive polymer-masked nanoparticles | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1021/nl403733z | - |
dc.identifier.pmid | 24884872 | - |
dc.identifier.scopus | eid_2-s2.0-84903975574 | - |
dc.identifier.volume | 14 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 3697 | - |
dc.identifier.epage | 3701 | - |
dc.identifier.eissn | 1530-6992 | - |
dc.identifier.isi | WOS:000338979700001 | - |
dc.identifier.issnl | 1530-6984 | - |