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Conference Paper: Combined major liver resection and radiofrequency ablation for multifocal hepatocellular carcinoma

TitleCombined major liver resection and radiofrequency ablation for multifocal hepatocellular carcinoma
Authors
Issue Date2016
PublisherS. Karger AG. The Journal's web site is located at http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&ProduktNr=255487
Citation
The 7th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2016), Hong Kong, China, 8-10 July 2016. In Liver Cancer, 2016, v. 5 suppl. 1, p. 50, abstract no. 0053 How to Cite?
AbstractBACKGROUND: Multifocal hepatocellular carcinoma (HCC) remained a difficult condition to be treated, as patients may be out of liver transplantation criteria, as well as inadequate liver remnant to undergo major hepatectomy. This study aimed to review the outcome of the patents undergoing combined resection and radiofrequency ablation (RFA). METHODS: From January 2001 to December 2013, the postoperative and oncological outcomes of all patients who had undergone major liver resection and RFA for multifocal HCC in Queen Mary Hospital, Hong Kong, were reviewed. The baseline characteristics was matched by propensity score matching in a ratio of 1:8. Survival analysis was performed by Kaplan Meier methods and compared between subgroup with log-rank test. Risk factors affecting survival were determined by Cox regression model. RESULTS: A total of 16 patients undergoing major liver resection and RFA for multifocal were matched with 128 patients undergoing major resection alone during the study period. There were no difference in terms of the baseline characteristics, comorbidities. Patients in both groups had similar Child Pugh grading and MELD score. In spite of the higher ICG retention rate at 15 minutes for the combined group, it was still within the normal range (12.7% vs. 10.6%, p = 0.026). Both groups of patients suffered from similar number of tumors, but only 47 patients (36.7%) were bilobar in the liver resection group. There were no difference in terms of the operative procedures, outcome and hospital stay, neither the pathology of the tumors. Despite the multifocality of the HCC and bilobar involvement, combined resection resulted in similar overall survival (5-year 24.1% vs. 40.1%, p = 0.164). Prolonged hospital stay and tumor with microvascular invasion were the risk factors for poorer overall survival. CONCLUSION: Aggressive management of HCC with combination modalities, such as liver resection and RFA, should always be considered for bilobar multifocal HCC.
DescriptionSession 18: Oral Presentation (Surgery and Radiology)
This journal suppl. entitled: The 7th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2016). Advancing HCC Management through Multi-Disciplinary Approach. Hong Kong, SAR (China), July 8-10, 2016: Abstracts
Persistent Identifierhttp://hdl.handle.net/10722/232586
ISSN

 

DC FieldValueLanguage
dc.contributor.authorShe, WH-
dc.contributor.authorCheung, TT-
dc.contributor.authorChan, ACY-
dc.contributor.authorChok, KSH-
dc.contributor.authorDai, WC-
dc.contributor.authorChan, SC-
dc.contributor.authorPoon, RTP-
dc.contributor.authorLo, CM-
dc.date.accessioned2016-09-20T05:31:03Z-
dc.date.available2016-09-20T05:31:03Z-
dc.date.issued2016-
dc.identifier.citationThe 7th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2016), Hong Kong, China, 8-10 July 2016. In Liver Cancer, 2016, v. 5 suppl. 1, p. 50, abstract no. 0053-
dc.identifier.issn2235-1795-
dc.identifier.urihttp://hdl.handle.net/10722/232586-
dc.descriptionSession 18: Oral Presentation (Surgery and Radiology)-
dc.descriptionThis journal suppl. entitled: The 7th Asia-Pacific Primary Liver Cancer Expert Meeting (APPLE 2016). Advancing HCC Management through Multi-Disciplinary Approach. Hong Kong, SAR (China), July 8-10, 2016: Abstracts-
dc.description.abstractBACKGROUND: Multifocal hepatocellular carcinoma (HCC) remained a difficult condition to be treated, as patients may be out of liver transplantation criteria, as well as inadequate liver remnant to undergo major hepatectomy. This study aimed to review the outcome of the patents undergoing combined resection and radiofrequency ablation (RFA). METHODS: From January 2001 to December 2013, the postoperative and oncological outcomes of all patients who had undergone major liver resection and RFA for multifocal HCC in Queen Mary Hospital, Hong Kong, were reviewed. The baseline characteristics was matched by propensity score matching in a ratio of 1:8. Survival analysis was performed by Kaplan Meier methods and compared between subgroup with log-rank test. Risk factors affecting survival were determined by Cox regression model. RESULTS: A total of 16 patients undergoing major liver resection and RFA for multifocal were matched with 128 patients undergoing major resection alone during the study period. There were no difference in terms of the baseline characteristics, comorbidities. Patients in both groups had similar Child Pugh grading and MELD score. In spite of the higher ICG retention rate at 15 minutes for the combined group, it was still within the normal range (12.7% vs. 10.6%, p = 0.026). Both groups of patients suffered from similar number of tumors, but only 47 patients (36.7%) were bilobar in the liver resection group. There were no difference in terms of the operative procedures, outcome and hospital stay, neither the pathology of the tumors. Despite the multifocality of the HCC and bilobar involvement, combined resection resulted in similar overall survival (5-year 24.1% vs. 40.1%, p = 0.164). Prolonged hospital stay and tumor with microvascular invasion were the risk factors for poorer overall survival. CONCLUSION: Aggressive management of HCC with combination modalities, such as liver resection and RFA, should always be considered for bilobar multifocal HCC.-
dc.languageeng-
dc.publisherS. Karger AG. The Journal's web site is located at http://content.karger.com/ProdukteDB/produkte.asp?Aktion=JournalHome&ProduktNr=255487-
dc.relation.ispartofLiver Cancer-
dc.rightsLiver Cancer. Copyright © S. Karger AG.-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleCombined major liver resection and radiofrequency ablation for multifocal hepatocellular carcinoma-
dc.typeConference_Paper-
dc.identifier.emailShe, WH: brianshe@hku.hk-
dc.identifier.emailCheung, TT: cheung68@hku.hk-
dc.identifier.emailChan, ACY: acchan@hku.hk-
dc.identifier.emailChok, KSH: chok6275@hku.hk-
dc.identifier.emailDai, WC: daiwc@hku.hk-
dc.identifier.emailChan, SC: chanlsc@hkucc.hku.hk-
dc.identifier.emailPoon, RTP: poontp@hku.hk-
dc.identifier.emailLo, CM: chungmlo@hkucc.hku.hk-
dc.identifier.authorityCheung, TT=rp02129-
dc.identifier.authorityChan, ACY=rp00310-
dc.identifier.authorityChok, KSH=rp02110-
dc.identifier.authorityChan, SC=rp01568-
dc.identifier.authorityPoon, RTP=rp00446-
dc.identifier.authorityLo, CM=rp00412-
dc.description.naturepostprint-
dc.identifier.doi10.1159/000443566-
dc.identifier.hkuros263850-
dc.identifier.volume5-
dc.identifier.issuesuppl. 1-
dc.identifier.spage50, abstract no. 0053-
dc.identifier.epage50, abstract no. 0053-
dc.publisher.placeSwitzerland-

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