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Conference Paper: Chondroitin sulphate-derived disaccharides: a potential drug for axons regrowing across the glial scar

TitleChondroitin sulphate-derived disaccharides: a potential drug for axons regrowing across the glial scar
Authors
Issue Date2016
PublisherThe University of Hong Kong.
Citation
The 2016 Neuroscience Symposium and Annual Scientific Conference of the Hong Kong Society of Neurosciences, The University of Hong Kong, Hong Kong, 18 May 2016. In Programme Book, 2016, p. 51, abstract no. P42 How to Cite?
AbstractChondroitin sulphate (CS) moieties enriched in the glial scar can be cleaved by chondroitinase ABC (ChABC) delivered to the site, resulting in improved outcomes in axonal regrowth and functional recovery. We postulate that the disaccharide products generated during digestion play parts in the enhancement of axonal growth. With a co-culture model of astrocytes and cortical neurons, treated with recombinant ChABC (rChABC) combinations, washed of digestion products and then treated with selected CS disaccharides, neurite growth-promoting effects of CS disaccharides were revealed. By contrast, control treatments with sucrose or CS tetrasaccharides did not promote neurite growth. Among the different CS disaccharides, DdiUA-2S was found superior in the enhancement of neurite growth. Without the pre-treatment of rChABC, the growth-promoting effect was less pronounced and the differences among the CS disaccharides with regard to growthpromoting effects were insignificant. Evidence is thus provided for (1) the role of ChABC activities, in disrupting the barrier to axonal growth, and (2) possible supplementation with the neurite growth-promoting CS disaccharides means to overcome the axonal growth barrier at the glial scar.
DescriptionConference Theme: Nature and Nurture in Brain Functions
Persistent Identifierhttp://hdl.handle.net/10722/231469

 

DC FieldValueLanguage
dc.contributor.authorTam, KW-
dc.contributor.authorChan, YS-
dc.contributor.authorShum, DKY-
dc.date.accessioned2016-09-20T05:23:21Z-
dc.date.available2016-09-20T05:23:21Z-
dc.date.issued2016-
dc.identifier.citationThe 2016 Neuroscience Symposium and Annual Scientific Conference of the Hong Kong Society of Neurosciences, The University of Hong Kong, Hong Kong, 18 May 2016. In Programme Book, 2016, p. 51, abstract no. P42-
dc.identifier.urihttp://hdl.handle.net/10722/231469-
dc.descriptionConference Theme: Nature and Nurture in Brain Functions-
dc.description.abstractChondroitin sulphate (CS) moieties enriched in the glial scar can be cleaved by chondroitinase ABC (ChABC) delivered to the site, resulting in improved outcomes in axonal regrowth and functional recovery. We postulate that the disaccharide products generated during digestion play parts in the enhancement of axonal growth. With a co-culture model of astrocytes and cortical neurons, treated with recombinant ChABC (rChABC) combinations, washed of digestion products and then treated with selected CS disaccharides, neurite growth-promoting effects of CS disaccharides were revealed. By contrast, control treatments with sucrose or CS tetrasaccharides did not promote neurite growth. Among the different CS disaccharides, DdiUA-2S was found superior in the enhancement of neurite growth. Without the pre-treatment of rChABC, the growth-promoting effect was less pronounced and the differences among the CS disaccharides with regard to growthpromoting effects were insignificant. Evidence is thus provided for (1) the role of ChABC activities, in disrupting the barrier to axonal growth, and (2) possible supplementation with the neurite growth-promoting CS disaccharides means to overcome the axonal growth barrier at the glial scar.-
dc.languageeng-
dc.publisherThe University of Hong Kong.-
dc.relation.ispartofNeuroscience Symposium & Annual Scientific Conference of the Hong Kong Society of Neurosciences-
dc.titleChondroitin sulphate-derived disaccharides: a potential drug for axons regrowing across the glial scar-
dc.typeConference_Paper-
dc.identifier.emailTam, KW: tamkw@hku.hk-
dc.identifier.emailChan, YS: yschan@hku.hk-
dc.identifier.emailShum, DKY: shumdkhk@hkucc.hku.hk-
dc.identifier.authorityChan, YS=rp00318-
dc.identifier.authorityShum, DKY=rp00321-
dc.identifier.hkuros263581-
dc.identifier.spage51, abstract no. P42-
dc.identifier.epage51, abstract no. P42-
dc.publisher.placeHong Kong-

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