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Article: Vitamin D receptor polymorphism (-1056 Taq-I) interacts with smoking for the presence and progression of periodontitis

TitleVitamin D receptor polymorphism (-1056 Taq-I) interacts with smoking for the presence and progression of periodontitis
Authors
KeywordsSmoking
Vitamin D receptor
Periodontitis
Genetic polymorphisms
Progression
Issue Date2008
Citation
Journal of Clinical Periodontology, 2008, v. 35, n. 7, p. 561-567 How to Cite?
AbstractAim: The aim of this analysis was to investigate the relationship between a vitamin D receptor (VDR) polymorphism and the diagnosis and progression of periodontitis. Material and Methods: Data were derived from two different studies, including 231 subjects with healthy periodontium, 224 aggressive periodontitis and 79 chronic periodontitis (CP) patients in a case-control investigation. Sixty-one of these CP patients also took part in an observational study with a 1-year follow-up, in which progression of periodontitis was determined at the subject level. All 534 subjects provided a blood sample from which genomic DNA was extracted to study VDR -1056 TaqI polymorphism. Results: The interaction between smoking and VDR polymorphism was associated with the diagnosis of periodontitis in Caucasians [p=0.001, odds ratio (OR)=1.33, 95% confidence intervals (CI)=1.12-1.57] and all subjects (p=0.033, OR=1.60, 95% CI=1.04-2.48). In the longitudinal study, subjects were divided into two clusters at 1 year according to the median number of progressing sites (Δcumulative attachment loss >2 mm). Logistic regression analysis revealed that the interaction between VDR Taq-I polymorphism and smoking showed limited evidence of association with the "severe progression" cluster (p=0.033, OR=15.24, 95% CI=1.24-187.42). Conclusions: Vitamin D receptor Taq-I TT polymorphism was moderately associated with both the presence and the progression of periodontitis in smokers, while no association was detected in non-smoking individuals. VDR genetic factors may interact with smoking in the pathogenesis of periodontitis. © 2008 Blackwell Munksgaard.
Persistent Identifierhttp://hdl.handle.net/10722/230812
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848

 

DC FieldValueLanguage
dc.contributor.authorNibali, Luigi-
dc.contributor.authorParkar, Mohamed-
dc.contributor.authorD'Aiuto, Francesco-
dc.contributor.authorSuvan, Jean E.-
dc.contributor.authorBrett, Peter M.-
dc.contributor.authorGriffiths, Gareth S.-
dc.contributor.authorRosin, Michael-
dc.contributor.authorSchwahn, Christian-
dc.contributor.authorTonetti, Maurizio S.-
dc.date.accessioned2016-09-01T06:06:52Z-
dc.date.available2016-09-01T06:06:52Z-
dc.date.issued2008-
dc.identifier.citationJournal of Clinical Periodontology, 2008, v. 35, n. 7, p. 561-567-
dc.identifier.issn0303-6979-
dc.identifier.urihttp://hdl.handle.net/10722/230812-
dc.description.abstractAim: The aim of this analysis was to investigate the relationship between a vitamin D receptor (VDR) polymorphism and the diagnosis and progression of periodontitis. Material and Methods: Data were derived from two different studies, including 231 subjects with healthy periodontium, 224 aggressive periodontitis and 79 chronic periodontitis (CP) patients in a case-control investigation. Sixty-one of these CP patients also took part in an observational study with a 1-year follow-up, in which progression of periodontitis was determined at the subject level. All 534 subjects provided a blood sample from which genomic DNA was extracted to study VDR -1056 TaqI polymorphism. Results: The interaction between smoking and VDR polymorphism was associated with the diagnosis of periodontitis in Caucasians [p=0.001, odds ratio (OR)=1.33, 95% confidence intervals (CI)=1.12-1.57] and all subjects (p=0.033, OR=1.60, 95% CI=1.04-2.48). In the longitudinal study, subjects were divided into two clusters at 1 year according to the median number of progressing sites (Δcumulative attachment loss >2 mm). Logistic regression analysis revealed that the interaction between VDR Taq-I polymorphism and smoking showed limited evidence of association with the "severe progression" cluster (p=0.033, OR=15.24, 95% CI=1.24-187.42). Conclusions: Vitamin D receptor Taq-I TT polymorphism was moderately associated with both the presence and the progression of periodontitis in smokers, while no association was detected in non-smoking individuals. VDR genetic factors may interact with smoking in the pathogenesis of periodontitis. © 2008 Blackwell Munksgaard.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.subjectSmoking-
dc.subjectVitamin D receptor-
dc.subjectPeriodontitis-
dc.subjectGenetic polymorphisms-
dc.subjectProgression-
dc.titleVitamin D receptor polymorphism (-1056 Taq-I) interacts with smoking for the presence and progression of periodontitis-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-051X.2008.01233.x-
dc.identifier.pmid18410395-
dc.identifier.scopuseid_2-s2.0-44849101887-
dc.identifier.volume35-
dc.identifier.issue7-
dc.identifier.spage561-
dc.identifier.epage567-
dc.identifier.eissn1600-051X-

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