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Article: Well-defined poly(lactic acid)s containing poly(ethylene glycol) side chains

TitleWell-defined poly(lactic acid)s containing poly(ethylene glycol) side chains
Authors
Issue Date2012
PublisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/macromolecules
Citation
Macromolecules, 2012, v. 45 n. 1, p. 62-69 How to Cite?
AbstractPoly(ethylene glycol) (PEG) side-chain functionalized lactide analogues have been synthesized in four steps from commercially available l-lactide. The key step in the synthesis is the 1,3-dipolar cycloaddition between PEG-azides and a highly strained spirolactide-heptene monomer, which proceeds in high conversions. The PEG-grafted lactide analogues were polymerized via ring-opening polymerization using triazabicyclodecene as organocatalyst to give well-defined tri- and hepta(ethylene glycol)-poly(lactide)s (PLA) with molecular weights above 10 kDa and polydispersity indices between 1.6 and 2.1. PEG-poly(lactide) (PLA) with PEG chain M n 2000 was also prepared, but GPC analysis showed a bimodal profile indicating the presence of starting macromonomer. Cell adhesion assays were performed using MC3T3-E1 osteoblast-like cells demonstrating that PEG-containing PLA reduces cell adhesion significantly when compared to unfunctionalized PLA.
Persistent Identifierhttp://hdl.handle.net/10722/231078
ISSN
2015 Impact Factor: 5.554
2015 SCImago Journal Rankings: 2.497

 

DC FieldValueLanguage
dc.contributor.authorCastillo, JA-
dc.contributor.authorBorchmann, DE-
dc.contributor.authorCheng, AY-
dc.contributor.authorWang, Y-
dc.contributor.authorHu, C-
dc.contributor.authorGarcía, AJ-
dc.contributor.authorWeck, M-
dc.date.accessioned2016-09-02T02:18:19Z-
dc.date.available2016-09-02T02:18:19Z-
dc.date.issued2012-
dc.identifier.citationMacromolecules, 2012, v. 45 n. 1, p. 62-69-
dc.identifier.issn0024-9297-
dc.identifier.urihttp://hdl.handle.net/10722/231078-
dc.description.abstractPoly(ethylene glycol) (PEG) side-chain functionalized lactide analogues have been synthesized in four steps from commercially available l-lactide. The key step in the synthesis is the 1,3-dipolar cycloaddition between PEG-azides and a highly strained spirolactide-heptene monomer, which proceeds in high conversions. The PEG-grafted lactide analogues were polymerized via ring-opening polymerization using triazabicyclodecene as organocatalyst to give well-defined tri- and hepta(ethylene glycol)-poly(lactide)s (PLA) with molecular weights above 10 kDa and polydispersity indices between 1.6 and 2.1. PEG-poly(lactide) (PLA) with PEG chain M n 2000 was also prepared, but GPC analysis showed a bimodal profile indicating the presence of starting macromonomer. Cell adhesion assays were performed using MC3T3-E1 osteoblast-like cells demonstrating that PEG-containing PLA reduces cell adhesion significantly when compared to unfunctionalized PLA.-
dc.languageeng-
dc.publisherAmerican Chemical Society. The Journal's web site is located at http://pubs.acs.org/macromolecules-
dc.relation.ispartofMacromolecules-
dc.titleWell-defined poly(lactic acid)s containing poly(ethylene glycol) side chains-
dc.typeArticle-
dc.identifier.emailWang, Y: wanglab@hku.hk-
dc.identifier.authorityWang, Y=rp02191-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/ma2016387-
dc.identifier.scopuseid_2-s2.0-84862927512-
dc.identifier.volume45-
dc.identifier.issue1-
dc.identifier.spage62-
dc.identifier.epage69-
dc.publisher.placeUnited States-

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