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Book Chapter: Gene Delivery for the Generation of Bioartificial Pacemaker

TitleGene Delivery for the Generation of Bioartificial Pacemaker
Authors
Issue Date2016
Citation
Gene Delivery for the Generation of Bioartificial Pacemaker. In Kiyotake Ishikawa (Eds.), Cardiac Gene Therapy (Methods in Molecular Biology), v. 1521.  How to Cite?
AbstractElectronic pacemakers have been used in patients with heart rhythm disorders for device-supported pacing. While effective, there are such shortcomings as limited battery life, permanent implantation of catheters, the lack of autonomic neurohumoral responses, and risks of lead dislodging. Here we describe protocols for establishing porcine models of sick sinus syndrome and complete heart block, and the generation of bioartificial pacemaker by delivering a strategically engineered form of hyperpolarization-activated cyclic nucleotide-gated pacemaker channel protein via somatic gene transfer to convert atrial or ventricular muscle cardiomyocytes into nodal-like cells that rhythmically fire action potentials.
Persistent Identifierhttp://hdl.handle.net/10722/234403
ISBN

 

DC FieldValueLanguage
dc.contributor.authorChan, KWP-
dc.contributor.authorLi, RA-
dc.date.accessioned2016-10-14T13:46:39Z-
dc.date.available2016-10-14T13:46:39Z-
dc.date.issued2016-
dc.identifier.citationGene Delivery for the Generation of Bioartificial Pacemaker. In Kiyotake Ishikawa (Eds.), Cardiac Gene Therapy (Methods in Molecular Biology), v. 1521. -
dc.identifier.isbn9781493965861-
dc.identifier.urihttp://hdl.handle.net/10722/234403-
dc.description.abstractElectronic pacemakers have been used in patients with heart rhythm disorders for device-supported pacing. While effective, there are such shortcomings as limited battery life, permanent implantation of catheters, the lack of autonomic neurohumoral responses, and risks of lead dislodging. Here we describe protocols for establishing porcine models of sick sinus syndrome and complete heart block, and the generation of bioartificial pacemaker by delivering a strategically engineered form of hyperpolarization-activated cyclic nucleotide-gated pacemaker channel protein via somatic gene transfer to convert atrial or ventricular muscle cardiomyocytes into nodal-like cells that rhythmically fire action potentials.-
dc.languageeng-
dc.relation.ispartofCardiac Gene Therapy (Methods in Molecular Biology)-
dc.titleGene Delivery for the Generation of Bioartificial Pacemaker-
dc.typeBook_Chapter-
dc.identifier.emailChan, KWP: pazhi@hku.hk-
dc.identifier.emailLi, RA: ronaldli@hkucc.hku.hk-
dc.identifier.authorityLi, RA=rp01352-
dc.identifier.doi10.1007/978-1-4939-6588-5_21-
dc.identifier.hkuros268215-
dc.identifier.volume1521-

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