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Article: The Clinicopathological Significance of miR-133a in Colorectal Cancer

TitleThe Clinicopathological Significance of miR-133a in Colorectal Cancer
Authors
Issue Date2014
Citation
Disease Markers, 2014, v. 2014 How to Cite?
AbstractThis study determined the expression of microRNA-133a (MiR-133a) in colorectal cancer (CRC) and adjacent normal mucosa samples and evaluated its clinicopathological role in CRC. The expression of miR-133a in 125 pairs of tissue samples was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) and correlated with patient's clinicopathological data by statistical analysis. Endogenous expression levels of several potential target genes were determined by qRT-PCR and correlated using Pearson's method. MiR-133a was downregulated in 83.2% of tumors compared to normal mucosal tissue. Higher miR-133a expression in tumor tissues was associated with development of distant metastasis, advanced Dukes and TNM staging, and poor survival. The unfavorable prognosis of higher miR-133a expression was accompanied by dysregulation of potential miR-133a target genes, LIM and SH3 domain protein 1 (LASP1), Caveolin-1 (CAV1), and Fascin-1 (FSCN1). LASP1 was found to possess a negative correlation (γ=-0.23), whereas CAV1 exhibited a significant positive correlation (γ=0.27), and a stronger correlation was found in patients who developed distant metastases (γ=0.42). In addition, a negative correlation of FSCN1 was only found in nonmetastatic patients. In conclusion, miR-133a was downregulated in CRC tissues, but its higher expression correlated with adverse clinical characteristics and poor prognosis. © 2014 Timothy Ming-Hun Wan et al.
Persistent Identifierhttp://hdl.handle.net/10722/233737
ISSN
2015 Impact Factor: 2.137
2015 SCImago Journal Rankings: 0.774

 

DC FieldValueLanguage
dc.contributor.authorWan, Timothy Ming Hun-
dc.contributor.authorLam, Colin Siu Chi-
dc.contributor.authorNg, Lui-
dc.contributor.authorChow, Ariel Ka Man-
dc.contributor.authorWong, Sunny Kit Man-
dc.contributor.authorLi, Hung Sing-
dc.contributor.authorMan, Johnny Hon Wai-
dc.contributor.authorLo, Oswens Siu Hung-
dc.contributor.authorFoo, Dominic-
dc.contributor.authorCheung, Alvin-
dc.contributor.authorYau, Thomas-
dc.contributor.authorPoon, Jensen Tung Chung-
dc.contributor.authorPoon, Ronnie Tung Ping-
dc.contributor.authorLaw, Wai Lun-
dc.contributor.authorPang, Roberta Wen Chi-
dc.date.accessioned2016-09-27T07:21:30Z-
dc.date.available2016-09-27T07:21:30Z-
dc.date.issued2014-
dc.identifier.citationDisease Markers, 2014, v. 2014-
dc.identifier.issn0278-0240-
dc.identifier.urihttp://hdl.handle.net/10722/233737-
dc.description.abstractThis study determined the expression of microRNA-133a (MiR-133a) in colorectal cancer (CRC) and adjacent normal mucosa samples and evaluated its clinicopathological role in CRC. The expression of miR-133a in 125 pairs of tissue samples was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) and correlated with patient's clinicopathological data by statistical analysis. Endogenous expression levels of several potential target genes were determined by qRT-PCR and correlated using Pearson's method. MiR-133a was downregulated in 83.2% of tumors compared to normal mucosal tissue. Higher miR-133a expression in tumor tissues was associated with development of distant metastasis, advanced Dukes and TNM staging, and poor survival. The unfavorable prognosis of higher miR-133a expression was accompanied by dysregulation of potential miR-133a target genes, LIM and SH3 domain protein 1 (LASP1), Caveolin-1 (CAV1), and Fascin-1 (FSCN1). LASP1 was found to possess a negative correlation (γ=-0.23), whereas CAV1 exhibited a significant positive correlation (γ=0.27), and a stronger correlation was found in patients who developed distant metastases (γ=0.42). In addition, a negative correlation of FSCN1 was only found in nonmetastatic patients. In conclusion, miR-133a was downregulated in CRC tissues, but its higher expression correlated with adverse clinical characteristics and poor prognosis. © 2014 Timothy Ming-Hun Wan et al.-
dc.languageeng-
dc.relation.ispartofDisease Markers-
dc.titleThe Clinicopathological Significance of miR-133a in Colorectal Cancer-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1155/2014/919283-
dc.identifier.pmid25104873-
dc.identifier.scopuseid_2-s2.0-84904647875-
dc.identifier.volume2014-
dc.identifier.spagenull-
dc.identifier.epagenull-
dc.identifier.eissn1875-8630-

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