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Article: Influenza A virus shedding and infectivity in households

TitleInfluenza A virus shedding and infectivity in households
Authors
KeywordsInfluenza
Infectiousness
Public health
Isolation
Issue Date2015
PublisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/
Citation
Journal of Infectious Diseases, 2015, v. 212 n. 9, p. 1420-1428 How to Cite?
AbstractBackground. Viral shedding is often considered to correlate with the infectivity of influenza, but the evidence for this is limited. Methods. In a detailed study of influenza virus transmission within households in 2008–2012, index case patients with confirmed influenza were identified in outpatient clinics, and we collected nose and throat swab specimens for testing by reverse-transcription polymerase chain reaction from all household members regardless of illness. We used individual-based hazard models to characterize the relationship between viral load (V) and infectivity. Results. Assuming that infectivity was proportional to viral load V gave the worst fit, because it strongly overestimated the proportion of transmission occurring at symptom onset. Alternative models assuming that infectivity was proportional to a various functions of V provided better fits, although they all overestimated the proportion of transmission occurring >3 days after symptom onset. The best fitting model assumed that infectivity was proportion to Vγ, with estimates of γ = 0.136 and γ = 0.156 for seasonal influenza A(H1N1) and A(H3N2) respectively. Conclusions. All the models we considered that used viral loads to approximate infectivity of a case imperfectly explained the timing of influenza secondary infections in households. Identification of more accurate correlates of infectivity will be important to inform control policies and disease modeling.
Persistent Identifierhttp://hdl.handle.net/10722/233549
ISSN
2017 Impact Factor: 5.186
2015 SCImago Journal Rankings: 4.000
PubMed Central ID
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorTsang, TK-
dc.contributor.authorCowling, BJ-
dc.contributor.authorFang, VJ-
dc.contributor.authorChan, KH-
dc.contributor.authorIp, DKM-
dc.contributor.authorLeung, GM-
dc.contributor.authorPeiris, JSM-
dc.contributor.authorCauchemez, S-
dc.date.accessioned2016-09-20T05:37:32Z-
dc.date.available2016-09-20T05:37:32Z-
dc.date.issued2015-
dc.identifier.citationJournal of Infectious Diseases, 2015, v. 212 n. 9, p. 1420-1428-
dc.identifier.issn0022-1899-
dc.identifier.urihttp://hdl.handle.net/10722/233549-
dc.description.abstractBackground. Viral shedding is often considered to correlate with the infectivity of influenza, but the evidence for this is limited. Methods. In a detailed study of influenza virus transmission within households in 2008–2012, index case patients with confirmed influenza were identified in outpatient clinics, and we collected nose and throat swab specimens for testing by reverse-transcription polymerase chain reaction from all household members regardless of illness. We used individual-based hazard models to characterize the relationship between viral load (V) and infectivity. Results. Assuming that infectivity was proportional to viral load V gave the worst fit, because it strongly overestimated the proportion of transmission occurring at symptom onset. Alternative models assuming that infectivity was proportional to a various functions of V provided better fits, although they all overestimated the proportion of transmission occurring >3 days after symptom onset. The best fitting model assumed that infectivity was proportion to Vγ, with estimates of γ = 0.136 and γ = 0.156 for seasonal influenza A(H1N1) and A(H3N2) respectively. Conclusions. All the models we considered that used viral loads to approximate infectivity of a case imperfectly explained the timing of influenza secondary infections in households. Identification of more accurate correlates of infectivity will be important to inform control policies and disease modeling.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://www.oxfordjournals.org/our_journals/jid/-
dc.relation.ispartofJournal of Infectious Diseases-
dc.subjectInfluenza-
dc.subjectInfectiousness-
dc.subjectPublic health-
dc.subjectIsolation-
dc.titleInfluenza A virus shedding and infectivity in households-
dc.typeArticle-
dc.identifier.emailTsang, TK: matklab@hku.hk-
dc.identifier.emailCowling, BJ: bcowling@hku.hk-
dc.identifier.emailFang, VJ: vickyf@hku.hk-
dc.identifier.emailChan, KH: chankh2@hkucc.hku.hk-
dc.identifier.emailIp, DKM: dkmip@hku.hk-
dc.identifier.emailLeung, GM: gmleung@hku.hk-
dc.identifier.emailPeiris, JSM: malik@hkucc.hku.hk-
dc.identifier.authorityTsang, TK=rp02571-
dc.identifier.authorityCowling, BJ=rp01326-
dc.identifier.authorityChan, KH=rp01921-
dc.identifier.authorityIp, DKM=rp00256-
dc.identifier.authorityLeung, GM=rp00460-
dc.identifier.authorityPeiris, JSM=rp00410-
dc.description.naturelink_to_OA_fulltext-
dc.identifier.doi10.1093/infdis/jiv225-
dc.identifier.pmid25883385-
dc.identifier.pmcidPMC4601913-
dc.identifier.scopuseid_2-s2.0-84946109725-
dc.identifier.hkuros263954-
dc.identifier.volume212-
dc.identifier.issue9-
dc.identifier.spage1420-
dc.identifier.epage1428-
dc.identifier.isiWOS:000364767500011-
dc.publisher.placeUnited States-

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