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- Publisher Website: 10.1002/hed.23344
- Scopus: eid_2-s2.0-84898798555
- PMID: 23595941
- WOS: WOS:000334423500007
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Article: Accuracy of intraoperative frozen section analysis of nasopharyngeal carcinoma resection margins
Title | Accuracy of intraoperative frozen section analysis of nasopharyngeal carcinoma resection margins |
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Authors | |
Keywords | margins frozen sections FSA nasopharyngeal carcinoma NPC |
Issue Date | 2014 |
Citation | Head and Neck, 2014, v. 36, n. 5, p. 638-642 How to Cite? |
Abstract | Background Frozen section analysis (FSA) is frequently used in salvage surgery for recurrent or residual nasopharyngeal carcinoma (rNPC) after radiotherapy to ensure adequate tumor removal. However, the diagnostic accuracy of FSA in rNPC has never been clearly established. We believe that this is the first study to specifically address these issues. Methods Patients with rNPC who underwent nasopharyngectomy in Queen Mary Hospital from 2006 to 2011 were identified. Clinical data, FSA results, and permanent histological results were analyzed. Results In the tissue-based analysis, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were 70.6%, 100%, 100%, 95.2%, and 95.7%, respectively. Only 37% of inconclusive FSA turned out negative on permanent histology. Presence of inconclusive (p = .000) or positive (p = .000) FSA results in the same operation significantly lowered the NPV of FSA. Conclusion FSA is useful in ensuring clear resection margins for rNPC. Further resection is advisable in cases of inconclusive FSA results. Copyright © 2013 Wiley Periodicals, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/230954 |
ISSN | 2023 Impact Factor: 2.3 2023 SCImago Journal Rankings: 1.034 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Chan, Richie C L | - |
dc.contributor.author | Ho, Siu Lun | - |
dc.contributor.author | Chan, Jimmy Y. | - |
dc.date.accessioned | 2016-09-01T06:07:14Z | - |
dc.date.available | 2016-09-01T06:07:14Z | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | Head and Neck, 2014, v. 36, n. 5, p. 638-642 | - |
dc.identifier.issn | 1043-3074 | - |
dc.identifier.uri | http://hdl.handle.net/10722/230954 | - |
dc.description.abstract | Background Frozen section analysis (FSA) is frequently used in salvage surgery for recurrent or residual nasopharyngeal carcinoma (rNPC) after radiotherapy to ensure adequate tumor removal. However, the diagnostic accuracy of FSA in rNPC has never been clearly established. We believe that this is the first study to specifically address these issues. Methods Patients with rNPC who underwent nasopharyngectomy in Queen Mary Hospital from 2006 to 2011 were identified. Clinical data, FSA results, and permanent histological results were analyzed. Results In the tissue-based analysis, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracy were 70.6%, 100%, 100%, 95.2%, and 95.7%, respectively. Only 37% of inconclusive FSA turned out negative on permanent histology. Presence of inconclusive (p = .000) or positive (p = .000) FSA results in the same operation significantly lowered the NPV of FSA. Conclusion FSA is useful in ensuring clear resection margins for rNPC. Further resection is advisable in cases of inconclusive FSA results. Copyright © 2013 Wiley Periodicals, Inc. | - |
dc.language | eng | - |
dc.relation.ispartof | Head and Neck | - |
dc.subject | margins | - |
dc.subject | frozen sections | - |
dc.subject | FSA | - |
dc.subject | nasopharyngeal carcinoma | - |
dc.subject | NPC | - |
dc.title | Accuracy of intraoperative frozen section analysis of nasopharyngeal carcinoma resection margins | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1002/hed.23344 | - |
dc.identifier.pmid | 23595941 | - |
dc.identifier.scopus | eid_2-s2.0-84898798555 | - |
dc.identifier.hkuros | 215014 | - |
dc.identifier.volume | 36 | - |
dc.identifier.issue | 5 | - |
dc.identifier.spage | 638 | - |
dc.identifier.epage | 642 | - |
dc.identifier.eissn | 1097-0347 | - |
dc.identifier.isi | WOS:000334423500007 | - |
dc.identifier.issnl | 1043-3074 | - |