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Conference Paper: Modulatory effects of orexin on the functional maturation of central vestibular system in motor coordination and spatial recognition

TitleModulatory effects of orexin on the functional maturation of central vestibular system in motor coordination and spatial recognition
Authors
Issue Date2016
PublisherThe University of Hong Kong.
Citation
The 2016 Neuroscience Symposium and Annual Scientific Conference of the Hong Kong Society of Neurosciences, The University of Hong Kong, Hong Kong, 18 May 2016. In Programme Book, 2016, p. 39, abstract no. P20 How to Cite?
AbstractOrexin is a hypothalamic neuropeptide that is known to be involved in animals’ balance and motor coordination. To test whether neonatal perturbation of orexinergic synapses in the vestibular nucleus (VN) exerts any effect on the maturation of vestibular-related behaviors, we blocked/activated orexin receptors in the VN of postnatal day (P) 1 rats by implanting polymer (Elvax) slices loaded with orexin receptor antagonist (SB334867) or agonist ([Ala11, D-Leu 15]-orexin-B) onto the dorsal surface of VN for slow release of the drug to the underlying VN. Specific behavioral tests including negative geotaxis (a graviceptive response), surface righting (ability to correct body orientation to erect position) and air righting were performed on these rats at different stages of postnatal development until adulthood. Neonatal treatment with antagonist accelerated acquisition of negative geotaxis and surface righting from P7 to P6, as well as air righting from P21 to P16. In contrast, neonatal treatment with agonist delayed acquisition of negative geotaxis by 4 days and surface righting by 1 day. These findings reveal the unique role of orexin on functional maturation of the vestibular system. Moreover, neonatal treatment of the VN with agonist impaired the performance of both motor coordination (as revealed by rotarod test and balanced beam test) and spatial navigation (as indicated by dead reckoning/ path integration) at the adult stage. On the contrary, antagonist treatment enhanced the performance in spatial navigation. These findings suggest that neonatal modulation of orexinergic transmission in the neonatal VN perturbs the maturation of spatial recognition. [Supported by NSFC/RGC N_HKU 735/14]
DescriptionConference Theme: Nature and Nurture in Brain Functions
Persistent Identifierhttp://hdl.handle.net/10722/231499

 

DC FieldValueLanguage
dc.contributor.authorLam, UTF-
dc.contributor.authorChan, YS-
dc.date.accessioned2016-09-20T05:23:33Z-
dc.date.available2016-09-20T05:23:33Z-
dc.date.issued2016-
dc.identifier.citationThe 2016 Neuroscience Symposium and Annual Scientific Conference of the Hong Kong Society of Neurosciences, The University of Hong Kong, Hong Kong, 18 May 2016. In Programme Book, 2016, p. 39, abstract no. P20-
dc.identifier.urihttp://hdl.handle.net/10722/231499-
dc.descriptionConference Theme: Nature and Nurture in Brain Functions-
dc.description.abstractOrexin is a hypothalamic neuropeptide that is known to be involved in animals’ balance and motor coordination. To test whether neonatal perturbation of orexinergic synapses in the vestibular nucleus (VN) exerts any effect on the maturation of vestibular-related behaviors, we blocked/activated orexin receptors in the VN of postnatal day (P) 1 rats by implanting polymer (Elvax) slices loaded with orexin receptor antagonist (SB334867) or agonist ([Ala11, D-Leu 15]-orexin-B) onto the dorsal surface of VN for slow release of the drug to the underlying VN. Specific behavioral tests including negative geotaxis (a graviceptive response), surface righting (ability to correct body orientation to erect position) and air righting were performed on these rats at different stages of postnatal development until adulthood. Neonatal treatment with antagonist accelerated acquisition of negative geotaxis and surface righting from P7 to P6, as well as air righting from P21 to P16. In contrast, neonatal treatment with agonist delayed acquisition of negative geotaxis by 4 days and surface righting by 1 day. These findings reveal the unique role of orexin on functional maturation of the vestibular system. Moreover, neonatal treatment of the VN with agonist impaired the performance of both motor coordination (as revealed by rotarod test and balanced beam test) and spatial navigation (as indicated by dead reckoning/ path integration) at the adult stage. On the contrary, antagonist treatment enhanced the performance in spatial navigation. These findings suggest that neonatal modulation of orexinergic transmission in the neonatal VN perturbs the maturation of spatial recognition. [Supported by NSFC/RGC N_HKU 735/14]-
dc.languageeng-
dc.publisherThe University of Hong Kong.-
dc.relation.ispartofNeuroscience Symposium & Annual Scientific Conference of the Hong Kong Society of Neurosciences-
dc.titleModulatory effects of orexin on the functional maturation of central vestibular system in motor coordination and spatial recognition-
dc.typeConference_Paper-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.authorityChan, YS=rp00318-
dc.identifier.hkuros266239-
dc.identifier.spage39, abstract no. P20-
dc.identifier.epage39, abstract no. P20-
dc.publisher.placeHong Kong-

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