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Article: All-Aqueous Electrosprayed Emulsion for Templated Fabrication of Cytocompatible Microcapsules

TitleAll-Aqueous Electrosprayed Emulsion for Templated Fabrication of Cytocompatible Microcapsules
Authors
KeywordsAll-aqueous droplets
Biomolecular assembly
Cell encapsulation
Core-shell microcapsules
Electrospray
w/w/w double emulsion
Issue Date2015
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/aamick
Citation
ACS Applied Materials & Interfaces, 2015, v. 7 n. 25, p. 13925-13933 How to Cite?
AbstractEncapsulation of biomolecules and cells in hydrogel capsules via emulsion templating frequently induces an irreversible loss of bioactivity, because of the use of nonaqueous solvents. Here, we introduce an all-aqueous electrospray (AAE) approach to generate aqueous two-phase emulsion droplets, and we use them as templates to fabricate microcapsules with preserved cell viability. The approach allows formation of monodisperse microparticles with tunable sizes, variable compositions, and interior architectures in a mild gelation process. This technique potentially benefits a variety of new biomedical applications, such as delivery of bioactive proteins, transplantation of living cells, and assembly of cell-mimicking structures. (Figure Presented).
Persistent Identifierhttp://hdl.handle.net/10722/234660
ISSN
2017 Impact Factor: 8.097
2015 SCImago Journal Rankings: 2.381
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorSong, Y-
dc.contributor.authorChan, YK-
dc.contributor.authorMa, Q-
dc.contributor.authorLiu, Z-
dc.contributor.authorShum, HC-
dc.date.accessioned2016-10-14T13:48:20Z-
dc.date.available2016-10-14T13:48:20Z-
dc.date.issued2015-
dc.identifier.citationACS Applied Materials & Interfaces, 2015, v. 7 n. 25, p. 13925-13933-
dc.identifier.issn1944-8244-
dc.identifier.urihttp://hdl.handle.net/10722/234660-
dc.description.abstractEncapsulation of biomolecules and cells in hydrogel capsules via emulsion templating frequently induces an irreversible loss of bioactivity, because of the use of nonaqueous solvents. Here, we introduce an all-aqueous electrospray (AAE) approach to generate aqueous two-phase emulsion droplets, and we use them as templates to fabricate microcapsules with preserved cell viability. The approach allows formation of monodisperse microparticles with tunable sizes, variable compositions, and interior architectures in a mild gelation process. This technique potentially benefits a variety of new biomedical applications, such as delivery of bioactive proteins, transplantation of living cells, and assembly of cell-mimicking structures. (Figure Presented).-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/journal/aamick-
dc.relation.ispartofACS Applied Materials & Interfaces-
dc.subjectAll-aqueous droplets-
dc.subjectBiomolecular assembly-
dc.subjectCell encapsulation-
dc.subjectCore-shell microcapsules-
dc.subjectElectrospray-
dc.subjectw/w/w double emulsion-
dc.titleAll-Aqueous Electrosprayed Emulsion for Templated Fabrication of Cytocompatible Microcapsules-
dc.typeArticle-
dc.identifier.emailChan, YK: josephyk@connect.hku.hk-
dc.identifier.emailLiu, Z: zliu89@hku.hk-
dc.identifier.emailShum, HC: ashum@hku.hk-
dc.identifier.authorityChan, YK=rp02536-
dc.identifier.authorityShum, HC=rp01439-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/acsami.5b02708-
dc.identifier.pmid26053733-
dc.identifier.scopuseid_2-s2.0-84934780079-
dc.identifier.hkuros268358-
dc.identifier.volume7-
dc.identifier.issue25-
dc.identifier.spage13925-
dc.identifier.epage13933-
dc.identifier.isiWOS:000357436800024-
dc.publisher.placeUnited States-

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