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Conference Paper: Inorganic mercury poisoning due to cosmetic cream in Hong Kong: a case series

TitleInorganic mercury poisoning due to cosmetic cream in Hong Kong: a case series
Authors
Issue Date2016
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/
Citation
The 21st Medical Research Conference (MRC 2016), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 16 June 2016. In Hong Kong Medical Journal, 2016, v. 22 suppl. 1, p. 50, abstract no. 82 How to Cite?
AbstractINTRODUCTION: Physicians might prescribe corticosteroid in addition to chelation therapy in patients with inorganic mercury poisoning with the presence of proteinuria. However, there is controversy over the efficacy of corticosteroid in treating these patients. Therefore, there is a need to study a case series to evaluate patient characteristics and treatment outcome of inorganic mercury poisoning due to cosmetic cream for skin whitening. METHODS: Cases in 2008 to 2015 were identified and reviewed using the electronic database of the Hong Kong Poison Information Centre. For inclusion, patients must have documented inorganic mercury toxicity, use of cosmetic cream, and proteinuria. Patients were classified into two groups (dimercaptosuccinic acid chelation or combination therapy of dimercaptosuccinic acid and prednisolone) according to their treatment received during period of mercury toxicity. The primary outcome of the study was the duration to proteinuria remission. Data were analysed using SPSS statistics version 22. RESULTS: Seventeen patients were included in this study: 15 (88.2%) patients were female and 13 (76.5%) patients were Southeast Asians. Of the patients, 14 (82.4%) were treated with chelation, prednisolone, or combination therapy. Comparing patients with combination therapy to chelation only, there was no significant difference in the duration to achieve proteinuria remission (67.3 ± 4.91 vs 46.8 ± 12.5 days; P=0.307). Baseline blood mercury level correlated with duration to achieve proteinuria remission (r=0.79; P=0.004). CONCLUSION: Inorganic mercury in certain skin-whitening creams can cause mercury poisoning and nephrotic syndrome. The duration of proteinuria is related to baseline blood mercury level and is not significantly affected by the addition of corticosteroid to chelation therapy.
Persistent Identifierhttp://hdl.handle.net/10722/232478
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorCheung, TT-
dc.contributor.authorTsoi, MF-
dc.contributor.authorCheung, BMY-
dc.date.accessioned2016-09-20T05:30:17Z-
dc.date.available2016-09-20T05:30:17Z-
dc.date.issued2016-
dc.identifier.citationThe 21st Medical Research Conference (MRC 2016), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 16 June 2016. In Hong Kong Medical Journal, 2016, v. 22 suppl. 1, p. 50, abstract no. 82-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/232478-
dc.description.abstractINTRODUCTION: Physicians might prescribe corticosteroid in addition to chelation therapy in patients with inorganic mercury poisoning with the presence of proteinuria. However, there is controversy over the efficacy of corticosteroid in treating these patients. Therefore, there is a need to study a case series to evaluate patient characteristics and treatment outcome of inorganic mercury poisoning due to cosmetic cream for skin whitening. METHODS: Cases in 2008 to 2015 were identified and reviewed using the electronic database of the Hong Kong Poison Information Centre. For inclusion, patients must have documented inorganic mercury toxicity, use of cosmetic cream, and proteinuria. Patients were classified into two groups (dimercaptosuccinic acid chelation or combination therapy of dimercaptosuccinic acid and prednisolone) according to their treatment received during period of mercury toxicity. The primary outcome of the study was the duration to proteinuria remission. Data were analysed using SPSS statistics version 22. RESULTS: Seventeen patients were included in this study: 15 (88.2%) patients were female and 13 (76.5%) patients were Southeast Asians. Of the patients, 14 (82.4%) were treated with chelation, prednisolone, or combination therapy. Comparing patients with combination therapy to chelation only, there was no significant difference in the duration to achieve proteinuria remission (67.3 ± 4.91 vs 46.8 ± 12.5 days; P=0.307). Baseline blood mercury level correlated with duration to achieve proteinuria remission (r=0.79; P=0.004). CONCLUSION: Inorganic mercury in certain skin-whitening creams can cause mercury poisoning and nephrotic syndrome. The duration of proteinuria is related to baseline blood mercury level and is not significantly affected by the addition of corticosteroid to chelation therapy.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.titleInorganic mercury poisoning due to cosmetic cream in Hong Kong: a case series-
dc.typeConference_Paper-
dc.identifier.emailCheung, TT: tcheungt@hku.hk-
dc.identifier.emailCheung, BMY: mycheung@hkucc.hku.hk-
dc.identifier.authorityCheung, TT=rp01682-
dc.identifier.authorityCheung, BMY=rp01321-
dc.identifier.hkuros265902-
dc.identifier.volume22-
dc.identifier.issuesuppl. 1-
dc.identifier.spage50, abstract no. 82-
dc.identifier.epage50, abstract no. 82-
dc.publisher.placeHong Kong-

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