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Article: Lack of short-term adjunctive effect of systemic neridronate in non-surgical periodontal therapy of advanced generalized chronic periodontitis: An open label-randomized clinical trial

TitleLack of short-term adjunctive effect of systemic neridronate in non-surgical periodontal therapy of advanced generalized chronic periodontitis: An open label-randomized clinical trial
Authors
KeywordsChronic periodontitis
Non-surgical periodontal therapy
Bisphosphonates
Issue Date2009
Citation
Journal of Clinical Periodontology, 2009, v. 36, n. 5, p. 419-427 How to Cite?
AbstractGraziani F, Cei S, Guerrero A, La Ferla F, Vano M, Tonetti M, Gabriele M. Lack of short-term adjunctive effect of systemic neridronate in non-surgical periodontal therapy of advanced generalized chronic periodontitis: an open label randomized clinical trial. J Clin Periodontol 2009; 36: 419-427. doi: 10.1111j.1600-051X.2009.01388.x. Abstract Aim: To determine if the adjunctive use of intra-muscular neridronate (NE) during non-surgical periodontal treatment (PT) provides, in patients with generalized chronic periodontitis (GCP), adjunctive benefits as compared with PT alone 3 months after the completion of a 3-month NE therapy. Material and Methods: Sixty GCP healthy patients were randomly assigned to control (CG) or test group (TG). CG patients received PT only. Thirty subjects in TG also received adjunctive NE (12.5 mg in an i.m. injectionweek for 3 months). Clinical parameters were evaluated at baseline, at the end of NE treatment (3 months after PT) and 3 months after the completion of NE treatment (6 months after the beginning of PT). Results: Groups were balanced at baseline and all clinical parameters showed improvement between baseline and follow-ups. At 6 months improvements from baseline at sites with deep pocket depth (≥7 mm) were 3.2 mm [95% confidence interval (CI): 2.7-3.9] in CG and 3.0 mm (95% CI: 2.3-3.8) in TG with a non-significant difference of 0.2 mm (95% CI: -1.0-0.5; ancova; p=0.549) between groups. Secondary outcomes did not show significant differences between groups. No major adverse events were reported. Conclusions: The adjunctive use of NE during PT did not result in additional short-term improvements in periodontal conditions of GCP patients when compared with PT. © 2009 John Wiley & Sons AS.
Persistent Identifierhttp://hdl.handle.net/10722/230833
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848

 

DC FieldValueLanguage
dc.contributor.authorGraziani, Filippo-
dc.contributor.authorCei, Silvia-
dc.contributor.authorGuerrero, Adrian-
dc.contributor.authorLa Ferla, Fabio-
dc.contributor.authorVano, Michele-
dc.contributor.authorTonetti, Maurizio-
dc.contributor.authorGabriele, Mario-
dc.date.accessioned2016-09-01T06:06:55Z-
dc.date.available2016-09-01T06:06:55Z-
dc.date.issued2009-
dc.identifier.citationJournal of Clinical Periodontology, 2009, v. 36, n. 5, p. 419-427-
dc.identifier.issn0303-6979-
dc.identifier.urihttp://hdl.handle.net/10722/230833-
dc.description.abstractGraziani F, Cei S, Guerrero A, La Ferla F, Vano M, Tonetti M, Gabriele M. Lack of short-term adjunctive effect of systemic neridronate in non-surgical periodontal therapy of advanced generalized chronic periodontitis: an open label randomized clinical trial. J Clin Periodontol 2009; 36: 419-427. doi: 10.1111j.1600-051X.2009.01388.x. Abstract Aim: To determine if the adjunctive use of intra-muscular neridronate (NE) during non-surgical periodontal treatment (PT) provides, in patients with generalized chronic periodontitis (GCP), adjunctive benefits as compared with PT alone 3 months after the completion of a 3-month NE therapy. Material and Methods: Sixty GCP healthy patients were randomly assigned to control (CG) or test group (TG). CG patients received PT only. Thirty subjects in TG also received adjunctive NE (12.5 mg in an i.m. injectionweek for 3 months). Clinical parameters were evaluated at baseline, at the end of NE treatment (3 months after PT) and 3 months after the completion of NE treatment (6 months after the beginning of PT). Results: Groups were balanced at baseline and all clinical parameters showed improvement between baseline and follow-ups. At 6 months improvements from baseline at sites with deep pocket depth (≥7 mm) were 3.2 mm [95% confidence interval (CI): 2.7-3.9] in CG and 3.0 mm (95% CI: 2.3-3.8) in TG with a non-significant difference of 0.2 mm (95% CI: -1.0-0.5; ancova; p=0.549) between groups. Secondary outcomes did not show significant differences between groups. No major adverse events were reported. Conclusions: The adjunctive use of NE during PT did not result in additional short-term improvements in periodontal conditions of GCP patients when compared with PT. © 2009 John Wiley & Sons AS.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.subjectChronic periodontitis-
dc.subjectNon-surgical periodontal therapy-
dc.subjectBisphosphonates-
dc.titleLack of short-term adjunctive effect of systemic neridronate in non-surgical periodontal therapy of advanced generalized chronic periodontitis: An open label-randomized clinical trial-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-051X.2009.01388.x-
dc.identifier.pmid19419443-
dc.identifier.scopuseid_2-s2.0-64949139040-
dc.identifier.volume36-
dc.identifier.issue5-
dc.identifier.spage419-
dc.identifier.epage427-
dc.identifier.eissn1600-051X-

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