File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
  • Find via Find It@HKUL
Supplementary

Conference Paper: Potential use of melatonin as a therapy for intracerebral haemorrhage

TitlePotential use of melatonin as a therapy for intracerebral haemorrhage
Authors
Issue Date2016
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/
Citation
The 21st Medical Research Conference (MRC 2016), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 16 January 2016. In Hong Kong Medical Journal, 2016, v. 22 suppl. 1, p. 34, abstract no. 49 How to Cite?
AbstractINTRODUCTION: Intracerebral haemorrhage (ICH) is a devastating form of stroke and is characterised by rupture of blood vessels within the brain parenchyma. Patients with ICH may suffer from severe neurological sequels like motor deficits and cognitive impairment. We aimed to study the neurological outcomes of ICH. The potential therapeutic effects of melatonin on ICH were also investigated. METHODS: ICH was induced in the rat by an intrastriatal injection of collagenase type IV. Haematoma size and neurological deficits were studied 24 hours later. To study the beneficial effect of melatonin on ICH, repetitive intraperitoneal injections of melatonin were given to the rats at 2, 24, and 48 hours after ICH; they were sacrificed at 72 hours. In addition, the neuroprotective role of melatonin was further investigated in vitro. RESULTS: At 24 hours after the ICH induction, haematoma was found in the brain parenchyma. The rats also manifested neurological deficits. Repetitive intraperitoneal injections of melatonin at 50 mg/kg achieved significant improvement in the rotarod test at 72 hours after ICH when compared to 24 hours. The expression of ED-1 (a marker of activated microglia) in the peri-hematomal tissue was decreased in 50 mg/kg melatonintreated group when compared to the vehicle-treated group. In the in-vitro study, the SH-SY5Y neuronal cells were challenged with red blood cell lysate, and the cell viability was reduced in a dose-dependent manner. Melatonin at optimal concentrations could increase the neuronal viability. CONCLUSION: Our present results reveal some potential neuroprotective effects of melatonin in a rat model of ICH and may provide a new insight to the future drug development for this devastating disease.
Persistent Identifierhttp://hdl.handle.net/10722/232499
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorLEUNG, JWH-
dc.contributor.authorCheung, RTF-
dc.date.accessioned2016-09-20T05:30:26Z-
dc.date.available2016-09-20T05:30:26Z-
dc.date.issued2016-
dc.identifier.citationThe 21st Medical Research Conference (MRC 2016), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 16 January 2016. In Hong Kong Medical Journal, 2016, v. 22 suppl. 1, p. 34, abstract no. 49-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/232499-
dc.description.abstractINTRODUCTION: Intracerebral haemorrhage (ICH) is a devastating form of stroke and is characterised by rupture of blood vessels within the brain parenchyma. Patients with ICH may suffer from severe neurological sequels like motor deficits and cognitive impairment. We aimed to study the neurological outcomes of ICH. The potential therapeutic effects of melatonin on ICH were also investigated. METHODS: ICH was induced in the rat by an intrastriatal injection of collagenase type IV. Haematoma size and neurological deficits were studied 24 hours later. To study the beneficial effect of melatonin on ICH, repetitive intraperitoneal injections of melatonin were given to the rats at 2, 24, and 48 hours after ICH; they were sacrificed at 72 hours. In addition, the neuroprotective role of melatonin was further investigated in vitro. RESULTS: At 24 hours after the ICH induction, haematoma was found in the brain parenchyma. The rats also manifested neurological deficits. Repetitive intraperitoneal injections of melatonin at 50 mg/kg achieved significant improvement in the rotarod test at 72 hours after ICH when compared to 24 hours. The expression of ED-1 (a marker of activated microglia) in the peri-hematomal tissue was decreased in 50 mg/kg melatonintreated group when compared to the vehicle-treated group. In the in-vitro study, the SH-SY5Y neuronal cells were challenged with red blood cell lysate, and the cell viability was reduced in a dose-dependent manner. Melatonin at optimal concentrations could increase the neuronal viability. CONCLUSION: Our present results reveal some potential neuroprotective effects of melatonin in a rat model of ICH and may provide a new insight to the future drug development for this devastating disease.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.titlePotential use of melatonin as a therapy for intracerebral haemorrhage-
dc.typeConference_Paper-
dc.identifier.emailCheung, RTF: rtcheung@hkucc.hku.hk-
dc.identifier.authorityCheung, RTF=rp00434-
dc.identifier.hkuros266708-
dc.identifier.volume22-
dc.identifier.issuesuppl. 1-
dc.identifier.spage34, abstract no. 49-
dc.identifier.epage34, abstract no. 49-
dc.publisher.placeHong Kong-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats