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Article: Pharmacological Actions of Glucagon-Like Peptide-1, Gastric Inhibitory Polypeptide, and Glucagon

TitlePharmacological Actions of Glucagon-Like Peptide-1, Gastric Inhibitory Polypeptide, and Glucagon
Authors
Issue Date2016
Citation
International review of cell and molecular biology, 2016 How to Cite?
AbstractGlucagon family of peptide hormones is a group of structurally related brain-gut peptides that exert their pleiotropic actions through interactions with unique members of class B1 G protein–coupled receptors (GPCRs). They are key regulators of hormonal homeostasis and are important drug targets for metabolic disorders such as type-2 diabetes mellitus (T2DM), obesity, and dysregulations of the nervous systems such as migraine, anxiety, depression, neurodegeneration, psychiatric disorders, and cardiovascular diseases. The current review aims to provide a detailed overview of the current understanding of the pharmacological actions and therapeutic advances of three members within this family including glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), and glucagon.
Persistent Identifierhttp://hdl.handle.net/10722/235369

 

DC FieldValueLanguage
dc.contributor.authorSekar, R-
dc.contributor.authorSINGH, K-
dc.contributor.authorAROKIARAJ, AWR-
dc.contributor.authorChow, BKC-
dc.date.accessioned2016-10-14T13:52:51Z-
dc.date.available2016-10-14T13:52:51Z-
dc.date.issued2016-
dc.identifier.citationInternational review of cell and molecular biology, 2016-
dc.identifier.urihttp://hdl.handle.net/10722/235369-
dc.description.abstractGlucagon family of peptide hormones is a group of structurally related brain-gut peptides that exert their pleiotropic actions through interactions with unique members of class B1 G protein–coupled receptors (GPCRs). They are key regulators of hormonal homeostasis and are important drug targets for metabolic disorders such as type-2 diabetes mellitus (T2DM), obesity, and dysregulations of the nervous systems such as migraine, anxiety, depression, neurodegeneration, psychiatric disorders, and cardiovascular diseases. The current review aims to provide a detailed overview of the current understanding of the pharmacological actions and therapeutic advances of three members within this family including glucagon-like peptide-1 (GLP-1), gastric inhibitory polypeptide (GIP), and glucagon.-
dc.languageeng-
dc.relation.ispartofInternational review of cell and molecular biology-
dc.titlePharmacological Actions of Glucagon-Like Peptide-1, Gastric Inhibitory Polypeptide, and Glucagon-
dc.typeArticle-
dc.identifier.emailSekar, R: revathis@hku.hk-
dc.identifier.emailChow, BKC: bkcc@hku.hk-
dc.identifier.authorityChow, BKC=rp00681-
dc.identifier.doi10.1016/bs.ircmb.2016.05.002-
dc.identifier.hkuros270150-

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