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Article: Periodontal therapy: A novel acute inflammatory model

TitlePeriodontal therapy: A novel acute inflammatory model
Authors
KeywordsC-reactive protein
Periodontal therapy
Inflammatory model
Cytokines
Periodontal disease
Issue Date2005
Citation
Inflammation Research, 2005, v. 54, n. 10, p. 412-414 How to Cite?
AbstractObjective and Design: We designed a clinical trial at the Eastman Dental Hospital with the objective of developing a novel in vivo inflammatory model. Subjects: We recruited 55 subjects suffering from severe periodontitis. Treatment: Participants received intensive periodontal therapy. Methods: Blood samples were collected at baseline and 1 and 7 and 30 days after treatment and processed for a series of biomarkers (TNF-alpha, IL-6, CRP and Fibrinogen) by high-sensitivity assays and differential blood counts (standard laboratory procedures). Results: TNF-alpha levels were significantly raised only after 1 day of therapy (P < 0.01) whereas IL-6 (P < 0.01), CRP (P < 0.001) and Fibrinogen (P < 0.001) concentrations peaked 24hrs after and returned to baseline values within one month following therapy. Mild neutrophilia, monocytosis and lymphopenia were also observed. Conclusions: Intensive periodontal therapy induces a one week moderate inflammatory response and therefore it is proposed as a novel therapeutic and reliable non drug-induced in vivo model of acute inflammation.
Persistent Identifierhttp://hdl.handle.net/10722/230749
ISSN
2015 Impact Factor: 2.557
2015 SCImago Journal Rankings: 0.934

 

DC FieldValueLanguage
dc.contributor.authorD'Aiuto, F.-
dc.contributor.authorParkar, M.-
dc.contributor.authorTonetti, M. S.-
dc.date.accessioned2016-09-01T06:06:42Z-
dc.date.available2016-09-01T06:06:42Z-
dc.date.issued2005-
dc.identifier.citationInflammation Research, 2005, v. 54, n. 10, p. 412-414-
dc.identifier.issn1023-3830-
dc.identifier.urihttp://hdl.handle.net/10722/230749-
dc.description.abstractObjective and Design: We designed a clinical trial at the Eastman Dental Hospital with the objective of developing a novel in vivo inflammatory model. Subjects: We recruited 55 subjects suffering from severe periodontitis. Treatment: Participants received intensive periodontal therapy. Methods: Blood samples were collected at baseline and 1 and 7 and 30 days after treatment and processed for a series of biomarkers (TNF-alpha, IL-6, CRP and Fibrinogen) by high-sensitivity assays and differential blood counts (standard laboratory procedures). Results: TNF-alpha levels were significantly raised only after 1 day of therapy (P < 0.01) whereas IL-6 (P < 0.01), CRP (P < 0.001) and Fibrinogen (P < 0.001) concentrations peaked 24hrs after and returned to baseline values within one month following therapy. Mild neutrophilia, monocytosis and lymphopenia were also observed. Conclusions: Intensive periodontal therapy induces a one week moderate inflammatory response and therefore it is proposed as a novel therapeutic and reliable non drug-induced in vivo model of acute inflammation.-
dc.languageeng-
dc.relation.ispartofInflammation Research-
dc.subjectC-reactive protein-
dc.subjectPeriodontal therapy-
dc.subjectInflammatory model-
dc.subjectCytokines-
dc.subjectPeriodontal disease-
dc.titlePeriodontal therapy: A novel acute inflammatory model-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s00011-005-1375-4-
dc.identifier.pmid16283108-
dc.identifier.scopuseid_2-s2.0-27744451008-
dc.identifier.volume54-
dc.identifier.issue10-
dc.identifier.spage412-
dc.identifier.epage414-
dc.identifier.eissn1420-908X-

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