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Article: Periodontal wound healing following GTR therapy of dehiscence-type defects in the monkey: Short-, medium- and long-term healing

TitlePeriodontal wound healing following GTR therapy of dehiscence-type defects in the monkey: Short-, medium- and long-term healing
Authors
KeywordsMonkeys
Periodontal re-generation
Artificial membranes
Dehiscence defects
Issue Date2005
Citation
Journal of Clinical Periodontology, 2005, v. 32, n. 8, p. 905-914 How to Cite?
AbstractObjective: To describe periodontal wound healing in dehiscence-type defects following guided tissue re-generation (GTR) therapy. Methods: Ten adult Macaca fascicularis monkeys were used. Buccal dehiscence-type defects were created at the maxillary second pre-molars and second molars. After 3 months, GTR surgery was performed. The animals were euthanized at 6 weeks, 6 months and 2 years after surgery. Block biopsies were harvested, and prepared for histological analysis. Results: A new attachment apparatus was structured already after 6 weeks of healing. A 10-20 μm thin layer of acellular extrinsic fibre cementum (AEFC) had formed along the instrumented root surface. At 6 months, the thickness of the supracrestal cementum was comparable with that at 6 weeks, while the thickness of the subcrestal cementum had increased to 40-60 μm. In this zone, the cementum consisted of an inner layer of AEFC attached to the circum-pulpal dentin and an outer layer of cellular mixed fibre cementum (CMFC). The numerical extrinsic fibre density was twice that at 6 weeks. At 2 years, the periodontal tissues resembled the pristine periodontium. Conclusion: Periodontal healing following GTR therapy of recession-type defects will result in a restitutio ad integrum, i.e. healing by re-generation. A continuous maturation process occurs over at least 2 years. © Blackwell Munksgaard, 2005.
Persistent Identifierhttp://hdl.handle.net/10722/230743
ISSN
2015 Impact Factor: 3.915
2015 SCImago Journal Rankings: 1.848

 

DC FieldValueLanguage
dc.contributor.authorGraziani, Filippo-
dc.contributor.authorLaurell, Lars-
dc.contributor.authorTonetti, Maurizio-
dc.contributor.authorGottlow, Jan-
dc.contributor.authorBerglundh, Tord-
dc.date.accessioned2016-09-01T06:06:41Z-
dc.date.available2016-09-01T06:06:41Z-
dc.date.issued2005-
dc.identifier.citationJournal of Clinical Periodontology, 2005, v. 32, n. 8, p. 905-914-
dc.identifier.issn0303-6979-
dc.identifier.urihttp://hdl.handle.net/10722/230743-
dc.description.abstractObjective: To describe periodontal wound healing in dehiscence-type defects following guided tissue re-generation (GTR) therapy. Methods: Ten adult Macaca fascicularis monkeys were used. Buccal dehiscence-type defects were created at the maxillary second pre-molars and second molars. After 3 months, GTR surgery was performed. The animals were euthanized at 6 weeks, 6 months and 2 years after surgery. Block biopsies were harvested, and prepared for histological analysis. Results: A new attachment apparatus was structured already after 6 weeks of healing. A 10-20 μm thin layer of acellular extrinsic fibre cementum (AEFC) had formed along the instrumented root surface. At 6 months, the thickness of the supracrestal cementum was comparable with that at 6 weeks, while the thickness of the subcrestal cementum had increased to 40-60 μm. In this zone, the cementum consisted of an inner layer of AEFC attached to the circum-pulpal dentin and an outer layer of cellular mixed fibre cementum (CMFC). The numerical extrinsic fibre density was twice that at 6 weeks. At 2 years, the periodontal tissues resembled the pristine periodontium. Conclusion: Periodontal healing following GTR therapy of recession-type defects will result in a restitutio ad integrum, i.e. healing by re-generation. A continuous maturation process occurs over at least 2 years. © Blackwell Munksgaard, 2005.-
dc.languageeng-
dc.relation.ispartofJournal of Clinical Periodontology-
dc.subjectMonkeys-
dc.subjectPeriodontal re-generation-
dc.subjectArtificial membranes-
dc.subjectDehiscence defects-
dc.titlePeriodontal wound healing following GTR therapy of dehiscence-type defects in the monkey: Short-, medium- and long-term healing-
dc.typeArticle-
dc.description.natureLink_to_subscribed_fulltext-
dc.identifier.doi10.1111/j.1600-051X.2005.00789.x-
dc.identifier.pmid15998277-
dc.identifier.scopuseid_2-s2.0-22444442458-
dc.identifier.volume32-
dc.identifier.issue8-
dc.identifier.spage905-
dc.identifier.epage914-

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