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Article: A randomized-controlled trial of low-dose doxycycline for periodontitis in smokers

TitleA randomized-controlled trial of low-dose doxycycline for periodontitis in smokers
Authors
KeywordsDental scaling
Tetracydine
Periodontal diseases
Randomized-controlled trial
Smoking
Issue Date2007
Citation
Journal of Clinical Periodontology, 2007, v. 34, n. 4, p. 325-333 How to Cite?
AbstractBackground/Aim: Tobacco use reduces the effect of non-surgical periodontal therapy. Host-modulation with low-dose doxycycline (LDD) might favour repair and promote an improved treatment response. The aim of this study was to investigate the effect of LDD in smokers on non-surgical periodontal therapy. Material and Methods: This was a parallel arm, randomized, identical placebocontrolled trial with masking of examiner, care-giver, participant and statistician and 6 months of follow-up. Patients received non-surgical therapy and 3 months of test or control drug. Statistical analysis used both conventional methods and multilevel modelling. Results: Eighteen control and 16 test patients completed the study. The velocity of change was statistically greater for the test group for clinical attachment level - 0.19 mm/month (95% CI = - 0.34, 0.04; p = 0.012) and probing depth 0.30mm/ month (95% CI = -0.42, - 0.17; p<0.001). However, no differences were observed for absolute change in clinical or biochemical markers at 6 months. Conclusions: This study does not provide evidence of a benefit of using LDD as an adjunct to non-surgical periodontal therapy in smokers. © 2007 Blackwell Munksgaard.
Persistent Identifierhttp://hdl.handle.net/10722/230777
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848

 

DC FieldValueLanguage
dc.contributor.authorNeedleman, Ian-
dc.contributor.authorSuvan, Jean-
dc.contributor.authorGilthorpe, Mark S.-
dc.contributor.authorTucker, Richard-
dc.contributor.authorSt George, Geoff-
dc.contributor.authorGiannobile, William-
dc.contributor.authorTonetti, Maurizio-
dc.contributor.authorJarvis, Martin-
dc.date.accessioned2016-09-01T06:06:46Z-
dc.date.available2016-09-01T06:06:46Z-
dc.date.issued2007-
dc.identifier.citationJournal of Clinical Periodontology, 2007, v. 34, n. 4, p. 325-333-
dc.identifier.issn0303-6979-
dc.identifier.urihttp://hdl.handle.net/10722/230777-
dc.description.abstractBackground/Aim: Tobacco use reduces the effect of non-surgical periodontal therapy. Host-modulation with low-dose doxycycline (LDD) might favour repair and promote an improved treatment response. The aim of this study was to investigate the effect of LDD in smokers on non-surgical periodontal therapy. Material and Methods: This was a parallel arm, randomized, identical placebocontrolled trial with masking of examiner, care-giver, participant and statistician and 6 months of follow-up. Patients received non-surgical therapy and 3 months of test or control drug. Statistical analysis used both conventional methods and multilevel modelling. Results: Eighteen control and 16 test patients completed the study. The velocity of change was statistically greater for the test group for clinical attachment level - 0.19 mm/month (95% CI = - 0.34, 0.04; p = 0.012) and probing depth 0.30mm/ month (95% CI = -0.42, - 0.17; p<0.001). However, no differences were observed for absolute change in clinical or biochemical markers at 6 months. Conclusions: This study does not provide evidence of a benefit of using LDD as an adjunct to non-surgical periodontal therapy in smokers. © 2007 Blackwell Munksgaard.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.subjectDental scaling-
dc.subjectTetracydine-
dc.subjectPeriodontal diseases-
dc.subjectRandomized-controlled trial-
dc.subjectSmoking-
dc.titleA randomized-controlled trial of low-dose doxycycline for periodontitis in smokers-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-051X.2007.01058.x-
dc.identifier.pmid17324155-
dc.identifier.scopuseid_2-s2.0-33947329976-
dc.identifier.volume34-
dc.identifier.issue4-
dc.identifier.spage325-
dc.identifier.epage333-
dc.identifier.eissn1600-051X-

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