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Article: Comparative study of biphasic calcium phosphates with different HA/TCP ratios in mandibular bone defects. A long-term histomorphometric study in minipigs

TitleComparative study of biphasic calcium phosphates with different HA/TCP ratios in mandibular bone defects. A long-term histomorphometric study in minipigs
Authors
KeywordsBone graft
Deproteinized bovine bone mineral
Calcium phosphate
Bone substitute
Bone regeneration
Issue Date2009
Citation
Journal of Biomedical Materials Research - Part B Applied Biomaterials, 2009, v. 90 B, n. 1, p. 171-181 How to Cite?
AbstractThree biphasic calcium phosphate (BCP) bone substitute materials with hydroxyapatite (HA)/tricalcium phosphate (TCP) ratios of 20/80, 60/40, and 80/20 were compared to coagulum, particulated autogenous bone, and deproteinized bovine bone mineral (DBBM) in membrane-protected bone defects. The defects were prepared in the mandibles of 24 minipigs that were divided into four groups of six with healing times of 4, 13, 26, and 52 weeks, respectively. The histologic and histomorphometric evaluation focused on differences in amount and pattern of bone formation, filler degradation, and the interface between bone and filler. Collapse of the expanded polytetrafluoroethylene barrier membrane into the coagulum defects underlined the necessity of a filler material to maintain the augmented volume. Quantitatively, BCP 20/80 showed bone formation and degradation of the filler material similar to autografts, whereas BCP 60/40 and BCP 80/20 rather equaled DBBM. Among the three BCP's, the amount of bone formation and degradation of filler material seemed to be inversely proportional to the HA/TCP ratio. The fraction of filler surface covered with bone was highest for autografts at all time points and was higher for DBBM than BCP 80/ 20 and 60/40 at the early healing phase. TRAP-positive multinucleated cells were identified on BCP and DBBM surfaces without showing typical signs of resorption lacunae. © 2008 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/236146
ISSN
2017 Impact Factor: 3.373
2015 SCImago Journal Rankings: 0.784
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJensen, Simon Storgård-
dc.contributor.authorBornstein, Michael M.-
dc.contributor.authorDard, Michel-
dc.contributor.authorBosshardt, Dieter D.-
dc.contributor.authorBuser, Daniel-
dc.date.accessioned2016-11-11T07:43:03Z-
dc.date.available2016-11-11T07:43:03Z-
dc.date.issued2009-
dc.identifier.citationJournal of Biomedical Materials Research - Part B Applied Biomaterials, 2009, v. 90 B, n. 1, p. 171-181-
dc.identifier.issn1552-4973-
dc.identifier.urihttp://hdl.handle.net/10722/236146-
dc.description.abstractThree biphasic calcium phosphate (BCP) bone substitute materials with hydroxyapatite (HA)/tricalcium phosphate (TCP) ratios of 20/80, 60/40, and 80/20 were compared to coagulum, particulated autogenous bone, and deproteinized bovine bone mineral (DBBM) in membrane-protected bone defects. The defects were prepared in the mandibles of 24 minipigs that were divided into four groups of six with healing times of 4, 13, 26, and 52 weeks, respectively. The histologic and histomorphometric evaluation focused on differences in amount and pattern of bone formation, filler degradation, and the interface between bone and filler. Collapse of the expanded polytetrafluoroethylene barrier membrane into the coagulum defects underlined the necessity of a filler material to maintain the augmented volume. Quantitatively, BCP 20/80 showed bone formation and degradation of the filler material similar to autografts, whereas BCP 60/40 and BCP 80/20 rather equaled DBBM. Among the three BCP's, the amount of bone formation and degradation of filler material seemed to be inversely proportional to the HA/TCP ratio. The fraction of filler surface covered with bone was highest for autografts at all time points and was higher for DBBM than BCP 80/ 20 and 60/40 at the early healing phase. TRAP-positive multinucleated cells were identified on BCP and DBBM surfaces without showing typical signs of resorption lacunae. © 2008 Wiley Periodicals, Inc.-
dc.languageeng-
dc.relation.ispartofJournal of Biomedical Materials Research - Part B Applied Biomaterials-
dc.subjectBone graft-
dc.subjectDeproteinized bovine bone mineral-
dc.subjectCalcium phosphate-
dc.subjectBone substitute-
dc.subjectBone regeneration-
dc.titleComparative study of biphasic calcium phosphates with different HA/TCP ratios in mandibular bone defects. A long-term histomorphometric study in minipigs-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1002/jbm.b.31271-
dc.identifier.pmid19085941-
dc.identifier.scopuseid_2-s2.0-67650818948-
dc.identifier.volume90 B-
dc.identifier.issue1-
dc.identifier.spage171-
dc.identifier.epage181-
dc.identifier.eissn1552-4981-
dc.identifier.isiWOS:000267298500021-

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