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Article: Periodontitis and systemic inflammation: Control of the local infection is associated with a reduction in serum inflammatory markers

TitlePeriodontitis and systemic inflammation: Control of the local infection is associated with a reduction in serum inflammatory markers
Authors
KeywordsInfection
Inflammation
Periodontitis
Atherosclerosis
C-reactive protein
Issue Date2004
Citation
Journal of Dental Research, 2004, v. 83, n. 2, p. 156-160 How to Cite?
AbstractSevere periodontitis is associated with elevated inflammatory markers in otherwise healthy populations. However, the nature of this association has not been determined. Our aim was to assess whether the degree of response to periodontal therapy was associated with changes in serological markers of systemic inflammation. Ninety-four systemically healthy subjects with severe generalized periodontitis participated in a prospective six-month blind intervention trial. Periodontal parameters and inflammatory markers [C-reactive Protein (CRP) and Interleukin-6 (IL-6)] were evaluated prior to and 2 and 6 mos after delivery of standard non-surgical periodontal therapy. Six months after treatment, significant reductions in serum IL-6 (p < 0.001, median decrease 0.2 ng/L, 95% CI 0.1-0.4 ng/L) and CRP (p < 0.0001, median decrease 0.5 mg/L, 95% CI 0.4-0.7) were observed. Decreases in inflammatory markers were significant in subjects with above average clinical response to periodontal therapy after correction for possible confounders. Periodontitis may add to the systemic inflammatory burden of affected individuals.
Persistent Identifierhttp://hdl.handle.net/10722/230756
ISSN
2015 Impact Factor: 4.602
2015 SCImago Journal Rankings: 1.714

 

DC FieldValueLanguage
dc.contributor.authorD'Aiuto, F.-
dc.contributor.authorParkar, M.-
dc.contributor.authorAndreou, G.-
dc.contributor.authorSuvan, J.-
dc.contributor.authorBrett, P. M.-
dc.contributor.authorReady, D.-
dc.contributor.authorTonetti, M. S.-
dc.date.accessioned2016-09-01T06:06:43Z-
dc.date.available2016-09-01T06:06:43Z-
dc.date.issued2004-
dc.identifier.citationJournal of Dental Research, 2004, v. 83, n. 2, p. 156-160-
dc.identifier.issn0022-0345-
dc.identifier.urihttp://hdl.handle.net/10722/230756-
dc.description.abstractSevere periodontitis is associated with elevated inflammatory markers in otherwise healthy populations. However, the nature of this association has not been determined. Our aim was to assess whether the degree of response to periodontal therapy was associated with changes in serological markers of systemic inflammation. Ninety-four systemically healthy subjects with severe generalized periodontitis participated in a prospective six-month blind intervention trial. Periodontal parameters and inflammatory markers [C-reactive Protein (CRP) and Interleukin-6 (IL-6)] were evaluated prior to and 2 and 6 mos after delivery of standard non-surgical periodontal therapy. Six months after treatment, significant reductions in serum IL-6 (p < 0.001, median decrease 0.2 ng/L, 95% CI 0.1-0.4 ng/L) and CRP (p < 0.0001, median decrease 0.5 mg/L, 95% CI 0.4-0.7) were observed. Decreases in inflammatory markers were significant in subjects with above average clinical response to periodontal therapy after correction for possible confounders. Periodontitis may add to the systemic inflammatory burden of affected individuals.-
dc.languageeng-
dc.relation.ispartofJournal of Dental Research-
dc.subjectInfection-
dc.subjectInflammation-
dc.subjectPeriodontitis-
dc.subjectAtherosclerosis-
dc.subjectC-reactive protein-
dc.titlePeriodontitis and systemic inflammation: Control of the local infection is associated with a reduction in serum inflammatory markers-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.pmid14742655-
dc.identifier.scopuseid_2-s2.0-3242773959-
dc.identifier.volume83-
dc.identifier.issue2-
dc.identifier.spage156-
dc.identifier.epage160-

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