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Conference Paper: Age difference in responses to cigarette smoke-induced injury in a rat model

TitleAge difference in responses to cigarette smoke-induced injury in a rat model
Authors
Issue Date2016
PublisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/
Citation
The 21st Medical Research Conference (MRC 2016), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 16 January 2016. In Hong Kong Medical Journal, 2016, v. 22 n. 1 suppl., p. 41, abstract no. 63 How to Cite?
AbstractINTRODUCTION: Cigarette smoking is the major cause of chronic obstructive pulmonary disease. Recent theories suggest that older individuals may be more prone to the effects of cigarette smoking. This study aimed at studying the effects of ageing on inflammatory responses using a rat model of passive smoking. METHODS: Male Sprague-Dawley rats of 4 months old (young) or 8 months old (grown-up adult) were exposed to air as control or cigarette smoke (CS; 4%) twice daily for 1 hour each for 7 consecutive days. Lung function was measured using whole-body plethysmograph (DSI) before the commencement of CS exposure and after the last exposure. On the day of sacrifice, bronchoalveolar lavage fluid (BALF) was collected, total cells were counted, and cytospins were prepared. Levels of CINC-1 and MCP-1 in BALF were measured using ELISA. RESULTS: Short-term CS exposure led to an increase in cell number in BALF (total, neutrophils and macrophages), accompanied by an increase in CINC-1 and MCP-1 levels compared to control treatment. There was a trend of a heightened response in the older group compared with the young group. In addition, there was a reduction in tidal volume in the older rats after 7 days of CS exposure, which was not found in the young rats. CONCLUSION: We conclude that the age of the animals could affect the inflammatory responses to short-term cigarette smoking.
Persistent Identifierhttp://hdl.handle.net/10722/232402
ISSN
2015 Impact Factor: 0.887
2015 SCImago Journal Rankings: 0.279

 

DC FieldValueLanguage
dc.contributor.authorLiu, WKK-
dc.contributor.authorCui, Y-
dc.contributor.authorLiang, Y-
dc.contributor.authorIp, MSM-
dc.contributor.authorMak, JCW-
dc.date.accessioned2016-09-20T05:29:44Z-
dc.date.available2016-09-20T05:29:44Z-
dc.date.issued2016-
dc.identifier.citationThe 21st Medical Research Conference (MRC 2016), Department of Medicine, The University of Hong Kong, Queen Mary Hospital, Hong Kong, 16 January 2016. In Hong Kong Medical Journal, 2016, v. 22 n. 1 suppl., p. 41, abstract no. 63-
dc.identifier.issn1024-2708-
dc.identifier.urihttp://hdl.handle.net/10722/232402-
dc.description.abstractINTRODUCTION: Cigarette smoking is the major cause of chronic obstructive pulmonary disease. Recent theories suggest that older individuals may be more prone to the effects of cigarette smoking. This study aimed at studying the effects of ageing on inflammatory responses using a rat model of passive smoking. METHODS: Male Sprague-Dawley rats of 4 months old (young) or 8 months old (grown-up adult) were exposed to air as control or cigarette smoke (CS; 4%) twice daily for 1 hour each for 7 consecutive days. Lung function was measured using whole-body plethysmograph (DSI) before the commencement of CS exposure and after the last exposure. On the day of sacrifice, bronchoalveolar lavage fluid (BALF) was collected, total cells were counted, and cytospins were prepared. Levels of CINC-1 and MCP-1 in BALF were measured using ELISA. RESULTS: Short-term CS exposure led to an increase in cell number in BALF (total, neutrophils and macrophages), accompanied by an increase in CINC-1 and MCP-1 levels compared to control treatment. There was a trend of a heightened response in the older group compared with the young group. In addition, there was a reduction in tidal volume in the older rats after 7 days of CS exposure, which was not found in the young rats. CONCLUSION: We conclude that the age of the animals could affect the inflammatory responses to short-term cigarette smoking.-
dc.languageeng-
dc.publisherHong Kong Academy of Medicine Press. The Journal's web site is located at http://www.hkmj.org/-
dc.relation.ispartofHong Kong Medical Journal-
dc.rightsHong Kong Medical Journal. Copyright © Hong Kong Academy of Medicine Press.-
dc.titleAge difference in responses to cigarette smoke-induced injury in a rat model-
dc.typeConference_Paper-
dc.identifier.emailLiu, WKK: kwkliu@hku.hk-
dc.identifier.emailLiang, Y: winniell@hku.hk-
dc.identifier.emailIp, MSM: msmip@hku.hk-
dc.identifier.emailMak, JCW: judithmak@hku.hk-
dc.identifier.authorityIp, MSM=rp00347-
dc.identifier.authorityMak, JCW=rp00352-
dc.identifier.hkuros264106-
dc.identifier.volume22-
dc.identifier.issue1 suppl.-
dc.identifier.spage41, abstract no. 63-
dc.identifier.epage41, abstract no. 63-
dc.publisher.placeHong Kong-

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