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Conference Paper: Improvement of biventricular myocardial function in patients with cirrhosis following liver transplantation

TitleImprovement of biventricular myocardial function in patients with cirrhosis following liver transplantation
Authors
Issue Date2015
PublisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/
Citation
The 2015 Annual Congress of the European Society of Cardiology (ESC), London, UK., 29 August-2 September 2015. In European Heart Journal, 2015, v. 36 suppl. 1, p. 1108 How to Cite?
AbstractBACKGROUND: Patients with cirrhosis have been shown to be associated with myocardial dysfunction. However, limited studies have evaluated cardiac function in patients with cirrhosis before and after liver transplantation. PURPOSE: The aim of the study is to evaluate biventricular myocardial function before and after liver transplantation in patients with cirrhosis. METHODS: A total of 67 consecutive patients (mean age 54.9±7.7 years; 73.1% male) with cirrhosis referred for liver transplantation were recruited. Conventional and advanced 2-dimensional speckle tracking echocardiography were performed to assess for biventricular function. During the follow up period, a total of 41 patients underwent successful liver transplantation and the rest remains on the liver transplantation waiting list. A second echocardiography was performed in all patients within the following date (patients following liver transplantation: 18.2±6.6 months and patients who did not receive liver transplantation: 20.4±8.3 months). RESULTS: For patients who received liver transplantation, a reduction of left ventricular (LV) diastolic and systolic volume (71.3±16.9ml vs. 91.4±27.1ml and 25.2±7.7ml vs. 32.2±12.9ml, respectively; both P<0.01), a trend towards a lower LV mass (195.8±54.5g vs. 214.0±55.1g, P=0.05) and improved LV global longitudinal and circumferential strains (−20.8±2.0% vs. −18.5±2.6% and −18.7±2.3% vs. −16.5±2.4%, respectively; both P<0.01) were observed. In addition, these patients showed a reduction of right ventricular (RV) end diastolic and systolic area (12.4±2.2cm2 vs. 13.6±3.7cm2 and 5.5±1.2cm2 vs. 6.2±2.1cm2, respectively; both P<0.05), and improved RV strain (−23.2±2.5% vs. −21.0±4.8%, P<0.01) following liver transplantation. For patients who did not receive liver transplantation, both left and right heart dimension and function remained similar between first and second echocardiography. CONCLUSION: The present study demonstrates that patients with cirrhosis had reduced biventricular chamber dimension and improved biventricular systolic function following liver transplantation. No such association was found in patients who did not receive liver transplantation. The present finding thus suggested that myocardial dysfunction in patients with cirrhosis could be reversed following successful liver transplantation.
DescriptionPoster Session 7 - Echo-imaging evaluation of the right ventricle: no. P6303
This journal suppl. entitled: ESC Congress 2015, London, United Kingdom, 29 August-2 September 2015
Persistent Identifierhttp://hdl.handle.net/10722/232395
ISSN
2015 Impact Factor: 15.064
2015 SCImago Journal Rankings: 6.997

 

DC FieldValueLanguage
dc.contributor.authorChen, Y-
dc.contributor.authorZhen, Z-
dc.contributor.authorLiu, JH-
dc.contributor.authorTse, HF-
dc.contributor.authorYiu, KH-
dc.date.accessioned2016-09-20T05:29:41Z-
dc.date.available2016-09-20T05:29:41Z-
dc.date.issued2015-
dc.identifier.citationThe 2015 Annual Congress of the European Society of Cardiology (ESC), London, UK., 29 August-2 September 2015. In European Heart Journal, 2015, v. 36 suppl. 1, p. 1108-
dc.identifier.issn0195-668X-
dc.identifier.urihttp://hdl.handle.net/10722/232395-
dc.descriptionPoster Session 7 - Echo-imaging evaluation of the right ventricle: no. P6303-
dc.descriptionThis journal suppl. entitled: ESC Congress 2015, London, United Kingdom, 29 August-2 September 2015-
dc.description.abstractBACKGROUND: Patients with cirrhosis have been shown to be associated with myocardial dysfunction. However, limited studies have evaluated cardiac function in patients with cirrhosis before and after liver transplantation. PURPOSE: The aim of the study is to evaluate biventricular myocardial function before and after liver transplantation in patients with cirrhosis. METHODS: A total of 67 consecutive patients (mean age 54.9±7.7 years; 73.1% male) with cirrhosis referred for liver transplantation were recruited. Conventional and advanced 2-dimensional speckle tracking echocardiography were performed to assess for biventricular function. During the follow up period, a total of 41 patients underwent successful liver transplantation and the rest remains on the liver transplantation waiting list. A second echocardiography was performed in all patients within the following date (patients following liver transplantation: 18.2±6.6 months and patients who did not receive liver transplantation: 20.4±8.3 months). RESULTS: For patients who received liver transplantation, a reduction of left ventricular (LV) diastolic and systolic volume (71.3±16.9ml vs. 91.4±27.1ml and 25.2±7.7ml vs. 32.2±12.9ml, respectively; both P<0.01), a trend towards a lower LV mass (195.8±54.5g vs. 214.0±55.1g, P=0.05) and improved LV global longitudinal and circumferential strains (−20.8±2.0% vs. −18.5±2.6% and −18.7±2.3% vs. −16.5±2.4%, respectively; both P<0.01) were observed. In addition, these patients showed a reduction of right ventricular (RV) end diastolic and systolic area (12.4±2.2cm2 vs. 13.6±3.7cm2 and 5.5±1.2cm2 vs. 6.2±2.1cm2, respectively; both P<0.05), and improved RV strain (−23.2±2.5% vs. −21.0±4.8%, P<0.01) following liver transplantation. For patients who did not receive liver transplantation, both left and right heart dimension and function remained similar between first and second echocardiography. CONCLUSION: The present study demonstrates that patients with cirrhosis had reduced biventricular chamber dimension and improved biventricular systolic function following liver transplantation. No such association was found in patients who did not receive liver transplantation. The present finding thus suggested that myocardial dysfunction in patients with cirrhosis could be reversed following successful liver transplantation.-
dc.languageeng-
dc.publisherOxford University Press. The Journal's web site is located at http://eurheartj.oxfordjournals.org/-
dc.relation.ispartofEuropean Heart Journal-
dc.rightsPre-print: Journal Title] ©: [year] [owner as specified on the article] Published by Oxford University Press [on behalf of xxxxxx]. All rights reserved. Pre-print (Once an article is published, preprint notice should be amended to): This is an electronic version of an article published in [include the complete citation information for the final version of the Article as published in the print edition of the Journal.] Post-print: This is a pre-copy-editing, author-produced PDF of an article accepted for publication in [insert journal title] following peer review. The definitive publisher-authenticated version [insert complete citation information here] is available online at: xxxxxxx [insert URL that the author will receive upon publication here].-
dc.titleImprovement of biventricular myocardial function in patients with cirrhosis following liver transplantation-
dc.typeConference_Paper-
dc.identifier.emailLiu, JH: liujuhua@hku.hk-
dc.identifier.emailTse, HF: hftse@hkucc.hku.hk-
dc.identifier.emailYiu, KH: khkyiu@hku.hk-
dc.identifier.authorityTse, HF=rp00428-
dc.identifier.authorityYiu, KH=rp01490-
dc.identifier.doi10.1093/eurheartj/ehv401-
dc.identifier.hkuros263232-
dc.identifier.volume36-
dc.identifier.issuesuppl. 1-
dc.identifier.spage1108-
dc.identifier.epage1108-
dc.publisher.placeUnited Kingdom-

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