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Article: Impact of nodal ratio on survival in recurrent nasopharyngeal carcinoma

TitleImpact of nodal ratio on survival in recurrent nasopharyngeal carcinoma
Authors
KeywordsRecurrent nasopharyngeal carcinoma
Nodal recurrence
Nodal ratio
Survival
Neck recurrence
Issue Date2015
Citation
Head and Neck, 2015, v. 37, n. 1, p. 12-17 How to Cite?
Abstract© 2014 Wiley Periodicals, Inc.Background. The purpose of this study was to investigate if nodal ratio has a prognostic role in the survival of patients with recurrent nasopharyngeal carcinoma (NPC) in the neck. Methods. Patients with recurrent NPC in the neck who were treated in Queen Mary Hospital from 2000 to 2011 were identified. Clinical data, pathological results, and survival outcome were analyzed. Results. Only nodal ratio remained as a statistically significant predictor in multivariate analysis for nodal recurrence (p5.045) and nodal recurrence-free survival (p5.010). All other predictors lost significance when compared with each other and with nodal ratio. Nodal ratio was also a significant predictor for overall survival (OS) in univariate analysis (p5.001) but lost its significance in multivariate analysis. The cutoff points 10% and 15% effectively stratified the patients into 3 risk groups (p5.02). Conclusion. In patients with NPC with neck recurrence, nodal ratio (the ratio of positive nodes to the total number of nodes examined) is a strong predictor of further nodal recurrence and nodal recurrence-free survival. Nodal ratio also impacts the OS but loses its significance in multivariate analysis, including concurrent local recurrence. Stratification of patients into low, medium, and high-risk groups according to nodal ratio may have a potential role in guiding therapeutic decision-making. Therefore, further exploration in this area is warranted.
Persistent Identifierhttp://hdl.handle.net/10722/230971
ISSN
2015 Impact Factor: 2.76
2015 SCImago Journal Rankings: 1.233

 

DC FieldValueLanguage
dc.contributor.authorChan, Richie Chiu Lung-
dc.contributor.authorChan, Jimmy Yu Wai-
dc.date.accessioned2016-09-01T06:07:17Z-
dc.date.available2016-09-01T06:07:17Z-
dc.date.issued2015-
dc.identifier.citationHead and Neck, 2015, v. 37, n. 1, p. 12-17-
dc.identifier.issn1043-3074-
dc.identifier.urihttp://hdl.handle.net/10722/230971-
dc.description.abstract© 2014 Wiley Periodicals, Inc.Background. The purpose of this study was to investigate if nodal ratio has a prognostic role in the survival of patients with recurrent nasopharyngeal carcinoma (NPC) in the neck. Methods. Patients with recurrent NPC in the neck who were treated in Queen Mary Hospital from 2000 to 2011 were identified. Clinical data, pathological results, and survival outcome were analyzed. Results. Only nodal ratio remained as a statistically significant predictor in multivariate analysis for nodal recurrence (p5.045) and nodal recurrence-free survival (p5.010). All other predictors lost significance when compared with each other and with nodal ratio. Nodal ratio was also a significant predictor for overall survival (OS) in univariate analysis (p5.001) but lost its significance in multivariate analysis. The cutoff points 10% and 15% effectively stratified the patients into 3 risk groups (p5.02). Conclusion. In patients with NPC with neck recurrence, nodal ratio (the ratio of positive nodes to the total number of nodes examined) is a strong predictor of further nodal recurrence and nodal recurrence-free survival. Nodal ratio also impacts the OS but loses its significance in multivariate analysis, including concurrent local recurrence. Stratification of patients into low, medium, and high-risk groups according to nodal ratio may have a potential role in guiding therapeutic decision-making. Therefore, further exploration in this area is warranted.-
dc.languageeng-
dc.relation.ispartofHead and Neck-
dc.subjectRecurrent nasopharyngeal carcinoma-
dc.subjectNodal recurrence-
dc.subjectNodal ratio-
dc.subjectSurvival-
dc.subjectNeck recurrence-
dc.titleImpact of nodal ratio on survival in recurrent nasopharyngeal carcinoma-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1002/hed.23544-
dc.identifier.pmid24307492-
dc.identifier.scopuseid_2-s2.0-84918819874-
dc.identifier.volume37-
dc.identifier.issue1-
dc.identifier.spage12-
dc.identifier.epage17-
dc.identifier.eissn1097-0347-

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