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Article: Structural and Maturational Covariance in Early Childhood Brain Development

TitleStructural and Maturational Covariance in Early Childhood Brain Development
Authors
Issue Date2016
PublisherOxford University Press. The Journal's web site is located at http://cercor.oxfordjournals.org/
Citation
Cerebral Cortex, 2016 How to Cite?
AbstractBrain structural covariance networks (SCNs) composed of regions with correlated variation are altered in neuropsychiatric disease and change with age. Little is known about the development of SCNs in early childhood, a period of rapid cortical growth. We investigated the development of structural and maturational covariance networks, including default, dorsal attention, primary visual and sensorimotor networks in a longitudinal population of 118 children after birth to 2 years old and compared them with intrinsic functional connectivity networks. We found that structural covariance of all networks exhibit strong correlations mostly limited to their seed regions. By Age 2, default and dorsal attention structural networks are much less distributed compared with their functional maps. The maturational covariance maps, however, revealed significant couplings in rates of change between distributed regions, which partially recapitulate their functional networks. The structural and maturational covariance of the primary visual and sensorimotor networks shows similar patterns to the corresponding functional networks. Results indicate that functional networks are in place prior to structural networks, that correlated structural patterns in adult may arise in part from coordinated cortical maturation, and that regional co-activation in functional networks may guide and refine the maturation of SCNs over childhood development.
Persistent Identifierhttp://hdl.handle.net/10722/232973
ISSN
2015 Impact Factor: 8.285
2015 SCImago Journal Rankings: 4.827

 

DC FieldValueLanguage
dc.contributor.authorGeng, X-
dc.contributor.authorLi, G-
dc.contributor.authorLu, Z-
dc.contributor.authorGao, W-
dc.contributor.authorWang, L-
dc.contributor.authorShen, D-
dc.contributor.authorZhu, H-
dc.contributor.authorGilmore, JH-
dc.date.accessioned2016-09-20T05:33:43Z-
dc.date.available2016-09-20T05:33:43Z-
dc.date.issued2016-
dc.identifier.citationCerebral Cortex, 2016-
dc.identifier.issn1047-3211-
dc.identifier.urihttp://hdl.handle.net/10722/232973-
dc.description.abstractBrain structural covariance networks (SCNs) composed of regions with correlated variation are altered in neuropsychiatric disease and change with age. Little is known about the development of SCNs in early childhood, a period of rapid cortical growth. We investigated the development of structural and maturational covariance networks, including default, dorsal attention, primary visual and sensorimotor networks in a longitudinal population of 118 children after birth to 2 years old and compared them with intrinsic functional connectivity networks. We found that structural covariance of all networks exhibit strong correlations mostly limited to their seed regions. By Age 2, default and dorsal attention structural networks are much less distributed compared with their functional maps. The maturational covariance maps, however, revealed significant couplings in rates of change between distributed regions, which partially recapitulate their functional networks. The structural and maturational covariance of the primary visual and sensorimotor networks shows similar patterns to the corresponding functional networks. Results indicate that functional networks are in place prior to structural networks, that correlated structural patterns in adult may arise in part from coordinated cortical maturation, and that regional co-activation in functional networks may guide and refine the maturation of SCNs over childhood development.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://cercor.oxfordjournals.org/-
dc.relation.ispartofCerebral Cortex-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here]. -
dc.titleStructural and Maturational Covariance in Early Childhood Brain Development-
dc.typeArticle-
dc.identifier.emailGeng, X: gengx@HKUCC-COM.hku.hk-
dc.identifier.authorityGeng, X=rp01678-
dc.identifier.authorityLi, G=rp02224-
dc.identifier.authorityLu, Z=rp02224-
dc.identifier.authorityGao, W=rp02224-
dc.identifier.authorityWang, L=rp02224-
dc.identifier.authorityShen, D=rp02224-
dc.identifier.authorityZhu, H=rp02224-
dc.identifier.authorityGilmore, JH=rp02224-
dc.identifier.doi10.1093/cercor/bhw022-
dc.identifier.pmid26874184-
dc.identifier.hkuros266790-
dc.publisher.placeUnited Kingdom-

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